Drugs Affecting Gastrointestinal Function

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Drugs Affecting Gastrointestinal Function
Gao Fen-Fei
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OUTLINE

• Peptic Ulcer
• Digestion
• Vomiting
• Diarrhea
• Bile
• Review-Questions

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Ulcer-Background

• Epidemiology
• incidence of a disease 10-12
• DU gt GU (31)
• Etiology
• General consideration No Acid No Ulcer
• Main Destroy Factors ?HCl, ?Pepsin, ?Hp
• Protective Barrier Mucus-HCO3-
• Physiology
• HCl P-cell, H2, M1, G-R, H-pump

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Anti-ulcer Targets

• HCl
• Mucus
• Hp

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Anti-ulcer Classification

• Antacids--- Neutralize HCl
• Gastric Antisecretory Drugs
  HCl secretion
• Antagonize Rs. on Parietal Cell--- H2,M3, G
• Inhibitor of H-Pump
• Protectors of Mucosa
• Agents kill HP

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?. Antacids

• Mechanism
• Alkalizers