Title: Pediatric Procedural Sedation Jana Stockwell, MD, FAAP Children
1Pediatric Procedural SedationJana
Stockwell, MD, FAAPChildrens Sedation
ServicesChildrens Healthcare of AtlantaEmory
University School of Medicine
2Why Not Sedate?
- Im gonna be so fast they wont even feel it.
- Theyre just crying because theyre being held
down. - Children dont feel pain
- Children dont remember pain
3Why Sedate?
- Efficacy
- Satisfaction
- Quality of study
- Do unto others
- Same injury, adults sedated more
4Goals
- Guard safety welfare of child
- Minimize physical discomfort pain
- Control anxiety, maximize potential for amnesia
- Control behavior movement to complete procedure
- Return patient to state safe for discharge
5CHOA _at_ Egleston Program
- CCM ED physicians
- Dedicated radiology H/O sedation nurses
- 4 locations
- 2-3 docs/day
- gt3,000 sedations/year
6Overview
- Definitions
- Choose wisely
- Pick your patient
- Pick your drugs
- Pick your nos
- Pick your battles
- On the horizon
7Definitions
- 1992 AAP (Peds 1992898110)
- Conscious Sedation
- Deep Sedation
- 1998 ACEP (Ann Emer Med 199831663)
- Procedural Analgesia Sedation
- 2006 AAP AAPD (Peds 20061182587-2602)
- Minimal anxiolysis
- Moderate conscious
- Deep
- General anesthesia
8Joint Commission 2000
- Level 1 Minimal
- Respond normally to verbal commands
- Cognitive function and coordination impaired
9Joint Commission 2000
- Level 2 Moderate sedation / analgesia
- Respond to verbal or gentle tactile stimuli
- No intervention to maintain airway
- Adequate spontaneous ventilation
10Joint Commission 2000
- Level 3 Deep sedation / analgesia
- Respond purposefully following repeated or
painful stimulation - Ability to maintain ventilatory function may be
impaired
11Never Never Land
- Level 3.5 Dissociative Sedation
- Cataleptic state
- Maintain protective reflexes
- Retain spontaneous respirations
12Joint Commission 2000
- Level 4 Anesthesia
- Not arousable, even with painful stimuli
- Independent ventilatory function often impaired
13Remember, its a
CONTINUUM
14Providers
- Licensed independent practitioner
- Know drugs and antidotes
- Ability to monitor
- Capable of rescue
- Re-assess immediately before sedation
- Immediately available
- Not doing the procedure
15(Appropriate) Patients
- Painful Procedures
- Bone marrow Bx, BMA
- Wound debridement
- Renal Bx
- Abscess ID
- Fracture reduction
- Cardioversion
- Movement an issue
- Suture difficult area
- Radiographic images
- Auditory brain response
- LP
- Casting
16Inappropriate Patients
- Airway issues
- Small, tight jaw
- Airway obstruction
- Respiratory issues
- Super quick
- Lacerations to be fixed with Dermabond
Primum non nocere
17Airway concerns
- Downs Syndrome
- Macroglossia
- Small mouth
- Small trachea
- Atlanto-axial instability
18Airway concerns
Pierre-Robin Sequence
Beckwith-Wiedemann Syndrome
19Other concerns
- Pneumonia, asthma, BPD, tracheomalacia, OSA,
tachypnea - CCHD, CHF, hypotension
- Central apnea, seizures
- GERD, hepatic disease
- Renal disease, dehydration, abnormal electrolytes
- Sepsis
20Patient Assessment
- American Society Anesthesiology (ASA) class
- Allergies
- NPO status
- Health evaluation
21ASA classes
- ASA 1 Healthy
- ASA 2 Controlled dz of 1 system lt1 yo healthy
- ASA 3 1 major system, poorly controlled
- ASA 4 1 severe dz, end-stage, constant threat
to life - ASA 5 Moribund, imminent death
22Allergies
- Medications allergies
- Previous anesthesia events?
