UAMS CENTER FOR CLINICAL

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UAMS CENTER FOR CLINICAL TRANSLATIONAL RESEARCH
(CCTR) Center OverviewUNIVERSITY OF ARKANSAS
FOR MEDICAL SCIENCESuams.edu/cctr
Curtis L. Lowery, MDCCTR Director 501-686-5847
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Clinical and Translational Science Awards (CTSAs)

• Led by the National Center for Research Resources
  (NCRR) at the National Institutes of Health
  (NIH).
• Working as a national consortium, CTSA
  institutions share a common vision to improve
  human health by transforming the research and
  training environment.
• Team science partnerships-Collaboration-Connectivi
  ty-Breaking down institutional barriers

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T1 Translational Science

• Transfer of new understandings of disease
  mechanisms gained in the laboratory into the
  development of new methods for diagnosis,
  therapy, and prevention and their first testing
  in humans.
• Requirements mastery of molecular biology,
  genetics, and other basic sciences appropriately
  trained clinical scientists working in strong
  laboratories and with cutting-edge technology
  and a supportive infrastructure within the
  institution.

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T2 Translational Science

• Research in the community and ambulatory care
  settings
• Population based interventions and practice-based
  research networks bring
• Requirements mastery of the implementation
  science of developing and evaluating
  interventions in real world settings and of the
  disciplines such as clinical epidemiology and
  evidence synthesis, communication theory,
  behavioral science, public policy, financing,
  organizational theory, system redesign,
  informatics, and mixed methods/qualitative
  research.

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T1/T2 Summary

• T1- Bench (lab) science to subject testing
• Animals
• Test tubes
• Human subjects (controlled or lt 1,000)
• T2 Taking it to the streets
• Real world use by every day practitioners
• Population-based results
• Community involvement

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National CTSA Organizational Chart
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CTSA Consortium History

• Consortium launched in 2006 with additions each
  year
• 46 current member institutions (60 at full
  implementation)
• UAMS first applied in October 2007
• Score 196
• Second application in October 2008
• Score 147
• 7th best in the country

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Current CTSA Locations
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Consortium Committees

• Leadership Committees
• Steering PIs of each CTSA
• Child Health Oversight
• Strategic Goal Committees
• National Clinical and Translational Research
  Capability
• Training Career Development of
  Clinical/Translational Scientists
• Enhancing Consortium-Wide Collaborations
• Enhancing the Health of Our Communities
• T1 Translational Research

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Consortium Key Function Committees

• Administration
• Biostatistics/Epidemiology/Research Design
• Clinical Research Ethics
• Clinical Research Innovation
• Communications
• Community Engagement
• Education and Career Development
• Evaluation
• Informatics
• Public-Private Partnerships
• Translational

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UAMS CCTR Goal

• The CCTRs overarching goal is to transform the
  pace, effectiveness, and quality of translational
  research among UAMS and its partners, resulting
  in better health for all Arkansans.

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CCTR Location

• Currently Reynolds Institute on Aging
• Recovery Act Core Facility Renovation, Repair,
  and Improvement (G20)
• Renovate
• Central Building 4 B, C, and D
• Central Building ground floor Metabolic Kitchen
• Barton 3rd floor
• Includes
• CRC
• Informatics
• Administration
• Research Support Center
• Other

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Required Program Components-All CTSAs

• Regulatory Knowledge and Support
• Participant and Clinical Interaction Resources
• Research Design, Biostatistics, and Clinical
  Research Ethics
• Biomedical Informatics
• Research Education, Training, and Career
  Development
• Novel Methodologies Pilot and Collaborative
  Studies
• Translational Technologies and Resources
• Community Engagement

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Special Strength Program Components at UAMS

• Health Services Research
• Behavioral Research
• Epidemiology
• Plus
• Overall and Governance
• Tracking and Evaluation

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Overall and Governance

• Director
• Curtis Lowery, MD
• Co-Directors
• Cornelia Beck, PhD, RN, FAAN
• Lawrence Cornett, PhD
• Co-Investigators
• Warren Bickel, PhD
• Peter Emanuel, MD
• James Raczynski, PhD
• Elie Al-Chaer, PhD
• Aubrey Hough, MD

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Executive Steering Committee
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Regulatory Knowledge and Support

• Director
• Thomas G. Wells, MD
• Overall Goal
• To optimize performance of the support services
  for each step of a clinical trial in order to
  insure research subject safety and compliance
  with federal regulations.

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Regulatory Knowledge and Support

• Navigators
• Help researchers/staff navigate system and
  receive timely, appropriate support
• CRIMSON
• ARIA
• IRB
• Writing
• Portal Administrator
• Recruitment Specialist
• Assists in
• appropriate study design
• recruitment and retention of participants
• minority recruitment
• interfacing with recruiting outlets and
• website (portal) design.
• Assures
• ethical practices are used and
• recruiting rates are acceptable
• Works with the Minority Recruiting Center

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Novel Methodologies Pilot Studies

• Co-Directors
• S. Michael Owens, PhD
• Sudhir Shah, MD, FACP
• Overall Goal
• To create a UAMS research environment that
• focuses scientific and clinical researchers on
  applying innovative ideas and knowledge to
  benefit patients and communities
• brings new talent to clinical and translational
  sciences
• facilitates interdisciplinary research by
  population, clinical, and laboratory-based
  sciences to increase the pace of medical
  discovery
• identifies and manages barriers to bringing
  important discoveries to patients bedsides and
  the community.

