??????? (fMRI) ???????

1
??????????
???????? ???
2

• ??????? (fMRI) ???????
• ???????
• fMRI?? ?????(DWI)
• ????(PI)
• ?????????????
• ???????(BOLD)????PI
• ???????(MRS)

3

• ???????(BOLD) ???fMRI?????,????????????????,??????
  ???????????
• ?????BOLD????1992???????(Kwong,
  Ogawa)?????(Bandettini)????
• ???????????????????,????????????????????????????

4
BOLD????
???(??????) ???? ???(????????????)
??????????????????????? ?????????????,?T2??????
?(2-3)
5
BOLD????

• ?????????
• ??????(EPI)
• SE-EPI(????,?????)
• GRE-EPI(??????)
• ??????

6
BOLD????

• BOLD???????????35mm,????????????,?PET?
• BOLD?????????,???EEG?,??????????,????-????????????
  ??????????

7
?????

• BOLD??????????(??????????????????4??,????????????
  ??1)
• ?????(???????????????)??????,????????????
• ?????????????????????????????

8
????(?0.3Hz) ????(?0.9Hz)
???????????(4.0T, TR200ms, TE26ms) ????????,????
??????
9

• ??????????
• Navigator(??) echo correction methods
• Non-navigator (???)echo correction methods

10
BOLD?????

• ????????
• ?????(???????????????????)
• ????
• ???
• ???????
• ??????

11
?????

• ????(Blocked design)
• ??,???????,?????????,???1.????????????????????
  ??????????,2.????????????,?????????????
• ??????(Event-related design)
• ?????????????,???????????,??????????????????

12
????
??????
13
BOLD????

• ????
• ????
• ?????????
• ???????????
• ??Talairach???????

14
BOLD????

• ???????
• ????(??????t??)
• ???????AFNI?Stimulate?SPM
• ????????????????

15
BOLD??????????

• BOLD ????????????
• ??(?????????)???
• (????????)???????
• ??????

16
BOLD??????????

• BOLD?????????????,??
• ?????????????????????
• ?? ???????????????????
• ?????????????????????
• ???????Wada??(????????)?
• ????????????????????

17
A
B
7????????????? A???????(V4)
B???????(MT) ????????P
18
??V4
??MT
19

• ????????????????????????????????????,??????????
  ??????????????????V4,?????????MT?????????MT,?V
  4??????????????????????????????,??????fMRI???????

20
???????????fMRI
21
(No Transcript)
22
???????????????
????
????
fMRI?????????????
23
???????????????
????
????
fMRI?????????????
24
Postcentral G. activation during
electroacupuncture
S1
S2
S1
S2
????fMRI
25

• ????????????(???1)??????(???6)
• gt??????,lt??????
• ??SPM????,??P??0.0001
• ?????????????,????????,????

26
????????
?????????
27
????????
?????????
28
????????fMRI
29

• Patient YGJ
• Male
• Age 52 years
• Right-handed
• Native Chinese speaker
• Education 9 years

30
T2WI at onset
31
Stimuli Chinese Numerals ???
Chinese Characters High
Frequency??? Low
Frequency??? Presented visually Press a button
if recognized
32
N H L H L N

Time 16 32 32 32 32 32
32 32 32 32 32 32 32
400s Image 1

200
N Chinese Numerals H High Frequency Words L
Low Frequency Words
33
Activation during reading Chinese characters
YJG, 1st Scan, 45 days after stroke
????????,???20,?????????,?(?)????,?Broca??Wernick
e????
Healthy Subject
????,???100,?????????,Broca ??Wernicke????
34
YJG, 2nd scan, 4 months after stroke
????????,???70,?????????, ?(?)?????,?Broca??Werni
cke?????
Healthy Subject
????,???100,?????????,Broca ??Wernicke????
35
Hemodynamic response in right and left (lesions)
extrastriate areas. Note that response in the
left extrastriate is about 16 seconds later than
that in the contralateral homologous area (right).
Left Extrastriate Area Right
Extrastriate Area
?????????????,?????????
36
Activation Volume and Center of Activation in the
exstrastriate areas in the patient and control
37

• ??????????????,????
• ?????????
• Broca??Wernicke??????????(???)????
• ???????????????????
• ???????????????????
• ????????,??????????
• ????????

38
YJG, M/52 ??????????
??????????????,????????????? Broca??Wernicke?????
?????(???)????
39

• ???????????????????????,?????????????????????

40

• ??????????????????????????????????????????????????
  ????

41

• ???(MR)?????????????????????(functional
  MRI)?MRI?????

42
??????????????

• ????????(diffusion MRI)
• ???????(perfusion MRI)
• ???????(MRI spectroscopy,MRs)
• ????????????(blood oxygen level dependent, BOLD)

43
DTI????????,??????????,????????????????
44
MRS??MR???????????????????,???????????????
???????PRESS??????
45
????????????