Developments at the

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Developments at the Nano/Bio Interface Point to
Scientific Opportunities
Functional Molecules and Hybrid Nanostructures
Single Molecule Motion and Complexity
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Peptide Complexes Designed for Optoelectronic
Function
Blasie, DeGrado, Therien, Saven J. Am. Chem.
Soc. (2008)
Saven, DeGrado, Therien, J. Am. Chem. Soc. 2004
Saven, DeGrado, Therien, Blasie, J. Am. Chem.
Soc. 2007
Saven, DeGrado, Therien (2008)
Saven, DeGrado, Therien, (2008)
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Interface Mediated Behavior in Hybrid
Nanostructures
Functional Coxsackie virus-Adenovirus Receptor -
Nanotube Hybrid for Detection of Viral Protein
(Knob) Johnson and collaborators, Nano Letters
2007 J. Phys. Chem. B 2009
Plasmon Induced Electronic Transport in
Functionalized Nanoparticles Bannerjee et al in
press
NanoLetters 08
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Ferroelectric Nanolithography Extended to
Flexible Substrates
The ultimate goal is to assemble multiple
components of diverse properties into complex
configurations. Ferroelectric Nanolithography
achieves this by controlling local electronic
structure on substrates that influences
electron transfer at the surface.
Rankin, et al ACS Nano 2008
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Primary and coupled surface plasmons
Absorption in the porphyrin
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Plasmon Induced Electronic Transport in
Molecules
Bannerjee, et al in press
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Plasmonics Molecular Electronics SERS
single molecule properties light
guiding switching control optical properties
of organics sensing meta materials targeted
therapeutics
Mark Reeds Group
Harry Atwater, Nature Materials 2003
http//www.eng.yale.edu/reedlab/
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New mechanism for transduction of optical energy
to electrical energy
Optical antenna effect focuses light to the
nanoparticle junction increasing absorption
efficiency, enhancement can be factors of 105 or
more. Absorption wavelengths/energies can be
tuned by choice or design of the molecule and
morphological control of nanoparticle array

Ghosh, S.K. and T. Pal,. Chemical Reviews, 2007.
107(11) p. 4797-4862
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Protein Motion at the Single Molecule Level
Myosin V Processivity
Science 2005, 2007
Goldman Group
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Protein Motion at the Single Molecule Level
Myosin V Processivity
Science 2005, 2007
Goldman Group
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Protein Motion at the Single Molecule Level
Myosin V Processivity
Science 2005, 2007
Goldman Group
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Protein Motion at the Single Molecule Level
Myosin V Processivity
Science 2005, 2007
Goldman Group
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Protein Motion at the Single Molecule Level
Myosin V Processivity
Science 2005, 2007
Goldman Group
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Complexity of the Cytoplasm and Cytoskeleton
Grn mtubules Red actin
Medalia et al. 2002 Science. 2981209-13.
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Unhindered Motion of Myosin Motors
Goldman, Bau, Arsenaut
Arsenault, M., Zhao, H., H., Purohit, P.,
Goldman, Y., and Bau, H. H., 2007, Biophysical
Journal 93, L42-L44
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Increased Complexity in Protein Environment
Goldman, Bau, Shuman Science 2008 J. Biophysics
2009,
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Whole Lotta Shakin
We have exquisite information about the static
structures of cellular components, but still
little understanding of how they orchestrate
their many dynamic functions. The understanding
now beginning to emerge will influence cell
biology over the coming years.
Drosophila S2 cell with microtubules shown in red
and peroxisomes in green.
Recently developed imaging technology allows us
to look inside living cells with unprecedented
spatial and time resolution (nanometers and
milliseconds). Extending this method to two
colors allowed us to perceive previously hidden
relations between cell components. For example,
our work documented correlation between the
motions of distant call cargos, indicating that
they were both attached to the same active
structural element (a microtubule).
IM Kulic and PC Nelson, Europhys Lett 2007 IM
Kulic, AEX Brown, H Kim, C Kural, B Blehm, PR
Selvin, PC Nelson and VI Gelfand, The role of
microtubule movement in bidirectional organelle
transport. PNAS 2008.
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Scientific Opportunities
Biomolecule platforms and Hybrid nanostructures
offer pathways to engineered function pathogen
detection protein sensors optoelectronic
devices energy harvesting strategies Single
molecule studies in the context of realistic
environments reveal complex behavior cell
division (cancer) disease targets cell motion
disease targets live proteomics in situ protein
synthesis Probes of nanoscale phenomena are
poised for another revolution