CAREERS IN THE PHARMACEUTICAL MANUFACTURING INDUSTRY - PowerPoint PPT Presentation

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CAREERS IN THE PHARMACEUTICAL MANUFACTURING INDUSTRY

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CAREERS IN THE PHARMACEUTICAL MANUFACTURING INDUSTRY HIGHER EDUCATION CAREERS ADVISOR CONFERENCE Monday 11 July 2005 Stuart Young, GlaxoSmithKline, – PowerPoint PPT presentation

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Title: CAREERS IN THE PHARMACEUTICAL MANUFACTURING INDUSTRY


1
CAREERS IN THE PHARMACEUTICAL MANUFACTURING
INDUSTRY
  • HIGHER EDUCATION CAREERS ADVISOR CONFERENCE
  • Monday 11 July 2005
  • Stuart Young, GlaxoSmithKline,

2
INTRODUCTION
  • Pharmaceutical manufacturing structure
  • Careers start point
  • Skills and competencies
  • Career development

3
Pharmaceutical Manufacturing
  • Primary
  • Manufacture of active ingredient
  • Typical site size workforce 200 -600
  • Scale kgs to tonnes per annum products
  • Majority of chemists biochemists recruited
  • Secondary
  • Formulation of drug delivery eg tablets,
    ointments, creams etc
  • Packaging etc
  • Workforce can be up to several thousand
  • Majority of pharmaceutical scientists recruited
  • Corporate
  • Manufacturing strategy
  • Demand forecasts etc
  • Central technical support

4
Dartford Site
5
Dartford Site
6
Primary Manufacturing - Challenges
  • Multi national
  • eg GSK sites in England, Scotland, Ireland,
    Singapore
  • Tax benefits
  • EU and Singapore doesnt favour UK
  • Low cost suppliers
  • eg India and China providing cost challenge to
    manufacturing in UK
  • Regulatory
  • Quality all important
  • eg FDA require much more demonstration of control
    on processes
  • Environmental controls becoming more stringent
  • IMPACT ON PRIMARY IN UK
  • Need to maintain and improve quality, cost
    effectiveness and compliance
  • Demonstrated quality standards are an advantage
  • Increase in technology eg automation
  • Technical knowledge needs to be maintained and
    increased

7
Chemists Start Point on a Primary Site
  • Functions
  • Technical
  • Production
  • Quality
  • Technical
  • Typically 5 -10 of site numbers
  • Chemists, Process Engineers and Analysts
  • Laboratory based
  • Production
  • Plant based
  • Day to day running of the plant
  • Quality
  • Analytical testing
  • Analytical test method development
  • eg measuring impurities at 0.01 level and in
    some instances lower

8
Dartford Site
9
Responsibilities
  • Process troubleshooting
  • Chemistry or manufacturing plant does not always
    run smoothly!
  • Can be expensive eg a batch could be valued at eg
    250k and operated several hundred times a year
  • In every function need to understand detail of
    the process, plant or analytical method
  • Continuous improvement
  • Need to provide developments to ensure quality
    and cost effectiveness
  • Identify technology which will have an advantage
    to processes
  • New product introduction
  • Life blood for any pharmaceutical manufacturing
    site
  • Ensure that the process, plant or analytical
    method provides product that is fit for purpose
    and is reproducible
  • Can demonstrate this to regulatory authorities
    either by submissions or during site inspections

10
Skills Competencies
  • Organic chemists
  • Dont need to be top class synthetic chemists!
  • Physical organic chemists
  • Increasing demand for understanding of physical
    properties of active ingredients and their
    performance in secondary formulations
  • Analytical scientists
  • Understanding of
  • Kinetics
  • Statistics
  • Technologies for monitoring processes

11
Skills Competencies
  • Attention to detail
  • Need to understand every detail of a process
  • Ability to work in a highly regulated industry
  • Accept that documentation is important!
  • Pace of change can be slow
  • Innovative!
  • Need to come up with ideas and press on to
    completion
  • Communication at all levels
  • Process operators
  • Factory Site Directors
  • Regulatory bodies eg FDA, HSE
  • Process Engineers
  • Research Development
  • Technologically competent
  • Be able to introduce new technology
  • Computer literate

12
Career Development
  • Technical expertise
  • Higher managers in manufacturing can start via
    the technical route
  • Site Directors tend to be chemists or process
    engineers
  • Opportunity to develop understanding of the
    business
  • Can take business studies courses as part of role
  • Technical background plus business understanding
    can lead to other functions
  • Procurement
  • Regulatory affairs
  • Production management
  • International opportunities
  • Transfer to other sites
  • Technical activities with third party
    manufacturers
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