Integrative Biophysics and Pulsed Electromagnetic Field Therapy

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Integrative Biophysics and Pulsed
Electromagnetic Field Therapy

• Keith R. Holden, M.D.
• Resonance Center
• Jacksonville Beach, FL
• www.ResonanceCenterJax.com

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Outline

• Integrative Biophysics.
• Pulsed Electromagnetic Field (PEMF) Therapy as an
  instrument of integrative biophysics.
• Biomolecular effects.
• Epigenetic effects.
• Cellular physiologic effects.

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Outline cont.

• Optimal tissue frequencies.
• Proof of efficacy via peer reviewed studies,
  including RDBPC clinical trials.
• Ondamed as a powerful instrument of integrative
  biophysics.

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Integrative Biophysics

• Holistic integration of quantum energetic,
  molecular, biochemical, and physiologic processes.

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Integrative Biophysics

• Reflects the web-like interconnectedness of all
  biologic systems within the body and that of the
  body with its environment.

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Integrative Biophysics

• Honors energetic and biochemical individuality.

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Integrative Biophysics

• PEMF instrument for integrative biophysics.

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PEMF Biomolecular Effects

• Larmor Precession Model
• External pulsed electromagnetic field matches the
  (Larmor) spin frequency of hydrogen atom causing
  energized electrons to emit a photon, which act
  as a vital energy carrier for tissue repair.
• Ion/ligand binding at cell membrane.
• Alters cascade of biological processes for tissue
  growth and repair.

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PEMF Biomolecular Effects

• Amplification of the tissue repair field (current
  of injury).

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PEMF Epigenetic Effects

• Upregulation of genes involved in normal cell
  growth.
• (Goodwin, 2003)

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PEMF Cellular Effects

• Increases osteoblast intracellular calcium
  alters response to epidermal growth factor.
• (Shigaku,1990)
• Stimulates production of type-I collagen,
  osteocalcin, osteopontin.
• (Cornaglia, et al., 2006)
• Antiinflammatory effect via restoration of plasma
  membrane calcium ATPase activity.
• (Selvam, et al., 2007)

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Frequencies for Tissues

• Nerve-2 Hz
• Bone-75 Hz
• Ligament-10 Hz
• Capillaries and skin-15 Hz
• (Sisken, et al., 1995)
• (Shupak, 2003)

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Frequencies for Conditions

• Fracture non-union 65-75Hz
• Congenital pseudoarthrosis 15Hz
• Osteoporosis 72Hz
• Hip arthroplasty 50Hz
• Arthritis 50Hz
• Tinnitus 0.5-17Hz
• Rotator Cuff Tendonitis 71-75Hz
• Venous skin ulcers 75Hz
• Multiple sclerosis 4-13Hz
• (Shupak, 2003)

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Clinical Trials

• Randomized, Double Blind,
• Placebo Controlled

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Chronic Lower Back Pain

• Randomized double blind placebo controlled
  (RDBPC) clinical trial.
• PEMF 3X a week for 3 weeks for chronic lower back
  pain.
• Significant reduction in pain and disability over
  placebo.
• (Lee, 2006)

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Musculoskeletal Chronic Pain

• RDBPC clinical trial.
• Chronic generalized pain from fibromyalgia or
  chronic localized musculoskeletal pain.
• PEMF twice daily 40 min. for 7 days.
• PEMF effect over sham for fibromyalgia approached
  statistical significance.
• (Thomas, et al., 2007)

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Cervical Osteoarthritis

• RDBPC clinical trial.
• PEMF 30 min. 2X a day for 3 weeks.
• Neck pain, PVMS, and disability scale scores
  decreased, and AROM increased significantly in
  the PEMF group.
• No change in the sham group.
• (Sutbeyaz, et al., 2006)

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OA of knee and cervical spine

• RDBPC clinical trial.
• 86 patients with OA of knee.
• 81 patients with OA of cervical spine.
• Statistically significant improvement in treated
  patients for pain and ADLs at end of treatment
  and at one month follow up.
• (Trock, et al.,1994)

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Lateral epicondylitis

• RDBPC clinical trial.
• Group I (PEMF), Group II (sham PEMF), Group III
  (corticosteroid anesthestic inj.)
• Group III had lower pain than Group I and Group
  II at third week.
• Group I (PEMF) patients had lower pain than
  Groups II and III at third month.
• (Uzunca, et al., 2007)

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ACL reconstruction

• RDBPC clinical trial.
• Preclinical studies show that PEMF limits
  catabolic effects of pro-inflammatory cytokines
  on articular cartilage.
• PEMF 75 Hz 4 hours per day for 60 days.
• Functional recovery occurs earlier with PEMF
  group.
• (Benazzo, et al., 2008)

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Fibromyalgia

• RDBPC clinical trial.
• PEMF 30 min. twice a day for 3 weeks.
• At 12 weeks follow up, PEMF group showed
  significant improvements in pain compared to sham
  PEMF.
• (Sutbeyaz, et al., 2009)

