Presentaci

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Research Programme on Biomedical
Informatics (GRIB)
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What is the GRIB?

• GRIB is a research programme of both Universitat
  Pompeu Fabra (UPF) and IMIM.
• IMIM is the research institute ofHospital del Mar
  (PSM)and it is academically affiliated to the
  UPF.
• GRIB is located in the Biomedical Research Park
  of Barcelona (PRBB).
• GRIB is also the Biomedical Informatics node of
  the Spanish Institute of Bioinformatics (INB).

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GRIB Mission
TICs and computational approaches are mandatory
tools for managing and exploiting the immense
amounts of data that are currently generated in
the biomedical research (experimental, clinical,
epidemiological).
Mission To invent, develop and apply
computational methods that, through an intensive
use of and information technologies, allow a
better understanding and prediction of biological
phenomena, giving especial emphasis to those
related to the human diseases and their treatment.
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GRIB themes and organisation
GRIB is organised in six thematicin silico
labs Computational Genomics Computational
analysis of genomic sequences and information.
PIs M. Albà, E. Eyras, N. Lopez-Bigas R.
Castelo. Structural BioinformaticsAnalysis and
modelling of protein structures and interactions.
PI B. Oliva. Computational Biochemistry and
BiophysicsModelling and simulation of
biophysical and biochemical phenomena at
molecular and systemic scales. IPs J.
Villà-Freixa and G. de Fabritiis. Chemogenomics
Computational annotation and analysis of massive
molecular DBs vs. protein families showing
therapeutic interest. IP J. Mestres. Computer-Ass
isted Drug DesignMolecular modelling and
multivariate statistical analysis in the drug
RD. IPs M. Pastor, J. Selent I. Zamora (part
time) Integrative Biomedical InformaticsIntegrati
ve knowledge management in biomedical research.
IP F. Sanz. Management office.Manager C. Donlo
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The GRIB team

• The GRIB staff is a multidisciplinary team of 70
  professionals (20PhDs), which includes
• biologists,
• pharmacists,
• chemists,
• physicians,
• computer scientists,
• mathematicians
• research management staff

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GRIB research outcomes
Without including Complex System Lab.
publications
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GRIB research outcomes

• Average IF of the journals of GIB publications
  (2005-09) 5.33
• No. of citations of papers published in 2005-07
  1668

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GRIB research outcomes

• GRIB develops open source and proprietary
  software that is internationally recognised.
• GRIB research has generated two spin-off
• Pharmatools
• Chemotargets

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Integrative knowledge management in
pharmacovigilance
30M EHRs from 4 EU countries !

• Literature mining
• in silicosimulation
• Pathway analysis
• Genetic polymorphisms

www.alert-project.org
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Workflows for chemo- bio-informatics signal
substantiation
Possible drug AE relationship
Drug
Adverse event
to be assessed
Biological pathways
Drug metabolites
Involved proteins
Similar drugs-ligands
Genetic variants (SNPs)
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GRIBs strategic priority

• The GRIB aims to enhance its biomedical focus,
  putting the emphasis in the clinical application
  of the bioinformatics and knowledge management
  approaches that it develops.
• In particular, we are currently developing a
  strategic collaboration with Hospital del Mar
  (PSM)on the research exploitation of its clinical
  information system (IMASIS).

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