Stroke Research at the RUH

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Stroke Research at the RUH

• Service development

Barbara Madigan, Denise Button, Dr Louise Shaw,
Claire Fullbrook-Scanlon
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Overview

• How we started
• Identifying patients and recruitment
• Portfolio management
• Statistics
• The Future

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At the very beginning

• Originally established by Dr. Shaw/ Claire
  Fullbrook-Scanlon, recruiting 11 patients to one
  commercial study (PERFORM) (2006),
• Then one part time Research Nurse working 2
  days/week running PERFORM, recruiting to CLOTS
  (11 patients), setting up of IST3 (2008).

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Next stage June 2009 - date
IRIS

• 1 FTE Research Nurse
• Setting up of further trials
• Acute phase (IST3, SOS, INTERACT2, ENOS)
• Genetic (DNA lacunar)
• Preventative (CADISS, IRIS, TARDIS, PODCAST)
• Observational (CROMIS2)

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Identifying patients/recruitment

• Mon-Fri 9-5
• Screen all patients admitted with diagnosis of
  Stroke/TIA/ICH
• Patients seen in TIA clinic/Stroke Clinic
• Research Letter
• Noticeboard/sign on ward
• ED staff recruit

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Particularly helpful

• Being part of clinical team
• Easy access to and approachable PI Stroke
  Consultants
• Good relations with RD
• ED very proactive in recruiting
• Collaborative working Diabetes/lipid. ED,
  Orthoptist

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Portfolio Management

• Good variety of studies (acute/long-term/genetic)
  aids recruitment
• Can be restricted by availability of appropriate
  studies.

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Successes

• 92 patients recruited since 2009
• Randomised first UK patients to IRIS and CROMIS 2
  studies
• Current top UK recruiters IRIS and INTERACT2
  trials

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Cumulative Recruitment
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Future

• Embed Research into clinical practice
• Encourage clinical staff to embrace Research as
  part of their practice by training staff in
  GCP/trial related procedures
• Research Nurses transition from pure recruiters
  to facilitators of research