POST-WEANING DIARRHEA Diagnosis,Treatment,And Prevention Dr.Nathan Winkelman

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POST-WEANING DIARRHEADiagnosis,Treatment,And
PreventionDr.Nathan Winkelman
2003.6. 9

• ??DF
• ? ? ?(018-419-4409)

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Nursery(??)

• Soybeem
• Post -weaning DiarrheaE.coli.k88.F18
• PRRS related nursed problems Strep suis
  ,Respiratory Diease,mortality(??)
• Hemophilus parsuis,Strep suis,occasionally
  Actinoballus suis(???,???,??)
• Emerging disease-Circovirus Type A

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???? ??? ??? ??? (PMWS) Postweaning
multisystemic wasting syndrome

• 9798? ?? ???? ?? ??
• - Porcine circovirus
• - ???????? ?????? ??? ?? ?? ?? ?? (515 ??)
• - ????? ?? ??? (????-??)
• - ???? ??
• - ?????? ??/??,??????,????
• PRRS? ?? ??? (?? ?? ??)
• 6?? ? ?? ?? ?? (????? ???)

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????? Hemopholus Parasuis

• ??? ????? ?? ???? ?? ??
• - ??? ?? PRDC 1? ???? ??
• 3? ??? ?????? ?? ??
• ????? 10? ??? ??? ??
• - ???? ??? ??
• - ???? ????/??????? ??
• PRRS? ????? ?? ?
• - ????? ???

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Enteric Pathogens in the Nursery

• E,coli
• Rotavirus
• TGE
• Salmonella typhimurium
• Coccidiosis
• Non-infectious
• Stress
• Nutritional

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High Performance Nursery

• Mortality lt 1.5
• Age 70days
• Weight 70-77lbs(31.5-34.65kg)
• ADG 1.05-1.15lbs(470-517g)
• F/E 1.4-1.7
• Feed Cost/ gain
• Feed Cost/Pig to 70

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Health technologies to reduce or Eliminate
Diease(??)

• Complate depopulation and repopulation
• Partial depopulation and repopulation
• Isowean Principle
• Test and Remove
• All in ,All out
• by site ,locus ,building, or room

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Diease Eliminated Through Isowean Principle

• Diease Maximun weaning age
• Strep suis ????? none
• PRRS
  none
• Hemophilus Parasuis lt 10days
• Mycoplasma lt14days
• APP
  lt14days
• Toxigenic Pasteutella Multocidalt14days
• Bodetella Bronchiseptica lt14days

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Diarrhea-nursery pigsPost-Weaning Enteric
Pathogens

• Agent (???) Comment
• E.coli-colibacillosis Very
  common
• E,coli -edema diease Uncommon
• E.coli -septicema(???) Emerging diease
• Salmonnella Septicema or
  Diarrhea
• Rotavirus Concurrent with
  e.coli(???????)
• TGE Edemic
  -very common
• 
  Epizootic-Winter
• coccidiosis more common with
  early weaning
• nutritional very
  common

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B-Hemolytic E. coli

• Diarrhea, Edema Diease and Septicemia in weaned
  pigs.

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USA WEANING AGE

• 16-18days

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Treatment Routes For Diease

• Injetable Antibiotics sentive to the pathogen are
  the most cost effective method of treatment
• Water medication is implement when 5-20of the
  population is clinically affected. Pigs continue
  to drink even when they are not
  eating(?????5-20?)
• Feed medication least effective methed of
  treatment

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Diarrhea TreatmentBased on Sensitive Test
Results

• Injectable
• Gentamaycin-Dos 6.6mg/kg bw for 2-3days
• Ceftifur(excene17)Naxcell-Dose1cc/10kg for3days
• Ampicillen-Dose2.3mg/kg
• Amicacin-Dose6.6mg/kg
• Spectinomycin-Dose 1cc/10kg B.I.D

