METAL TOXICITY IN

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• METAL TOXICITY IN
• BIOMATERIAL
• ???? ????????
• ???????? ???? ?????????
• ??????? ????? ????????- ??????? ?????? ?????
• ???? 89

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(No Transcript)
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?????  ??? ????? ????? ?? ?????? ?????
(PH7/35-7/45) ? ?????? ??? (?????)? ??????? ???
(?????? ? ???? ???????? ? ...) ???? ????? (????
??? ????????? ??? ? ...) ? ?????? ???? ?????
(?????? ?????? 0/96-1/00( ???? 10/0-13/3KPa ???.
?????? ????? ????? ??????? ((PH ??????? ????? ??
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????? ????? ????? ????? ? ?? ????? ????? ???????
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  ???????? ???? ? ?????? ?? ???? ?????? ?? ????
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• ????? ???? ????? ????? ??? ?? ???? ?? ?? ???
  ????????? ????????. ?? ???? ????? ????? ?? ??????
  ?? ??? ????????? ??? ???? ??? ??????? ??? ???????
  ???????. ???? ??? ???? ???? ???????? ? ?????
  ?????? ?? ??? ?????.

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????????TITANIUM
Symbol Ti
Atomic Number 22
Atomic weight 47.9u
Color Silverish
Electron configuration Ar3d24s2
Titanium dental implant
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Application ?? Medical

• ???????? ?? ????? Bone plates, pace makers, knee,
  hip ? ??? ?????? ?????(??????? ??????
  ?????)??????? ???????????? ???? ?????.
• ????????????? ????? ????????? ???? ??? ??? ???
  ????? ?????? ?? ????? ????? ???.

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• ???????? ????? ???????????? ???? ??????? ,?????
  ??????????? ????? Biocampatible ???? ????? ?????
  ????? ?? ????
• ??? ??? ?????? ???? ???? ?? ?????? ????? ?????
  ????? ????? ??? ???? ???

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• ?????? ????? ???? ?? ????? ???????? ???? ???? ??
  ?????? ?????? ??? ??? ???? ??? ????? ??? ???? ??
  ??? ?? ????? ???? ????? ??? ?? ????? ?????? ???
  ????????? .
• ????? ??? ?? ??? ??? ???? ??? ?????? ???????
  ????? ????? ?? ??? ?????? ???? ?? ??????? ????
  ??? ?? ?? ??? ????? ?????? ??? ??? ???? ?????? ??
  ??? ????? ?? ??? ????? ??????? ????.

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??? ??????? ?????? ?? ??????????????? ?????
?????? ????? ???? ? ??? ??????? ????????? ???
??????? ???????.

• ???????? ????? ?? ???? Apoptosis ????? ????
  ?????????? ????? ????? ?????(Tumor suppressor
  proteins) ?? ?????? ???? ??? ??? ??????? ???????
  ???? ????? ??????????? ???? ????? ???.
• ????????? ??? ????? ???? ?? ?????? ??? ????? ??
  ?? ????? ???????? ???? ???? .

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??????????? ?????? ??? ??? (Rats ) ????
???????? ?? ?????? over dose ?? ???? ????????
???? ????? ???? ??? ??? ???? ????? ????? ??? ???

• ??????? ?? ??? ????????? ?? ??????????? ????? ??
  ???? ???? ???? ???? ???? ????? ??? ??? ???? ????
  ???? ????? ??????? ?? ??? .
• ??? ??? ????? ????? carcinogenicity ?? ?? ?????
  ???? ???.

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????????? ?????? ??????? ???????? ???
???????,??????,??????? ????? ????? ?????????
????????? ??? ????? ?? ????? ?? ????? . ????????
?????? ???? ?????? ???? ? ????? ???? ???? ??????
?? ??? ?? ??? ??? ???? ??? ????????? ?????
???????????? ?? ???????????? ??? ??? ?? ????? ???
????? ?????? ???? ???
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????? ? ????? ??? ???? ?? ???? ??? ??????????
???????? ????? ????? ???? ??? ??? ?????? ??
???????? ??????????? ?? ???? ?? ??? ???? ?????.
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?? COPPR
Atomic Weight   63.546
Density   8.92 g/cm3
Atomic Number   29
Symbol cu
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????? ????? ?? ?? ??? ??????? ??

1. Copper Cookware
2. Dental Material
3. Vitamin Pills
4. I.U.D (copper)
5. Birth Control Pills
6. ? ??? ???? ? ????????? ????? ? ???? ????? ????? ?
   ?????? ?????? ????? ??????.