- Food allergies (egg, soy)
- Tape, skin prep, etc
23NPO duration adverse events
- Agrawal (2003) 1,014 sedations
- 8.1 in fasted, 6.9 unfasted
- Roback (2004) 2,085 sedations
- No correlation by fasting time
- Treston - 334 echos lt6 mos (ketamine)
- Fewer events if fasted lt3 hours
- Ingebo (1997) 285 gastroscopies
- No correlation of gastric volumes by times
24NPO Status
- because the absolute risk of aspiration during
procedural sedation is not yet known, guidelines
for fasting periods before elective sedation
should generally follow those used for elective
general anesthesia.
Pediatrics 20061182587
25NPO status (ASA)
- Solids, formula - 6 hours
- Clear liquids - 2 hours
- Breast milk - 4 hours
- Can take sip with meds
26Preparation
- Informed consent
- Health evaluation
- ROS
- History (sedations?)
- Medications (including herbals)
- Weight
- VS, sat
- Exam (airway, lungs, CV state, LOC)
27Preparation
- Additional person
- SOAPME
- Suction
- Oxygen
- Airways (BVM, oral, LMA, ETT)
- Pharmacy (meds)
- Monitors
- Equipment (defibrillator, airway supplies, etc)
28Reversal Agents
- Naloxone
- Competitively binds all 3 opiate receptors
- IV, IM, SC, SL, ETT
- 0.1 mg/kg
- Flumazenil
- Can terminate paradoxical reactions
- 0.02 mg/kg
- Lowers seizure threshold
29Documentation Monitoring
- Time out
- Time-based record Q5 minutes
- SPO2 ETCO2
- HR
- BP
- LOC
- O2 given
- Medications
- Interventions
30Recovery and Discharge
- Continuous HR sats until alert
- 1 person dedicated to patient
- Aldrete post-anesthetic score
- Post-sedation evaluation
- Baseline cardiopulmonary status (VS)
- Drinking
- Level of consciousness
- Locomotion / sitting
- Written verbal instructions
31(No Transcript)
32Git er done
- Hypnotics
- Sedatives
- Ketamine
- Etomidate
- Propofol
- Nitrous oxide
33Midazolam (Versed)
- Anxiolysis
- Dose-
- 0.05-0.1 mg/kg IV, onset min
- 0.5-1 mg/kg PO, onset 20-30 min
- 0.3-0.4 mg/kg IN, onset 5-15 min
- Amnesia 92 - 98
- Paradoxical reactions
- 1.4 emergence / atypical reaction
- onset at 14 min
- relieved with flumazenil
34Hypnotics
- Chloral hydrate
- Pentobarbital
- Methohexital
- Etomidate
35Chloral hydrate
- Mickey Finn
- 50-80 mg/kg PO
- Onset approximately 15 minutes
- Duration 1-2 hours
- Total max dose of 120 mg/kg or 1 g total for
infants and 2 g total for children
36Chloral hydrate
- Amnesia?
- Gas
- Hyperactivity
- Deaths after discharge
- Carcinogen
37Barbiturates
- Depress RAS
- No analgesia
- May be hyperesthetic
- Amnesia
38Pentobarbital (Nembutal)
- 1-3 mg/kg IV, up to total of 6 mg/kg
- Sleep onset 1-2 minutes
- Duration 30-60 minutes
- Hypoxia, hypotension
- May give IM 4-6 mg/kg
- Rage reaction 1.6
39Methohexital (Brevital)
- 1-3 mg/kg IV
- Not painful
- Additional doses at 0.5 mg/kg
- Drip 3 mg/kg/hr
- Sleep onset 1-2 min
- Duration 10-20 min
- IM, PR 90 minutes
- 25 mg/kg PR
- 5-10 mg/kg IM
40Methohexital
- IV
- Myoclonus 10
- Hiccups 10
- Rectal
- 95 success
- 6 apnea / desaturation
- 3 hiccups
Pediatrics 2000105(5)1110-4
41Etomidate
- Ultrashort-acting non-barbiturate imidazole
hypnotic - 0.2-0.3 mg/kg (lt10 yrs), 0.2-0.6 gt10 yrs
- Give over 30-60 sec
- Onset 30 sec
- Duration 5-10 min
- Negligible hemodynamic effects
- Amnesia 80
42Etomidate
