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High-Throughput Analysis of Genomic Data [S3] ENRIQUE BLANCO

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High-Throughput Analysis of Genomic Data [S3] ENRIQUE BLANCO NUMBER OF SLIDES: 5 EXPECTED TIME: 15 minutes THE GENOME REGULATORY LANDSCAPE EPIGENETICS: THE HISTONE ... – PowerPoint PPT presentation

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Title: High-Throughput Analysis of Genomic Data [S3] ENRIQUE BLANCO


1
High-Throughput Analysis of Genomic Data S3
ENRIQUE BLANCO
NUMBER OF SLIDES 5 EXPECTED TIME 15 minutes
2
THE GENOME REGULATORY LANDSCAPE
Molecular Biology of the Cell (5th edition) .
Alberts et al. Garland Science (2008). ISBN-13
978-0815341055
The complex transcription regulatory landscape of
our genome control in 3D. E. Splinter and
W.Laat. The EMBO Journal (2011) 30 4345 4355.
3
EPIGENETICS THE HISTONE CODE
Adapted from www.abcam.com
4
COMPUTATIONAL PREDICTION OF TFBSs
JASPAR 2010 the greatly expanded open-access
database of transcription factor binding
profiles. E. Portales-Casamar et al. Nucleic
Acids Research 38D105-D110 (2010).
Computational characterization of regulatory
regions. E. Blanco in Algorithms in
Computational Molecular Biology Techniques,
Approaches and Applications. Wiley-Blackwell
(John Wiley Sons Ltd). ISBN-13 978-0470505199
(2010).
5
PHYLOGENETIC FOOTPRINTING
100
0
Computational characterization of regulatory
regions. E. Blanco in Algorithms in Computational
Molecular Biology Techniques, Approaches and
Applications. Wiley-Blackwell (John Wiley Sons
Ltd). ISBN-13 978-0470505199 (2010).
6
ACTIVE AND POISED ENHANCERS
D. Melanogaster - E12h-E16h
Regulatory areas
E. Blanco and M. Corominas. CBS an open platform
that integrates predictive methods and
epigenetics information to characterize
conserved regulatory features in multiple
Drosophila genomes . BMC Genomics 13688 (2012).
7
High-Throughput Analysis of Genomic Data S3
ENRIQUE BLANCO
NUMBER OF SLIDES 5 EXPECTED TIME 15 minutes
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