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Copper Toxicity

• Symptomes
• ????? ?????? ??? ???? ?? ?? ?? ???? ?? ?????
  ?????? ??? ??????? ??
• ???? ???? ?????? ????? ????? ??????? ?????? ?
  ??????? ???? ?? ?? ??? ????? wilson syndrom ??
  ?????

• ??? ????? ?? ?? ???? ?? ??? ???? ????? ??????
  ?????? ?????? ? ????? ?????? ??????? ?? ???? ???
  ????????? ?????? ???? ? ??????? B6 ??????? ????.

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???? Mercury
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???? ??? ?? ??? ???? ????? ?????? ??? ?? ????

• ??? ??? ?? ???? ????? ????????? ??? ???? ?????
  ???? ? ?????????? ?? ??? ????? ??? ??? .

• ???? ?? ??? ?? ? ????? ?????? ? ????????? ?????
  ? ?? ????? ??? ????????????????? ? ??? ????? ???
  ????? ? ??????? ? ????????? ????? ? ?????? ?
  ????? ? ?????? ?????? ? ????? ???.
• ??? ?? ????? ??? ?? ???? ??? ?? ????? ?? ???? ??
  ????.

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???? ???? 50 Dental filling ?? ????? ?????
????????? ?? ?????? ??? tin mercury copper
silver ???? ????.
?? ????? ????? ??? ?????? ?? ????? ?? ??? .
?? ?? ??? ????? ???? Dental Amalgam ?? ?????
?? ????? ???? Mercury Poisoning Amalgam
illness
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????? ??????? ???? ???????? ?????????? ?? ????
??? ?? ????????? ?? ???? ????????? ????? ??????
??? ? ?????? ?????? ???? ????? ???????? ????? ???
??????? ?? ????? ???? ???? ??? ????? ???? ?? ????
???? ???? ??? ???? ??? ???????? ??? ?????????
????.?? ??? ?? ??????? ???? ??? ??? ???? ?????
?? ???????? ?? ?? ????? ??? ???? ?? ???? ?????
??????? ???? ??? ???? ?????? ???? ??? MS,
Epilepsy ? ????? ??? ???
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Aluminium
Symbol Al
Atomic Number 13
Atomic weight 16.98154u
Color Silver
Electron configuration Ne3s23p1
Artificial knee joint
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• ?????????
• ?? ???? ?????????? - ???? ?????????? - ???????
  ??????????? ???? ?????? (????? ?? ???? ????)
  ????????? ? ?????????? ? ????? ???????? ????????
  ????? ? ????????? ? ??? ???? ? ??? ?????? ? ???
  ????? ? ?????? ???? ? ???? ????? ????? ??????.

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???? ??? ????????? ????? ?? ????? ?????
?????????? ?? ????? ???? ??? ????????? ?????
????? ???? ? ????? ? ???? ?????? ???? ?? ???? ?
??????? ? ?????? ?? ????? ?????
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• ???? ??? ??? ????? ??????? ??? ????? ?? ???????
  ? ??????? ?? Al ???? ???? ??? ?? ?? ????? ??? ??
  ??? ????? ????? ?? ??????? ???? 4 ????? ???????
  ????? Al ????? ?? ????? ???? ???? ??? ????? ?? ??
  ?? ??????? ???? ????? ???? ???.

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Cadmium
Symbol Cd
Atomic Number 48
Atomic weight 112.41u
Color Silvery
Electron configuration Kr4d10s2
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??????? ????? ?? 3 ??? ??? ? ?? ? ??? (??? ?????)
???? ??? ????? ?????? ???? ?? ?? ??????? ???? ???
??? ??????? ????? ?? ?? ????.

• ??????? ?? ?? ??? ??????? ??? ?????? ????
• 1- ??????? ?? ???? ?????? ?????? DNA
• 2- ???? ???? ????? ??? ???? DNA?? ?????????
  ??????? ??????? ???? ????

