xGenCloud

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xGenCloud
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xGenCloud

• Cloud service intended for automatic
  interpretation of genetic tests results, allows
  to form detailed genetic conclusion.

Authors and developers Igor Ugarov, MD, PhD
e-mail
iugarov_at_yandex.ru

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Business model I
xGenCloud

• NEEDS OF CLIENTS WHICH WILL BE PROVIDED BY
  SERVICE
• Automatic formation of the individual list of
  necessary genetic analyses for the patient
  depended on his (her) phenotype, family history,
  drug consumption, and environmental factors.
• Automatic interpretation of genetic tests results
  and formation of detailed genetic conclusion.

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Business model II
xGenCloud
ADVANTAGES OF USING xGenCloud SERVICE FOR
BUSINESS OF CLIENTS

1. Increasing of sales volume of genetic analyses
2. Decreasing of expenses for clinical geneticist in
   staff of clients business
3. Development of such modern and perspective field
   of knowledge as predictive (personalized)
   medicine allows clients business to remain
   competitive
4. Increasing of sales volume of all other services
   offered by medical center (medical consultations
   by doctors of various specialties, other
   laboratory tests, and instrument investigations)
   this will be provided by including special
   recommendations in every genetic conclusion for
   the purpose of prevention of this or that complex
   disorder.

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xGenCloud
Business model III
PRICE POLICY Monthly fee 1. Payment for
automatic formation of list of required genetic
tests. 2. Packages of certain number of
interpretations of genetic tests results. It is
also possible to pay for each interpretation
The price is depended on number of tested genes
(polymorphisms).
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xGenCloud
Business model IV
SCENARIO OF SERVICE USING Medical consultation
of patient by the doctor of certain medical
center (hospital). ? Using service xGenCloud
during consultation the doctor gets individual
list of genetic tests (genes and polymorphisms)
which should be done for the patient depending on
phenotype, family history, drug consumption, and
environmental factors (all these factors need to
be entered into the software). ? According to the
list of administered genetic tests patient sample
is analyzed by any genetic laboratory. ? After
receiving genetic results the doctor enters
results into the software xGenCloud and gets
automatically generated detailed genetic
conclusion which explains him what kind of
genetic predisposition his patient has and what
should be done to prevent the disease. ? Finally
patient receives text file with genetic
conclusion which includes individualized
recommendations regarding supervision and
examination by certain doctors , also list of
additional laboratory tests and instrument
investigations which should be carried out to
decrease risk of the disease. As a result
patient continues to attend medical center
(hospital) on regular basis.
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MARKETING STRATEGY
xGenCloud

• POTENTIAL CLIENTS
• Genetics laboratories
• Medical-genetic consultations
• Research institutes
• Medical centers offering genetic testing
• Hospitals (centers) of reproduction
• Centers of anti-age medicine
• Sanatoriums
• Other

The system is intended to help doctors of various
specialties who consult patients with common
disorders (multifactor diseases), allows to test
patients for genetic predisposition correctly and
to receive automatically generated conclusion by
results of genetic testing.
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ADVANTAGES
xGenCloud

• BASIC ADVANTAGES OF xGenCloud AGAINST
  COMPETITORS
• Complex data analysis
• Using of possible data maximum
• The most extensive database
• Constant updating of the service
• More than 10 years experience in the field of
  development
• of software for medical genetics
• More than 5 years experience in the field of
  predictive medicine
• The volume of interpretations is not limited
  (service can provide as much
• interpretations as clients business needs)

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DESCRIPTION I
xGenCloud

• Catalog of signs includes 10 000 terms and
  allows to describe in detail phenotype of the
  patient. Catalog of diseases which intended to
  describe family history includes more than 3000
  nosological forms.
• More than 2000 pharmacological drugs are
  included in the medicines catalog. All drugs are
  in terms of INN (international nonproprietary
  names) which allows to define medicine exactly
  and to consider its active components.
• Catalog of environmental factors allows to
  consider habits, life-style of the patient, and
  influence of various exogenous factors on
  development of multifactor diseases.
• Catalog of genes gives information about 20000
  genes, 6000 genes are described with their
  associations with different diseases.
• Use of gene networks allows to consider
  interaction between genes in algorithm of
  selection for DNA diagnostics.

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DESCRIPTION II
xGenCloud
Program based on platform xGen IDS which
is registered in the State register of programs ?
2008612260 May 07, 2008
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EXAMPLES I
xGenCloud
Examples of input of phenotype signs, family
history, and prescribed medicines
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EXAMPLES II
xGenCloud
Result of genes selection in the form of list
after entering certain parameters
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EXAMPLES III
xGenCloud
Catalog of gene networks (example of searching
for gene network of an acute nonlymphocytic
leukemia)
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EXAMPLES IV
xGenCloud
Catalog of genetic associations
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AUTOMATICALLY GENERATED GENETIC CONCLUSION
xGenCloud
xGenCloud
TEXT FILE WHICH CONSISTS

• 1. Introduction (short description of genetic
  testing carried out for the patient)
• 2. Table with results of genetic analyses (genes,
  rs, genotype, etc)
• 3. List of practical recommendations regarding
  prevention of diseases to which genetic
  predisposition is revealed
• 4. Scientific explanation of interpretation of
  genetic results
• 4.1 Short description of all analyzed genes
  and their polymorphisms
• 4.2 Frequency of revealed genotypes in
  population
• 4.3 Terminological dictionary
• 4.4 References.

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EXAMPLE of INTERPRETATION (fragment of short
description of gene)
xGenCloud
Cardiovascular system F2 Gene F2 is localized on
the 11th chromosome (11p11-q12) and encodes
factor of coagulation II prothrombin. It is one
of key factors of blood clotting. The most
significant and discussed in literature
polymorphism of DNA in F2 gene is G20210A.
Polymorphism is situated in 3 untranslated
region of the gene and influences at mRNA level
leading to increasing of prothrombin
concentration in blood plasma. However among
heterozygous carriers of risk allele prothrombin
level varies very much, therefore simple
quantitative analysis of this marker in blood
can't be used for diagnostics of prothrombin
thrombophilia. Result Polymorphism G20210A is
not found (genotype G/G). Frequency of allele
20210A in European population is 3 . Found
genotype is prevailing in population. Prothrombin
is one of the main components of coagulative
system of blood. At the first stage of process of
coagulation prothrombin turns in thrombin by
photolytic cleavage and finally promotes
formation of fibrin in blood clotting process.
Presence of risk allele in F2 gene is
characterized by increased level of prothrombin
in blood and is associated with increased
relative risk of development of thrombosis and as
a consequence with increased risk of myocardial
infarction and ischemic stroke. Conclusion In
gene F2 requied polymorphism which increases risk
of thrombosis isn't found.
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xGenCloud
Authors and developers Igor Ugarov, MD, PhD
e-mail
iugarov_at_yandex.ru