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Arthroscopic knee surgery

• RDBPC clinical trial.
• PEMF for 90 days 6 hours per day.
• PEMF group statistically significant improvement
  at 90 days.
• NSAID use PEMF (26) sham (75).
• 3 year follow up, number of patients who
  completely recovered was higher in PEMF.
• (Zorzi, et al., 2007)

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Multiple Sclerosis

• RDBPC clinical trial.
• PEMF 4 weeks.
• Assessed MSQLI- fatigue, bladder control,
  spasticity, QOL composite.
• Statistically significant improvement in fatigue
  QOL none bladder control mixed spasticity.
• (Lappin, et al., 2003)

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OA knee

• RDBPC clinical trial.
• PEMF 84 sessions for 30 min.
• WOMAC index dec. 84.1 to 49.7 in PEMF and 73.7 to
  66.9 in sham.
• Secondary parameters improved over sham gait
  speed, stride length, acceleration time.
• (Nicolakis, et al., 2002)

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Interbody lumbar fusions

• RDBPC clinical trial.
• Active group 92 success rate.
• Sham group 65 success rate.
• (Mooney, 1990)

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Rotator cuff tendinitis

• RDBPC clinical trial.
• Refractory rotator cuff tendinitis.
• PEMF showed significant improvement over sham
  during the first four weeks.
• No significant difference between groups when
  both received PEMF.
• End of study 65 were asymptomatic.
• (Binder, 1984)

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Conditions amenable to PEMF
CONDITION FDA APPROVED SUCCESS RATE
Fracture nonunion Yes 75-95
Failed joint fusions Yes 85-90
Spinal fusions Yes 90-95
Congenital pseudoarthrosis Yes 70-80
Osteonecrosis (hip) No 80-100
Osteochondritis dessicans No 85-90
Osteoporosis No 85-90
Chronic tendinitis No 85-90
Chronic skin ulcers No 85-90
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PEMF Impact on Cell Physiology

• Bassett, CA, Beneficial Effects of
  Electromagnetic Fields. J of Cell Biochemistry.
  1993 51387-393.

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Fracture nonuinon, failed joint fusion,
congenital pseudoarthrosis

• T mineralization
• T angiogenesis
• T collagen GAG production
• Endochondral ossification
• (T osteoclasis for pseudoarthrosis)

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Spinal fusion, osteonecrosis, and osteoporosis

• T angiogenesis
• T osteoblastic activity

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Chronic tendinitis andchronic skin ulcers

• T angiogenesis
• T collagen GAG production

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Experimental Data New Clinical Indications for
PEMF?

• Bassett, CA, Beneficial Effects of
  Electromagnetic Fields. J of Cell Biochemistry.
  1993 51387-393.

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Acute Myocardial Ischemia and Acute Cerebral
Ischemia

• Animal data showing decrease in infarct size.
• Acute affects on blood flow and angiogenesis.
• Questionable effect on superoxide dismutase and
  nitrous oxide.

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Cancer

• Animal data demonstrate decreased growth and
  invasiveness of Meth A sarcoma in Balb C mice,
  encapsulation and nuclear changes.

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Periodontal disease, edentulous jaw, and
extraction sockets

• Animal data show decrease in bone resorption in
  jaws.
• Increased osteogenesis in tooth extraction
  sockets.
• Improved bacterial flora spectrum.

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Diabetes, adult onset

• Clinical benefits on blood glucose reported.
• ? Secondary to Ca effects on insulin secretion.

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Diabetic and alcoholic neuropathy

• Effects on axoplasmic transport.
• Neuronal protein synthesis.
• Ca/neurotransmitter effects at synapse.
• Angiogenesis.

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Ligament/tendon healing

• Animal data showing improved healing.
• Increased collagen and GAG synthesis.
• Increased angiogenesis.

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Peripheral nerve transection/crush

• Animal data showing increased protein synthesis.
• Increased axon migration and function.

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Spinal cord injury

• No direct evidence.
• Data on neuropathy and nerve transection may
  prove beneficial.
• Particularly in crush injuries when sensory and
  motor potential evoked potentials are still
  present.

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ONDAMED

• An integrative biophysics instrument that changes
  the energetic terrain.
• Positive affects on biologic systems with low
  level specific pulsed electromagnetic
  frequencies.
• Specific frequencies via pulse testing provide
  intelligent information.

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Recommended resources

• Bassett, CA. Beneficial Effects of
  Electromagnetic Fields. J of Cell Biochemistry.
  1993 51387-393.
• Holden, K. Pulsed Electromagnetic Field Therapy
  With the Ondamed A Tool for Integrative
  Biophysics. http//www.ondamed.net/web/publication
  s/articles.html. 2009.
• Shupak, N. Therapeutic Uses of Pulsed
  Magentic-Field Exposure A Review. The Radio
  Science Bulletin. 2003 Dec (307) 9-32.

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Contact Information

• Keith R. Holden, M.D.
• Resonance Center
• 496 Osceola Avenue
• Jacksonville Beach, FL 32250
• [phone]
• krholden_at_gmail.com
• www.ResonanceCenterJax.com