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????? ?? ????????? ??? ????? ???? ?? ???????
?? ???? ??? ???? ??????? ????? ?? ?????? ??
????? ????? ?? ??? ????? ?? ????????? ???????
?????? ??? ????? ?????? ??????? ???? ????
?????????? ??????? ??? ?????? ??? ? ???? ? ????
??? ????????? ?? ???? ??? ?????? ? ?????? ? ????
???? ???????????? 2 ????? ????? ???? ??? ??? ??
??????? ?????? ??? ?????? ????? ???? ???? 2 ?????
?????? ???? ? ???? ??????? ? ????? ????? ??? ?
?????? ???? ?????? ????? ??? ???? ?? ?????
?????.
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Chromium
Symbol Cr
Atomic Number 24
Atomic weight 51.996u
Color Gray
Electron configuration Ar3d54s1
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• ??????? ??? ?? ????? ??? ????? ?? ???? ??
  ????????? ???????? ???? ?? ???? ???? ?? ???.
• ?? ?????? ????? ???? ?? ?? ??? ???? ???
  ?????? ????? ?? ??? ??? ?????? ??? ????? ????
  ???? ???? ?? ?? ????? ???? .
• ??? ?? ?????? ??? ?????? ??????? ?? ?????
  ??????? ???? ???????? ?? ????.
• ???? ??? ???? ?? ?????? HDLP ?? ????

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• ???
• ?? ????? ????? ? ???????? ? ?? ???? ??? ???? ????
  ? ?????? ?????? ???????? ???????? ????? ??? ????
  ??? ????? ???? ?? ?? ? ???? ???? ????? ???? ????
  ? ????? ?? ? ????? ? ?? ???? ? ?? ??? ? ????
  ????.

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• GENERAL TREATMENT
• ??? ?? ?????? ??????? ????? ????? ?? ??? ???????
  ?? ???? ??? ?? ???? ?????? . ???? ??? ?? ???? ??
  ? ????? ?? ??? ???? ????? ???? ?? ????? ????
  ????? ??? ??? ?? ????? ???? ? ?? ???? ??? ??????
  . ???? ????? ? ????? ?????? ? ?????? ?????? ????
  ????? ? ?????? ? ??? ? ???? ? ????? ? ???????
  ???? ????? ????? ????? ? ??? ???? ??? ?? ????
  ???? ????? ???? ??????. ?????? ???? ????? ? ???
  ??? ?? ????? ?? ????? ????? ?? ??? ??? ? ???? ??
  ??????? ??? ???? ???????.

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Treatment Toxic Concentration Chronic Acute Metal
Proteinuria and/or15µg/g creatinine Proteinuria,lung cancer, osteomalacia Pneumonitis oxidefumes Cadmium
NAC (experimental) No clear reference standard Pulmonaryfibrosis lung cancer (inhalation) GIhemorhage hemolysis, acute renal failure Cr6 ingestion Chromium
NACCaNa2 EDTA Normal excretion0.1-1.2 µg/L serum0.1-2.2 µg/L urine Pneumoconiosis (inhaled) goiter Beer drinkers (dilated) cardiomyopathy Cobalt
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BAL D-PenicillamineSuccimer Normal excretion 25µg/24h (urine) Vineyard sprayers lung(inhaled)Wilson disease(hepaticandbasalgangliadegeneration) Blue vomitus, GI irritation/hemorrhage hemolysis,MODS (ingested)MFF inhaled Copper
Deferoxamine Nontoxic lt300µg/dLSeveregt500 µg/dL Hepatic cirrhosis Vomiting, GI hemorrhage, cardiac depression, metabolic acidosis Iron
BALSuccimer DMPS Europe Background exposure "normal" limits10 µg/L(whole blood)20 µg/L 24-h urine Nausea,metallic taste, gingivo-stomatitis, tremor,neurasthenia, nephrotic syndrome hypersensitivity(Pink disease) Elemental(inhaled)fever, vomiting,diarrhea, ALIInorganic salts (ingestion)caustic gastroenteritis Mercury
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Excessive exposure8µg/L blood Severepoisoning 500µg/L(8-h urine) Occupational (inhaled) pulmonaryfibrosis, reduced sperm count,nasopharyngeal tumors Dermatitis nickelcarbonyl myocarditis,AL, encephalopathy Nickel
Seleniu, vitaminE (experimental) Asymptomatic workers have mean Ag of 11µg/L(serum)and2.6µg/L (spot urine) Argyria blue-grey discoloration of skin,nails, mucosae Veryhighdoses hemorrhage,bone marrow suppression,pulmonary edema,hepatorenal necrosis Silver
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MDACPrussian blue Toxicgt3µg/L (blood) Late findings Alopecia,Mees lines,residual neurologic symptoms EarlyVomiting, diarrhea,painful neuropathy,coma,autonomic instability,MODS Thallium
Normal range0.6-1.1 mg/L (plasma)10-14 mg/L (red cells) Copperdeficiencyanemia,neurologic degeneration, osteoporosis MFF(oxide fumes) vomiting,diarrhea,abdominal pain (ingestion) Zinc