Acetylcholine Receptor Binding Toxins

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Acetylcholine Receptor Binding Toxins
Bungarus multicinctus ?-bungarotoxin toxin
source
Link to BioQUEST Lesson
Hypothesis Similar functioning proteins that
bind the ACh receptors will have similar amino
acid sequences.
Naja naja a-cobra toxin source
Results Overlay a-cobra toxin a (Y),
?-bungarotoxin (B), Cobratoxin (G), Erabutoxin (O)
ACh Receptor
Phylogenetic Tree
Conclusion Four (4) toxins that affect ACh
receptors were found to be closely related
evolutionarily resulting in proteins that have
structural areas of similarity in their amino
acid sequences.
Associated Amino Acid Residue Sequences
a-bungarotoxin ?-bungarotoxin Cobratoxin Erabutoxi
n