Jeopardy!

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Jeopardy!
Immunology Edition! By Brian Jackson, MS I
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Instructions

1. Choose the category and dollar amount. The
   answer will appear on your screen.
2. Once youve answered, click anywhere for the
   correct question.
3. IMPORTANT Click on the correct question to
   return to the board!
4. When youre done with a section, click on the
   link at the bottom of the board to advance.

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IL Wind Be Sensitive Sharing is Caring Less than Ideal Ouch! That Hurt! Feeling Sick
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400 400 400 400 400 400
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800 800 800 800 800 800
1000 1000 1000 1000 1000 1000
Click Here to advance to Double Jeopardy
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• Click here to return to the board.

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Barely Tolerated Innate Talents Organs of the Body Develop Yourself Signal Received Diagnosis Immunity
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800 800 800 800 800 800
1200 1200 1200 1200 1200 1200
1600 1600 1600 1600 1600 1600
2000 2000 2000 2000 2000 2000
Click to advance to Final Jeopardy
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• Click here to return to the board.

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Final Jeopardy!

• Category Immunology People
• Make your wagers now. After you have made your
  wager, click anywhere to continue to the Final
  Jeopardy answer, which you will need to write
  down on your own paper.

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Final Jeopardy!

• Category Immunology People
• He gave his name to the attenuated live polio
  vaccine administered outside of the United
  States.
• (slide will advance automatically after 30
  seconds)

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Final Jeopardy

• The correct question is...
• (click anywhere to see)
• Who is Albert Sabin?

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• Thanks for playing!
• Let me know if you had problems with the program
  or if any of the questions/answers are wrong!
  Comments are always appreciated as well!
• E-mail brianjac_at_gwu.edu
• End Game By Clicking Here

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200 IL Wind

• This cytokine is secreted by APCs and promotes
  secretion of interferon gamma.
• What is IL-12?

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400 IL Wind

• This cytokine promotes immunoglobulin switching
  to IgE.
• What is IL-4?

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600 IL Wind

• This cytokine promotes eosinophil growth.
• What is IL-5?

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800 IL Wind

• These two cytokines are responsible for the acute
  phase inflammation response.
• What are IL-1 and IL-6?

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1000 IL Wind

• This molecule is expressed on stromal cells in
  the thymus and is required for proper T-Cell
  development.
• What is IL-7?

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200 Be Sensitive

• This type of hypersensitivity reaction is
  mediated by histamine, serotonin, heparin, and
  chemotactic factors.
• What is a Type I reaction?

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400 Be Sensitive

• The hypersensitivity reaction most associated
  with a delay of 24 to 72 hours.
• What is a Type IV reaction?

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600 Be Sensitive

• Serum sickness is an example of this type of
  hypersensitivity?
• What is a Type III hypersensitivity?

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800 Be Sensitive

• This is a Type II reaction by a fetus to maternal
  Rh antibody.
• What is erythroblastosis fetalis?

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1000 Be Sensitive

• This condition is a common sign of a Type I
  hypersensitivity, and is found when cells bind to
  ADCC via F-c receptors for IgG and IgE.
• What is eosinophilia?

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200 Sharing is Caring

• A positive crossmatch test indicates that this
  type of reaction to an allograft is likely.
• What is a hyperacute reaction?

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400 Sharing is Caring

• An acute rejection requires these two things.
• What are allospecific T-cells and a context of
  disease (or inflammation)?

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600 Sharing is Caring

• This is the most common cause of death among
  transplant patients in the first year after
  transplant.
• What are cardiovascular problems?

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800 Sharing is Caring

• Cyclosporine is this type of immunosuppressant.
• What is a calcineurin inhibitor?

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1000 Sharing is Caring

• This organ was the first successful allograft in
  humans.
• What is the kidney?

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200 Less Than Ideal

• The boy in the bubble had this type of immune
  deficiency.
• What is SCID (Severe Combined Immune Deficiency)?

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400 Less Than Ideal

• This is an isotype switch defect with an
  increased amount of IgM and a decreased amount of
  other Igs.
• What is X-Linked Hyper-IgM Syndrome?

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600 Less Than Ideal

• Most immunodeficiency diseases are of this
  general type.
• What are antibody deficencies?

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800 Less Than Ideal

• Examples of deects in this system include
  decreased microbicidal activities in phagocytes,
  defects in NK cells, and complement deficiencies.
• What is the innate immune system?

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1000 Less Than Ideal

• This autosomal recessive disorder involves CD18
  and results in chronic leukocytosis, defective
  wound healing, and recurrent bacterial and fungal
  infections.
• What is Leukocyte Adhesion Deficiency Type 1?

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200 Ouch! That Hurt!

• Alum is the only approves one of these in humans.
• What is an adjuvant?

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400 Ouch! That Hurt!

• MMR and Varicella zoster are both vaccines of
  this type.
• What are live, attenuated vaccines?

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600 Ouch! That Hurt!

• The IgA antibodies in breastmilk provide this
  type of immunity to an infant.
• What is passive immunity?

