Most new proteins come from genome sequencing projects

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Most new proteins come from genome sequencing
projects

• Mycoplasma genitalium - 484 proteins
• Escherichia coli - 4,288 proteins
• S. cerevisiae (yeast) - 5,932 proteins
• C. elegans (worm) 19,000 proteins
• Homo sapiens 40,000 proteins

... and have unknown functions
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Bioinformatics and Genomics/Proteomics
Unknown Genes
3
The changing face of protein science

• 20th century
• Few well-studied proteins
• Mostly globular with enzymatic activity
• Biased protein set

• 21st century
• Many hypothetical proteins
• Various, often with no enzymatic activity
• Natural protein set

4
FBB
Bioinformatics strategy
GENETICS
EVOLUTIONARY BIOLOGY
COMPUTATIONAL BIOLOGY
FUNCTIONAL GENETICS
PROTEOMICS
STRUCTURAL GENIMOCS
Bioinformatics
METABOLOMICS
GENOM SEQUENCING
PROTEIN INTERACTION NETWORKS
LITERATURE
CLINICAL DATA
5
Modern biotechnology

• MARKET - 500 billions US
• Europe - 1570 companies
• USA - 1273 companies

• Human genome - 1988
• 3 billions US
• More than 30 countries
• Bioinformnetworks
• Genomics
• Proteomics
• Metabolomics

• Health
• Agriculture
• Environmental
• Energy
• Industry
• Bioinformatics

in vitro in vivo
INSILICO
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From Genomics to Products
Markers
New Genes
B i o i n f o r m a t i c s
New Trails
Transcriptome
Proteome
Metabolome
New Actions
Genomics Platform
Profiling
New Products
7
Algorithmic developments

• Important part of research in bioinformatics
• methods for
• data storage
• data retrieval
• data analysis

8
HTML

• the hypertext markup language used on the World
  Wide Web (WWW)
• plain-text (ASCII) files created any text editor
  (e.g., Notepad) or WYSIWYG (What You See Is What
  You Get) editors (HotMetal, Microsoft Front Page
  Editor\ Netscape Editor).

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An element

• a fundamental component of the structure of a
  text document/
• heads, tables, paragraphs, and lists
• Tags used to mark the elements
• HTML tags
• a left angle bracket (lt)
• a tag name
• a right angle bracket (gt).
• Tags are usually paired (e.g., ltH1gt and lt/H1gt) to
  start and end the tag instruction.
• HTML not case sensitive.lttitlegtltTITLEgtltTiTlEgt

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Simple HTML file

• HTML tell browser the file contains HTML-coded
  information.
• HEAD the first part of your HTML-coded document
  
• TITLE the document title. The title is
  displayed somewhere on the browser window
  (usually at the top). keep your titles to 64
  characters or fewer.
• AUTHOR This information can be helpful to
  readers who've found the document by using a Web
  search tool.
• DESCRIPTION A brief description. helpful to
  readers searching for a specific topic.
• KEYWORDS searching services use to help users
  locate the document on the Web.
• BODY The second--and largest--part of your HTML
  document is the body, which contains the content
  of your document
• Paragraphs Unlike documents in most word
  processors, carriage returns aren't significant.
• A Web browser ignores any empty line break and
  starts a new paragraph only when it encounters
  another ltPgt tag.

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Extra

• Physical Styles
• ltBgt bold text
• ltIgt italic text

• Linking in HTML
• Hypertext-related tag is ltAgt
• start with ltA (space after A)
• specify the linking document by HREFfilename
  followed by (gt)
• enter the text as the hypertext link
• enter the ending anchor tag lt/Agt (no space)
• ltA HREFMaineStats.htmlgtMainelt/Agt
• Maine the hyperlink to the document
  MaineStats.html.