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E.coli Water Medication

• Gentamation Sulfate- 0.5mg/lbday for 3day
• Trimethoprin(5mg per ml)and Sulfamethoxazole(40mg
  per ml)-2 pints per 128 gallon stock solution
• Neomycin 325 Power-22mg/kg for 7day
• Amoxicillin-Extra lable use
• Cephlexin-Extra lable use

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E.coli Treatment Feed Antibiotics

• Denegard/Aureomycin at 35g/ton Tialimulin and
  400g/ton Chlortetracline commonly used in start
  pellets.(???1?)
• Corbodox most popular for enteric diease ,however
  ASP-250 is broader sprectrum for both respiratory
  and enterics

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Hemolitic E.coli-Diagnosis

• Clinical sign????
• Diarrhea-3 days to 3week post-weaning
• Gaunt, Rough-haired(??,????)
• Moibidity-1-40(???)
• Motality-1-20(???)
• Ante-mortemRectal swabs-Culture,PCR

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Feed Antibiotic FDA approved for Bacterial
Enteritis(Salmonnella,E.coli)

• Antibiotic Approved level Withdrawal
• Chlortetracycline 100-200 0
• Oxitetracycline 50-100 0
• ASP 250g/ton 15days
• Virginiamycin 25g/ton 0
• Bacitracin 250g/ton 0

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Prevention

• Acidity and Chlorinate the water for 3-7days
  after arrival.
• 1.Citric acid 1-2 /128 gallons
• 2.ElectrolytesOrganic acids ,Glycine
• 3.Chlorinate- 2-3ppm Chlorine

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Optimum PH gut levels for pathogen growth

• E.coli 6-8
• Streptococci 6-7.6
• Salmonella 6-7.5
• Stapirococci 6.8-7.5
• Clostridia 6-7.5
• Pseudomonas 6.6-7.0
• If PH is 4.0there is no growth of the above
  pathogens Target is to get close PH 3.0 as
  Possible

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Nersery Management

• Attention to details to maximise weaning weights!
• Hot water wash
• Environment
• warm ,dry, and draft free
• integrated heater and fan controls
• waterers(10??1?)
• feeders

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Feeding Manganment in nersery

• Withhold feed for 6-12hour post weaning before
  feeding
• Comfort mat-feed 4-6 times per day
• Limit feed the first 2-5days

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Vaccines

• There are no effective commerical E,coli
  vaccinations available to control post weaning
  diarrhea
• Oral autogenous vaccines vaccines have shown
  promise

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Nutrition

• Use complex nursery diats with highly digestable
  feed ingredient(???????)??)
• Spray dried porcine plasma(??)
• Fresh Menhaden fish meal
• Skim milk(????)
• Synthetic amino acids
• Optimum vitamin levels

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Nutrition

• Diarrhea control
• add zinc oxide at 3,000ppm for 2 week time period
  between 15-25pounds
• Remove blood meal
• Reduce Iron
• Specific 4or 5 phase feeding burget programs

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Recommend Lysine Levels for Segregated Early
Weaned Pigs

• Diet Pig wt,kg Total,Lysine
  DigestibleLysine
• Sew 4.9 1.7-1.8 1.4-1.5
• Transition 4.9-6.8 1.5-1.6 1.25-1.35
• Phase2 6.8-11.4 1.35-1.45 1.10-1.20
• Phase3 11.4-22.7 1.25-1.35 1.05-1.15

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Nersery Performance

• age wt(ADG)
  F/E
• 1988-Top10 63days 47 lb(0.8) 1.8
• 1999-Top10 63days 63 lb (1.1) 1.5
• 1999 Best Herd 63days 72 ld((1.5) ---

1999?BEST HERD 32.4KG
99 28.35KG
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ILEITIS

• ???(??)
• ?????-??? ??
• ??? ? ??
• ????(??? ??? ?? ??)
• ????
• ????? ??

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ILEITIS

• ?? ??? ?? ??
• Aereomycin 100g/ton 21? ??
• cabadox 25g/ton 42? 42?
• Linco 40g/ton 21? ??

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• ??? 3-4?? ??? ??
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