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800 Ouch! That Hurt!

• The Hepatitis B vaccine was the first to use this
  technology.
• What is recombinant DNA technology?

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1000 Ouch! That Hurt!

• The WHO hopes that this disease will be
  eliminated by vaccination by the year 2010.
• What is polio?

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200 Feeling Sick

• This type of pathogen can replicate using RNA or
  DNA.
• What is a virus?

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400 Feeling Sick

• An example of this type of pathogen is Candida
  albicans.
• What is a fungus?

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600 Feeling Sick

• This bacteria causes toxic shock and skin
  abscesses and evades the immune system by means
  of a superantigen.
• What is staphylococcus?

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800 Feeling Sick

• African Sleeping Sickness is caused by this
  protozoan.
• What is Trypanosome?

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1000 Feeling Sick

• These two main antigens in influenza determine
  the classification of the virus.
• What are hemagglutinin and neuraminidase?

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400 Barely Tolerated

• The name for sites where antigens are kept
  separate from most lymphocytes to prevent an
  immune response.
• What are immunologically privileged sites?

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800 Barely Tolerated

• This is the most important genetic factor
  involved in autoimmune disease pathogenesis.
• What is MHC type?

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1200 Barely Tolerated

• Autoimmune Polyendocrinopathy Candidiasis
  Ectodermal Dystrophy involves a genetic defect in
  this gene.
• What is the AIRE gene?

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1600 Barely Tolerated

• This molecule negatively regulates T cell
  activation, and mice without this molecule have a
  lethal autoimmune lymphoproliferative syndrome.
• What is CTLA-4?

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2000 Barely Tolerated

• Lymphocytes that persistently receive a primary
  stimulatory signal without a co-stimulatory
  signal are likely to end up in this inactive
  state.
• What is anergy?

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400 Innate Talents

• These two complement molecules are
  chemoattractants for additional lymphocytic
  infiltration.
• What are C3a and C5a?

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800 Innate Talents

• CD8CD4- T-cells are associated with this type of
  MHC Complex.
• What is MHC Class 1?

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1200 Innate Talents

• Toll like receptors are an example of receptors
  that bind these molecules.
• What are PAMPs
• (pathogen associated molecular patterns)?

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1600 Innate Talents

• C3b is this type of molecule that enhances
  phagocytosis.
• What is an opsin?

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2000 Innate Talents

• This enzyme is primarily responsible for the
  oxidative burst in macrophages.
• What is NADPH oxidase?

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400 Organs of the Body

• This immune system organ is made up of red pulp
  and white pulp.
• What is the spleen?

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800 Organs of the Body

• The two immune organs designated as primary.
• What are the bone marrow and the thymus?

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1200 Organs of the Body

• The T-Cell zone within the spleen that surrounds
  certain blood vessels.
• What is the periarteriole lymphoid sheath?

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1600 Organs of the Body

• This lymphatic vessel empties into the left
  subclavian vein or the left jugular vein.
• What is the thoracic duct?

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2000 Organs of the Body

• Areas of enhanced lymphocytic activity in the
  submucosa of the small intestine are called
  these.
• What are Peyers patches?

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400 Develop Yourself

• B cell development is completed in this organ.
• What is the bone marrow?

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800 Develop Yourself

• Most T-cell receptors are made up of these two
  chains.
• What are alpha and beta?

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1200 Develop Yourself

• Receptor editing (additional chain
  rearrangements) occurs in this type of cell only.
• What are B cells?

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1600 Develop Yourself

• Immediately prior to lineage commitment as CD4 or
  CD8 cells, T-cells are called this.
• What are double positive T cells?

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2000 Develop Yourself

• The principle that there is only one type of
  receptor per one lymphocyte is called this.
• What is allelic exclusion?

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400 Signal Received

• Found in pentamer form, this is the first type of
  immungloublin produced by B cells.
• What is IgM?

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800 Signal Received

• Cytotoxic T-cells use this three-lettered
  receptor and its ligand to kill infected cells.
• What is fas?

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1200 Signal Received

• The process of changing from producing IgM to
  producing other immunoglobulins is called this.
• What is isotype switching?

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1600 Signal Received

• Interferon gamma is most associated with this
  type of T cell.
• What is a Th1 cell?

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2000 Signal Received

• Cells with these two CD numbers regulate T cells
  by secreting IL-10 and TGF-beta.
• What are CD4/CD25?

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400 Diagnosis Immunity

• This ABO blood type is the universal donor?
• What is O?

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800 Diagnosis Immunity

• ThoGAM is this type of antibody against Rh
  antigen.
• What is IgG?

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1200 Diagnosis Immunity

• A direct Coombs test detects antibodies bound to
  this type of cell.
• What is a red blood cell/erythrocyte?

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1600 Diagnosis Immunity

• A type IV delayed hypersensitivity reaction is
  used in a skin test for this disease.
• What is Tuberculosis?

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2000 Diagnosis Immunity

• A vaccine for HPV may help to prevent this type
  of cancer.
• What is cervical cancer?

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• The End!