Treatment of Anemia

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Treatment of Anemia
Disease Treatment
Fe deficiency anemia Ferrous sulfate and ferrous gluconate
Thalassimia Desferoxamine ( increases iron secretion from the body to prevent toxicity by hemocydersosis (accumulation of iron in tissue)
Megaloblastic anemia Vitamin B 12 and folic acid
Anemia of chronic diseases Heamopiotic growth factor ( erythropoietin)
Neutopenia FligraSTIM, lenograSTIM, MolgraSTIM that will increase neutophils and monocyte production
Polycytaemia Vera Young patients chemotherapy Elderly Radiophosphorous
Aplastic anemia Bone marrow transplantation Heamopiotic growth factor
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Vitamin K analogues
Menodiol Sodium phosphate Synthetic water soluble
Vitamin-K
Phytomenadione Naturally occuring Vitamin-K fat
soluble
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Anticoagulants
Type Direct Indirect
example heparin Courimen (warfarin)
Action Inhibit thrombin and coagulation factors Inhibits vitamin K epixoide
Onset of action Immediate After 3 days
Route of administration Parental Oral
Cross the placenta NO yes
Monitor its action by PTT PT
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Antiplatelets

• Dipyradimole
• Phosphodiesterase inhibitor
• cAMP
• platelets aggregation

• Aspirin
• cyclo-oxygenase
• Thromboxine A
• Platelets aggregation

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Fibronytic Drugs Are all Plasmonogin activators
1st generation Ex. Steptokinase Urokinase Not
specific for fibrinogen ? Systemic Firbonlysis

• 2nd generation
• Ex. Tissue plasmonogin activator
• Specific for fibrinogen
• Less systemic firbronlysis

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Antifibrinlytic drugs ( ? Plasminogen binding to
firbirn) by inhibiting lysin interaction
Amino-capronic acid
Tranexamic acid
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HIV Treatment
Reverse transcriptase inhibitors
Protease inhibitors -NAVIR Side effects ?Sugar
?Lipid ?LFT Bleeding
Non Nucleoside-RTI VIR. Side effect Rash
Nucleoside-RTI Purines (beginning of
alphabetic) Pyramidines (end of alphabetic)
Nucleotide- RTI Tenovir
HIV treatment we use combination of drugs that
have different structure and different side
effects