Karin Johansson

1
Infrastructures use, requirements prospect
inICT for health domain

• Karin Johansson
• ICT for Health
• DG Information Society Media
• European Commission

2
Outline

• ICT for Health research activities
• Relevant Grid-related activities
• Where are we going in the short/medium term?
• Where do we go beyond FP7?

3
WHO ARE WE? ICT for Health (eHealth) Unit,
European Commission Information Society and
Media DG

• eHealth unit
• established in 1989
• supported to date gt 450 projects worth gt 1
  Billion
• currently funds eHealth projects ( 100
  Million/year)
• The vision (since 1994) eHealth-enabled
  citizen-centred care or equivalently
  eHealth-enabled continuity of care
• Todays focus
• RD
• Personal Health Systems
• Patient Safety
• Modelling and Simulation of Human Physiology and
  Disease (Virtual Physiological Human)
• Support to deployment eHealth Action plan, Large
  Scale Pilots, Lead market initiative,
  Recommendation on Interoperability of EHRs,
  Communication on Telemedicine (2009)

4
Budget for research supported by the ICT for
Health unit in FP7

• Overall 340 M over 4 years (2007-2010)
• Personalisation of Healthcare
• Personal Health Systems (PHS)
• 72 M in 2007 - 63 M in 2009
• Patient safety (PS) - avoiding medical errors
• 30 M in 2007 - 30 M in 2009
• Predictive Medicine Virtual Physiological Human
  (VPH)
• Modelling/simulation of human physiology and
  disease
• 72 M in 2007 - 5 M in 2009 - 63 M in 2010
• Next work programme will cover 2011-2012 and
  will be published on CORDIS in Oct-Nov 2010.

5
Outline

• ICT for Health research activities
• Relevant Grid-related activities
• Where are we going in the short/medium term?
• Where do we go beyond FP7?

6
Where are Grid activities most relevant?

• VPH
• Need for data capacity originates from biomedical
  informatics roots
• Huge demand on
• Data storage/management
• Computing power
• Patient Safety (PS)
• Early detection of public health events
• Re-use of EHR data for research purposes

7
The Virtual Physiological Human (VPH) concept
Based on the ideas of the International Physiome
project
The Virtual Physiological Human is a
methodological and technological framework that
once established will enable the investigation of
the human body as a single complex system. One
of the 12 pioneer projects in FP6, The VPH
research roadmap developed by project STEP in
2007 www.europhysiome.org
- Personalised (patient-specific) healthcare
solutions - Early diagnostics predictive
medicine - Understanding diseases for the first
time across several biological levels
8
Virtual Physiological Human a schematic picture
Application
Computational resources
Knowledge of biological and physiological pathway
s, processes etc
Datamanagement
Clinical validation
Health care professionals Hospital
Data access Data processing

• Patient
• Specific Data
• -omics
• imaging
• clinical
• pharma

Patient
Prediction, Early Diagnosis, Treatment
9
First VPH Call FP7 call 2

• Technical focus
• Patient-specific computational modelling and
  simulation of organs targeting specific clinical
  needs.
• Data integration and new knowledge extraction.
• Clinical focus
• Simulation environments for surgery training,
  planning and intervention.
• Prediction of disease or early diagnosis.
• Simulation and assessment of the efficacy and
  safety of specific drugs.

10
Results of the 1st VPH call 15 FP7 projects
                  
Industry
Parallel VPH projects
Grid access CA
Liver surgery STREP
CV/ Atheroschlerosis IP
Breast cancer/ diagnosis STREP
Heart/ LVD surgery STREP
Osteoporosis IP
Oral cancer/ BM DT STREP
Cancer STREP
Networking NoE
Heart /CV disease STREP
Vascular/ AVF haemodialysis STREP
Liver cancer/RFA therapy STREP
Alzheimer's/ BM diagnosis STREP
Heart /CV disease STREP
Clinics
Reproduction from VPH NoE
Security and Privacy in VPH CA
11
Results of the 1st VPH call 15 FP7 projects
                  
Industry
Parallel VPH projects
Grid access CA
Liver surgery STREP
CV/ Atheroschlerosis IP
Breast cancer/ diagnosis STREP
Heart/ LVD surgery STREP
Osteoporosis IP
Oral cancer/ BM DT STREP
Cancer STREP
Networking NoE
Heart /CV disease STREP
Vascular/ AVF haemodialysis STREP
Liver cancer/RFA therapy STREP
Alzheimer's/ BM diagnosis STREP
Heart /CV disease STREP
Clinics
Reproduction from VPH NoE
Security and Privacy in VPH CA
12
Second VPH call FP7 call 4International
Cooperation on VPH

• Focus
• Interoperability (interfaces databases, web
  services, mark-up languages, meta-data,
  ontologies)
• Tools and services for global cooperation (for
  modelling/simulation, curated models,
  interconnected libraries)
• International validation environment (joint
  verification of clinical relevance of models)
• Budget 5M
• Results 5 proposals selected, all of which
  include international partners.

