Chapter 5 Neoplasia

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Chapter 5 Neoplasia

• Su Min (??)

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CPC-CASE (N0A6-1)

• A 37 year old man found a dark brown lesion on
  the skin of his face, just in front of the ear.
  He ignored the lesion, even though it became
  larger and started to bleed. Then he began to
  develop many more spots on his face and neck. At
  this point, he went to the doctor who did a
  biopsy and gave him some treatment. However, he
  died 8 months later.

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(Left) The early skin lesion. (Center) The
appearance of the many lesions on his face and
neck. (Right) The cut surface of his liver at
autopsy.
(Offered by Prof.Orr)
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(Left) A cross section of a rib at autopsy.
(right) His heart at autopsy. ( Offered by
Prof.Orr)
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(Left) Histologic section of normal skin.
(Right) Histologic section of a skin lesion.
(Offered by Prof.Orr)
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What is your diagnosis? What features of
neoplastic disease are shown in these photographs?
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Major Objectives

• To master the concepts of
• 1. Atypia.
• 2. Tumor growth and spread, including dysplasia,
  carcinoma in situ, invasion and metastasis.
• 3. Differences between benign and malignant
  tumors, carcinoma and sarcoma.
• 4. Nomenclature and principles of classification.
• 5. Pathological and clinical features of common
  tumors.
• To understand the etiological factors and
  cellular mechanisms involved in tumor development.

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The Variety of Tumors on Appearance
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• Neoplasia is a common disease, especially
  malignant tumors which damaged human health
  severely
• The death of malignant tumors
• About 7,000,000 in the would
• About 1,000,000 in China

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• The death of cancer accounting for all deaths
• the first cause in Chinese city
• the second cause in Chinese countryside

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(No Transcript)
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• The ten commonest malignant tumors in Chinese
• Respiratory tract

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• The ten commonest malignant tumors in Chinese
• Gastrointestinal tract

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• The ten commonest malignant tumors in Chinese
• Female genital
• breast cancer
  ovary cancer

Offered by Prof.Song W.Wong
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• The ten commonest malignant tumors in Chinese

lymphomas
leukemia