Pharmaceutical Dosage Forms

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Pharmaceutical Dosage Forms

• Suwannee Panomsuk
• Department of Pharmaceutical Technology
• Faculty of Pharmacy, Silpakorn University

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?????????????????????????Department of
Pharmaceutical Technology
Pharmaceutical Technology 1 (1)
Introduction 1-2 Pharmaceutical Technology 2
(3) Lab (1) Solid dosage forms 2-1 Pharmaceutica
l Technology 3 (2) Lab (1) Solutions
2-2 Pharmaceutical Technology 4 (2) Lab
(1) Semisolid 2-2 Pharmaceutical Technology 5
(2) Lab (1) Sterile 3-1 Pharmaceutical
Technology 6 (1) Special dosage forms 3-2
1-2 ?? 1 ???? 2
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Figure 1. Electron micrograph of influenza A
virus particles.Provided by M-T. Hsu and P.
Palese.
Influenza old and new threats Peter Palese
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Figure 2.
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Figure 3.  Inhibition of influenza virus
replication cycle by antivirals.
http//www.nature.com/nm/journal/v10/n12s/fig_tab/
nm1141_F4.html
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Oseltamivir
Figure 4.
????????????????????????????????????????? host
cell ??? Antiviral Drugs
http//sophia.smith.edu/blog/rdorit/2009/05/06/rem
embrance-of-viruses-past/
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Figure 5. Influenza A viruses circulating in the
human population.
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Figure 6.
???????????? Oseltamivir
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Fig. 7. Star anise fruits (Illicium verum)
Wikipedia, the free encyclopedia
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??????????????????????
5. ????????????????????? Pharmaceutical
Technology
6. ????????????????? Community Pharmacy,
Pharmaceutics
Figure 8.
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Figure 9. ????????????????
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???????? 1 ?????????????????????????????
Drug Usual Dose (mg)
Category Acetaminophen 500 Antipyritic,
Analgesic Ferrous Sulfate 300
Hematinic Amoxycillin 250 Antibacterial Morph
ine Sulfate 10 Narcotic analgesic Prednisolo
ne 5 Steroid Chlorpheniramine
Maleate 4 Antihistamine Digoxin
0.25 Cardiotonic Ethinyl Estradiol 0.05
Estrogen

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????
Paracetamol tablet 500 mg
?? (Drugs)
???????? (Pharmaceutical Dosage Forms)
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Routes of administration
Oral Eyes, ears, nasal (nose) Topical
(skin) Rectal Parenteral (injection) Respiratory
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Dosage forms for different administration routes
Oral solutions, syrups, suspensions,
emulsions, gels, powders, granules, capsules,
tablets Rectal suppositories, ointments, creams,
powders, solutions Topical ointments, creams,
pastes, lotions, gels, solutions, topical
aerosols, patch Parenteral injections
(solutions, suspensions, emulsions), implants,
irrigation and dialysis solutions
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Respiratory aerosols (solutions,
suspension, emulsion and powder forms),
inhalations, sprays, gases Nasal solutions,
suspensions, inhalations Eye solutions,
suspensions, ointments, creams Ear solutions,
suspensions, ointments, creams
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???????????????????????
1. Purity ???????????????????? 2. Uniformity
3. Efficacy ??????????????????????? 4.
Safety 5. Stability 6. Palatability ?????? 7.
Convenience ????????
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???????????? Dosage Forms
1. Active ingredients
2. Pharmaceutical necessities
Vehicle.Liquid Base.Semisolid
Diluent.Solid
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Formulations (?????????)
Rx ??? ?????? 1. Active
Ingredients 2. Pharmaceutical
necessities ...Vehicle,
Diluent ????????? ..........................
.... ?????????? ............................. ??
?????????? ......................
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Pharmaceutical necessities (???????????)
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Oral Rehydration Salts (ORS) Rx Sodium
chloride 3.5 g Trisodium citrate
dihydrate 2.5 g Potassium chloride 1.5 g Glucose
anhydrous 20.0 g Color Flavor qs.
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The Need of Dosage Forms

• Accurate dose ?????????????
• Protect drug from instability
• ???????????????.???????????/??? ???????
• 3. Odor and test ???????? ?? ????????????????
• Drug with limited solubility
• ???????????????????? .. ???????? ?????
• 5. Palatibility ??????? ?????
• 6. Right purpose ??????????????????????????
• For Identification
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1. Pharm. Tech. 1.
2. Pharm. Tech. 3 (lab)
4. Pharm. Tech. 4 (lab)
3. Pharm. Tech. 2 (lab)
5. Pharm. Tech. 5 (lab) 6. Pharm. Tech. 6
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5. ???????? ?????????????? 6.
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End of this part