13
ICT for Patient safety

• Focus of Call
• ICT for safer surgery
• ICT for integration of clinical research and
  clinical care
• ICT-enabled early detection of public health
  events
• Budget 30M
• Results 9 retained (2 IPs, 6 STREPs, 1 SA)
• But Public health policy is mainly the
  responsibility of Directorate General Health and
  Consumer (DG SANCO) projects

14
eInfrastructure the European HPC Service
PRACE
National
DEISA and EGI
National/Regional
Local

DEISA/PRACE Symposium Amsterdam, NL
14
15
DEISA virtual HPC services

• 12 sites in 7 countries connected at 10 Gb/s
• Over 22,000 CPUs with an aggregated peak
  performance of close to 1 Peta flops
• Running larger parallel applications in
  individual sites
• Enabling workflow applications with grid
  technologies (UNICORE)
• Providing a global data management service
• Extreme Computing Initiative

DEISA/PRACE Symposium Amsterdam, NL
15
16
establishing new organisational model
for sustainable grid service provisioning
EGI_DS (Design study)
NGI- Nordic States
NGI-UK
NGI-IRL

• Key elements of new scheme
• Coordination/pooling of National and European
  funding for sustainable service provision and for
  more efficient planning of investments
• Service provisioning beyond project cycles
• One-stop-shop service provisioning (including
  training) to users who want to access grid-based
  resources

NGI-NL
NGI-PO
NGI-B
NGI-D
NGI-CZ
NGI-F
NGI-SK
NGI-A
NGI-E
NGI-I
NGI-P
NGI-GR
17
PRACE preparatory phase

• Late 2009 1PF in the top 5
• Late 2010 2 PF in the top 5 1PF in the top 10
• 2011 3 PF in the top 5 2 PF in the top 10
• 2020 an exaflop in the top 5

DEISA/PRACE Symposium Amsterdam, NL
17
18
Outline

• ICT for Health research activities
• Relevant Grid-related activities
• Where are we going in the short/medium term?
• Where do we go beyond FP7?

19
Virtual Physiological Humanfuture activities

• Keep the overall VPH goals
• Early diagnostics Predictive medicine
• Personalised (Patient-specific) healthcare
  solution
• By means of
• Modelling simulation of human physiology and
  disease-related processes
• Add emphasis on tools/infrastructure for
  biomedical researchers
• VPH in 2010
• Call 6 expected to open November 2009 and to
  close in April 2010
• Budget 63M

20
VPH infrastructureneeds

• Demand for
• Data management
• Computing power
• Requirements (coupling research activities with
  applications)
• No longer sufficient to make technological
  advances within the GRID research
• Engage users
• Usability/user accessibility
• Routinely used in applied research in other
  domains (VPH and others)
• Develop culture of sharing

21
VPH Call 6

• Focus a)
• Patient-specific computer based models and
  simulation
• Multiscale models simulation of organs/systems
  targeting specific clinical needs.
• Better understanding of the functioning of the
  organs and their pathologies aiming at
  prediction/early diagnosis.
• Emphasis on
• Integration of existing models
• Clinical benefits demonstrated
• Data acquisition, medical, clinical, bio research
  (if needed) lt 25
• Access to external computing facilities supported

22
VPH call 6

• Focus b)
• ICT tools, services and infrastructures for
  bio-medical researchers to support at least 2 of
  the 3 activities
• Share data and knowledge
• Jointly develop and share models/simulators
• Create collaborative environments
• Interface to access to resources like Grid/HPC
  infrastructures
• Ability to interface with existing medical
  research infrastructure
• Complement/compatible with existing
  methods/standards to be suggested by VPH-NoE

23
VPH Call 6

• Focus c) d)
• Evaluation and assessment of VPH Projects w.r.t.
  optimal use and contribution of
• Shared tools/infrastructure
• Clinical achievements
• Market potential/ penetration
• Observatory on achievements and evolution of the
  broader BMI field (e.g. bioinformatics, Medical
  informatics, neuro-informatics)
• Facilitate communication between projects
• Dissemination and training
• Aim at
• Sustaining cross collaboration among different
  fields
• Build on related NoEs.

24
Outline

• ICT for Health research activities
• Relevant Grid-related activities
• Where are we going in the short/medium term?
• Where do we go beyond FP7?

25
Support projects cutting across research,
innovation and deployment

• As part of COM(2009)116 on  A strategy for ICT
  RD Innovation in Europe , the Commission
  proposed
• Limited set of project cases that cut across the
  innovation chain
• Each project focused on specific characteristics
  of a pan-European service infrastructures
  addressing a specific societal goal
• To speed up the achievement of results there is
  a need to orchestrate efforts across research,
  innovation and deployment
• e.g. multi-financed large-scale initiatives in FP
  and CIP and national and regional actions
  including procurement of RD and innovation

26
Example projects cutting across research,
innovation and deployment

• European Large Scale Action in ICT for Health
• ICT service infrastructure for personal
  healthcare
• Specific societal goal better integrated care
  and management of chronic diseases at the point
  of need continuous and personalised care
• Specific characteristics accuracy of
  measurements, remote control by health
  professionals, self-monitoring

27
Contact persons

• DG Information Society and MediaUnit ICT for
  Health
• http//ec.europa.eu/information_society/ehealth
• Virtual Physiological Human team
• Joël Bacquet (joel.bacquet_at_ec.europa.eu)
• Karin Johansson (karin.johansson1_at_ec.europa.eu)
• Amalia Vlad (amalia-irina.vlad_at_ec.europa.eu)
• eInfrastructure team
• Enric Mitjana (enric.mitjana_at_ec.europa.eu)
• Maria Ramalho (maria.ramalho_at_ec.europa.eu)
• Bernhard Fabianek (bernhard.fabianek_at_ec.europa.eu
  )Contact person for EGI-related part of
  FP7-INFRASTRUCTURES-2010-2
• Monika Kacik (monika.kacik_at_ec.europa.eu)