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Rainmakers

• Forward thinking, proven scientists from a broad
  array of disciplines, departments, and colleges
  charged with fostering collaborative interactions
  and nurturing investigators in development of
  novel ideas
• S. Michael Owens, PhD, Co-director (COM,
  Pharmacology Toxicology)
• Sudhir V. Shah, MD, FACP, Co-director (COM,
  Nephrology)
• Mary Aitken, MD, MPH (COM, Pediatrics COPH)
• Cornelia Beck, PhD, RN (CON, COPH, COM)
• Warren Bickel, PhD, (COM, Psychiatry)
• Marie Chow, PhD (COM, Microbiology Physiology)
• Michael Douglas, PhD (UAMS BioVentures)
• Martin Hauer-Jensen, MD, PhD (COP, COM)

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Novel Methodologies Pilot Studies

• Awards for Innovative Clinical and Translational
  Research
• Funding
• 200,000 CTSA grant award
• 200,000 ACH
• 600,000 UAMS
• Investigator-Initiated Pilot Award (up to
  50,000/award)
• Collaborative Research Award (up to
  100,000/award)
• High Impact Award (up to 150,000/award)

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Biomedical Informatics

• Acting Director
• Alan VanBiervliet, PhD
• Associate Directors
• Thomas Kieber Emmons, PhD
• David Nelsen, MD
• Laura Hutchins, MD
• Overall Goal
• To develop, implement, and evaluate a biomedical
  knowledge grid accessible to CCTR investigators
  that will improve clinical and research
  integration and interoperability with data
  quality.

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Research Education, Training, and Career
Development

• Co-directors
• Robert McGehee, PhD
• Katharine Stewart, PhD, MPH
• Robert Safirstein, MD
• Overall Goal
• To transform existing loosely structured
  educational components at UAMS into training and
  career pathways for clinical and translational
  research professionals.

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Research Education, Training, and Career
Development

• Pathfinder Committee
• Key UAMS faculty members who are top leaders and
  among the most active researchers
• Ensure trainees consistently receive outstanding
  mentorship and guidance
• K12 Scholar-type program
• Mentored career development
• Post- MD, PhD, PharmD, DDS education and training
• Grant supports two trainees, UAMS supports up
  four additional trainees
• Award aims to increase T32, K, and F funding

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Translational Technologies and Resources

• Director
• Philip Mayeux, PhD
• Overall Goal
• Maintain high-quality, cost-efficient,
  state-of-the-art core facilities
• Regular review and periodic retooling to deliver
  state-of-the-art services in a reliable,
  cost-efficient manner.
• Assist in securing extramural and intramural
  funding for new technologies and new core
  facilities

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Community Engagement

• Director
• Paul Greene, PhD
• Associate Directors
• Mary Kathryn Stewart, MD, MPH
• Mark Mengel, MD, MPH
• Overall Goal
• To develop complementary service and research
  infrastructures for a translational research
  environment in which communities can examine,
  understand, and change factors contributing to
  chronic illness and health disparities.

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Design, Biostatistics, and Clinical Research
Ethics

• Director
• Paula Roberson, PhD
• Co-directors
• Chris Hackler, PhD
• D. Micah Hester, PhD
• Overall Goal
• To generate feasible, well-designed protocols
  which produce reliable data to be translated into
  communities to improve public health

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Epidemiology

• Co-directors
• Fred Kadlubar, PhD
• Martha Phillips, PhD
• Overall Goal
• To provide the expertise, techniques, and tools
  for state-of-the-art epidemiologic methods for
  clinical and translational research. The ultimate
  goal is to improve the health of all Arkansans.

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Health Services Research

• Co-directors
• Glen Mays, PhD, MPH
• Bradley Martin, PharmD, PhD
• Overall Goal
• Study social, behavioral, and epidemiologic
  research methods in order to study the
  organization, financing, and delivery of health
  care
• Create a forum for multiple stakeholders to share
  ideas and resources and work collaboratively

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Participant and Clinical Interaction Resources

• Director
• Peter Emanuel, MD
• Associate Program Director
• Aubrey Hough, MD
• Overall Goal
• To expand participation of UAMS faculty in
  clinical and translational research, leading to
  an environment of scholarship and inquiry for
  clinical and translational research.

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Behavioral Research

• Director
• Warren Bickel, PhD
• Overall Goal
• To provide the expertise, techniques, and tools
  for state-of-the-art behavioral science in
  clinical and translational research, with the
  ultimate goal of improving the health of all
  Arkansans.

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CCTR Component Program Managers

• Acts as administrative leader for each component
• Ensures projects involving multiple program
  components are integrated within the CCTR
• Communicates improved procedures to other
  components, needs for resources