- Myoclonus up to 30
- Pain at injection site
- No analgesia
- Adrenal suppression
- Blocks the normal stress-induced increase in
adrenal cortisol production for 4-8 hours - Increases EEG activation
43Pentobarbital vs. Etomidate
Adverse Event Pentobarb N 396 Etomidate N 444 Relative Risk (95 CI), p
Any Event (p.005) 18 (4.5) 6 (0.9) 1.03 (1.01,1.05)
Desaturation 4 0 p0.03
Inadequate sedation 3 2 NS
Apnea 2 1 NS
Allergy/cough/secretions 4 0 NS
Prolonged sedation 3 1 NS
Stridor 1 0 NS
Emesis 0 1 NS
Too Deep 1 0 NS
not ideal 11 1 plt0.003
Recovery time (min) 144 (139,150) 34 (32,36)
44(No Transcript)
45Ketamine
- Dissociative state
- Related to PCP
- Disconnects limbic system
- Brainstem RAS not affected
- Analgesia Sedation Amnesia
- Does not impair laryngeal reflexes
- Bronchodilation
- ?inotropy, ?BP, ?SVR
46Ketamine
- 1-2 mg/kg IV, drip 1-2 mg/kg/hr
- 3-7 mg/kg IM
- Onset 1 min (nystagmus)
- Duration 15 min to 1 hour
47Ketamine
- ? Secretions
- Consider glycopyrrolate (Robinul)
- Vomiting
- Emergence 12
- Contraindications
- ? ICP, glaucoma, open globe
- lt3 months of age
- History of psychosis, porphyria
48Propofol
- Sedative-hypnotic
- 1-3 mg/kg bolus over 2 min
- 5 mg/kg/hr
- Infants need higher dose
- Sedative
- Profound relaxation
- Anti-emetic
- Antiepileptic properties
- Fidget ? Yawn ? Out ? ??
49Propofol
- Alkaline -- STINGS
- Contraindicated - egg or soy allergy
- Hypotension
- Rare bradycardia, acidosis leading to sudden
death - No analgesia
- Green urine
50Propofol in kids
- Guenther (p. 783)
- 291outpatients
- Median dose 3.5 mg/kg
- 4 jaw thrust
- 1 BVM
- 1 bradycardia to 57
- Bassett (p. 773)
- 393 patients
- Median dose 2.7 mg/kg
- 3 jaw thrust
- 8 prolonged BP ?
- 0.8 BVM
- 5 hypoxia
Ann Emerg Med 200342783 773
51Nitrous Oxide (NO2)
- Sedative analgesic
- FiO2 0.25-1.0
- 50 nitrous maximum
- In combo with ANY other sedation or narcotic
deep sedation - Need scavenger equipment
- 1015 vomiting
52Dexmedetomidine
- a2-adrenergic receptor agonist
- Sedative analgesic effects
- Non-invasive procedures in 48 kids
- 15 after failing CH and/or midazolam
- Dosage
- 0.5-1.0 mcg/kg over 5-10 min
- Infusion 0.5-1.0 mcg/kg/hr
- Recovery (w/o other med) 69 34 min
- Minimal cardio-respiratory effect
PCCM 20056435-9
53Adverse events
- gt30,000 ped sedations (26 hospitals)
- All providers, non-OR
- 50 propofol
- Docs 28 ER, 28 ICU, 19 anesth.
- 0 deaths, 1 arrest, 1 aspiration
- Per 10,000 sedations
- 24 apnea
- 2 airway consult
- 10 intubation
- 27 oral airway
- 7 admitted
- 64 BVM
Peds 20061181087
54Reducing errors
- Fewer than 3 medications
- Experience
- Double check dosages
- Expect adverse events
- Ready to rescue!
55Just say no
- Music
- Video
- Quiet room
- Darken if possible
- Parents present
56Goals Sedation outside the OR
- Guard safety welfare of child
- Minimize physical discomfort pain
- Control anxiety, maximize potential for amnesia
- Control behavior movement to complete procedure
- Return patient to state safe for discharge
57Meetings
- Pediatric Sedation Outside the Operating Room
- Boston
- September 15-16, 2007
- 2nd International Multidisciplinary Conference on
Pediatric Sedation - Savannah, GA
- March, 2008
- Society for Pediatric Sedation
58Questions?