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I-SPY 2 Breast Cancer Clinical Trial Participant
Website

• Home
• More Information
• about I-SPY 2
• Participating
• Cancer Centers
• Peer Support
• for I-SPY 2
• Participants
• More Information
• About Breast
• Cancer

The I-SPY 2 TRIAL is a clinical trial that is
designed to test several investigational drugs
for breast cancer. The goal of this trial is to
quickly learn which patients are most likely to
benefit from these investigational by learning
about each patients cancer biology and using
imaging techniques.
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I-SPY 2 Breast Cancer Clinical Trial Information
about I-SPY 2

• Home
• More Information
• about I-SPY 2
• Participating
• Cancer Centers
• Peer Support
• for I-SPY 2
• Participants
• More Information
• About Breast
• Cancer

Commonly Asked Questions about the I-SPY 2
TRIAL How does the I-SPY 2 TRIAL work? What
is a biomarker and how are they being used in
I-SPY 2? What is a MRI scan and what does it
mean to me? What is a core biopsy and what does
it mean to me?
Investigation of Serial studies to
Predict Your Therapeutic Response
with Imaging And moLecular analysis
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I-SPY 2 Breast Cancer Clinical Trial Information
about I-SPY 2

• Home
• More Information
• about I-SPY 2
• Participating
• Cancer Centers
• Peer Support
• for I-SPY 2
• Participants
• More Information
• About Breast
• Cancer

Commonly Asked Questions about the I-SPY 2
TRIAL What happens if I consider joining the
I-SPY 2 TRIAL? How do I know if I am eligible for
the I-SPY 2 TRIAL? What biomarkers will be used
to see if I am eligible for the I-SPY 2
TRIAL? What is MammaPrint? What MammaRrint
score do I need to participate in I-SPY 2? Why
will I receive treatment before surgery in I-SPY
2? Why will I receive 2 different chemotherapy
treatments? If I agree to be in I-SPY 2, how soon
will I be able to start my treatment? How likely
am I to receive an investigational drug if I join
I-SPY 2? If I do receive an investigational drug,
who pays for the investigational drug, what
will it be, and what are the potential short and
long term side effects? How many MRIs will I have
and how long will each one take? Who will pay for
the MRIs that I will have? How many times will
tissue be collected, who will pay for the
collection, and how will the tissue be
collected? How many times will my blood be
collected, who will pay for the collection, and
how will the blood be collected? What will my
tissue and blood samples be used for? Will I be
told the results of the tests done from my tissue
and blood samples? If I join I-SPY 2, how long
will I be in the study? If my cancer does not go
away completely after neoadjuvant treatment, what
options are available to me for additional
treatment? This trial is called I-SPY 2. What was
I-SPY 1 and what was learned from it? Whom may I
contact if I have additional questions about
I-SPY 2?
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I-SPY 2 Breast Cancer Clinical Trial Information
about I-SPY 2 TRIAL

• Home
• More Information
• about I-SPY 2
• Participating
• Cancer Centers
• Peer Support
• for I-SPY 2
• Participants
• More Information
• About Breast
• Cancer

• Commonly Asked Questions about the I-SPY 2 TRIAL
• What happens if I consider joining the I-SPY 2
  TRIAL?
• How do I know if I am eligible for the I-SPY 2
  TRIAL?
• What biomarkers will be used to see if I am
  eligible for the I-SPY 2 TRIAL?
• What is MammaPrint?
• What MammaRrint score do I need to participate
  in I-SPY 2?
• Patients that participate in I-SPY 2 are women
  that we think will likely benefit from
  chemotherapy.
• For this trial, your cancer needs to be one of
  the following to be eligible
• MammaPrint High Risk Score
• MammaPrint Low Risk Score and ER negative
• MammaPrint Low Risk Score and ER positive and
  Her2 positive
• If your cancer does not match one of the above
  groups, you will not be eligible to join the
  I-SPY 2 TRIAL. Please discuss other treatment
  options with your doctor.
• Why will I receive treatment before surgery in
  I-SPY 2?
• Why will I receive 2 different chemotherapy
  treatments?
• If I agree to be in I-SPY 2, how soon will I be
  able to start my treatment?
• How likely am I to receive an investigational
  drug if I join I-SPY 2?
• If I do receive an investigational drug, who pays
  for the investigational drug,
• what will it be, and what are the potential
  short and long term side effects?

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I-SPY 2 Breast Cancer Clinical Trial Cancer
Centers Participating in I-SPY 2

• Home
• More Information
• about I-SPY 2
• Participating
• Cancer Centers
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• Cancer

Here is a list of Cancer Centers that are
enrolling patients in the I-SPY 2 TRIAL Show
Map of US/etc with sites- allow user to click on
centers logo and be directed to their website
(either main university site or sites breast
care center site) You can also visit
www.breastcancertrials.org to check your
eligibility for I-SPY 2 or other clinical trials
in your area.
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I-SPY 2 Breast Cancer Clinical Trial Peer Support
for I-SPY 2 Participants

• Home
• More Information
• about I-SPY 2
• Participating
• Cancer Centers
• Peer Support
• for I-SPY 2
• Participants
• More Information
• About Breast
• Cancer

A peer support network is available to all I-SPY
2 Participants. Please check with _________ for
local services that are available for
you. Breast Cancer Network of Strength has a
hot-line you can call, 1-800-221-2141, at any
time and tell them you would like to speak to an
I-SPY 2 counselor. They will take your contact
information and arrange to have someone return
your call within 48 hours.
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I-SPY 2 Breast Cancer Clinical Trial More
Information about Breast Cancer

• Home
• More Information
• about I-SPY 2
• Participating
• Cancer Centers
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• for I-SPY 2
• Participants
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• About Breast
• Cancer

To find out more about cancer and breast cancer,
please visit the websites listed below. National
Cancer Institute (NCI) website www.Cancer.gov NCI
Educational Material on Clinical Trials
http//www.cancer.gov/clinicaltrials/learning NCI
Dictionary of Cancer Terminology http//www.canc
er.gov/dictionary/