Protocol of acute promyelocytic leukemia (AML M3)

1
Protocol of acute promyelocytic leukemia (AML M3)
2
INDUCTION

• ATRA (vesanoid capsules)
  
• 45 mg/m2 P.O. daily till CR or max. of 90
  days.
• Daunorubicin 45 mg/m2 I.V. day 1,2,3.

3
CONSOLIDATION

• Daunorubicin 45 mg/m2 I.V. day 1,2,3 for
  2 courses
  

4
MAINTENANCE

• ATRA 45 mg/m2 P.O. daily for 2 weeks every
  3 months every 2 years.
• 6-Mercaptupurine 60 mg/m2/day P.O.for 2 years.
• Methotrexate 20 mg/m2 I.V.once weekly for 2
  years.