PHOTOACOUSTIC PROBE FOR TUMOR DETECTION - PowerPoint PPT Presentation

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PHOTOACOUSTIC PROBE FOR TUMOR DETECTION

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PHOTOACOUSTIC PROBE FOR TUMOR DETECTION HAIFENG WANG SUBHASHINI PAKALAPATI VU TRAN Department of Electrical and Computer Engineering University of Massachusetts Lowell – PowerPoint PPT presentation

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Title: PHOTOACOUSTIC PROBE FOR TUMOR DETECTION


1
PHOTOACOUSTIC PROBE FOR TUMOR DETECTION
  • HAIFENG WANG
  • SUBHASHINI PAKALAPATI
  • VU TRAN
  • Department of Electrical and Computer Engineering
  • University of Massachusetts Lowell

2
OUTLINE
  • Introduction
  • Principle of Ultrasound
  • What is Photoacoustic (PA)
  • Fiber-optic Source and Receiver
  • System of PA
  • How to fabricate
  • How PA system can detect tumor
  • Advantages and Disadvantages
  • Timeline
  • Tasks
  • Reference

3
INTRODUCTION
  • Cancer killed 570 000 people in 2010 in the USA.
  • Lot of methods to detect/predict tumor US,
    x-ray, CT, MRI, PET, SPECT, etc.
  • Photoacoustic (PA) takes advantage of fiber optic
    and ultrasound to detect tumor

4
PRINCIPLE OF ULTRASOUND
  • Transducer emit ultrasound wave and get signals
    back from object
  • D t.v
  • Scan volume to get image

5
WHAT IS PHOTOACOUSTIC?
  • Conversion of photons to acoustic wave due to
    absorption and localized thermal excitation.
  • Pulses of light is absorbed, energy will be
    radiated as heat.
  • Heat causes detectable sound waves due to
    pressure variation.

6
PHOTOACOUSTIC (Cont.)
7
DIAGRAM OF A TYPICAL PA SYSTEM
  • Themo-elastic Ultrsound Generation
  • Extrinsic fiber hydrophone, based on a
    Fabry-Perot interferometer

8
FIBER OPTIC ULTRASONIC SOURCE BASED ON
OPTO-ACOUSTIC CONVERSION
9
FIBER OPTIC ULTRASONIC RECEIVER BASED ON
ACOUSTO-OPTIC CONVERSION
10
TRANSMISSION STRUCTURE
  • 2D gold nanoparticle array sandwiched between a
    transparent substrate and a PDMS layer

11
GOLD NANOSTRUCTURE
The top view (a) and sketch of the side view( b)
of the gold nanostructure.
12
DETECTION OF TUMOR USING PAI
  • Tumors have dense and unorganized vasculature.
  • High density of blood vessels in tumors enhances
    PAI contrast.

13
DETECTION OF TUMOR (CONT.)
  • Endogenous PA contrast
  • Melanin
  • Oxy Hemoglobin
  • Deoxy Hemoglobin
  • Exogenous PA contrast (Highly sensitive to deeply
    situated tumors)
  • Au NP
  • Alexa Fluor
  • Indocyanine Green

14
ADVANTAGES
DISADVANTAGES
  • Ability to detect deeply situated tumor and its
    vasculature
  • Monitors angiogenesis
  • High resolution
  • Compatible to Ultra Sound
  • High Penetration depth

1. Limited Path length 2. Temperature Dependence 3
. Weak absorption at short wavelengths
15
TIMELINE
16
TASKS
  • HAIFENG WANG
  • Principle of Photoacoustic
  • Fabricate PA structure
  • SUBHASHINI PAKALAPATI
  • Principle and procedure of tumor detection using
    PA
  • AuNP enhanced
  • VU TRAN
  • Compare other methods to detect tumor
  • AuNP enhanced

17
REFERENCES
  • 1 Jemal,A. et al. Cancer Statistics, 2010. CA
    CancerJ.Clin. 60, 277300
  • 2 Hou, Y., et al., Optical generation of high
    frequency ultrasound using two-dimensional gold
    nanostructure. Applied Physics Letters, 2006.
    89(9) p. 093901-3.
  • 3 Mallidi, S., G.P. Luke, and S. Emelianov,
    Photoacoustic imaging in cancer detection,
    diagnosis, and treatment guidance. Trends
    Biotechnol, 2011.
  • 4 Tang, M.X., et al., Photoacoustics,
    thermoacoustics, and acousto-optics for
    biomedical imaging. Proc Inst Mech Eng H, 2010.
    224(2) p. 291-306.
  • 5 Wang, X., et al., Photoacoustic tomography a
    potential new tool for prostate cancer. Biomed
    Opt Express, 2011. 1(4) p. 1117-1126.

18
THANK YOU
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