ALUMINA FIBERS IN ORTHOPEDICS IMPLANT: Osteoblast Adhesion Application

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ALUMINA FIBERS IN ORTHOPEDICS IMPLANT Osteoblast
Adhesion Application

• Dr.Hasmaliza Mohamad
• Ruzainah Abdullah
• School of Materials and Mineral Resources
  Engineering,
• Universiti Sains Malaysia,
• 14300 Nibong Tebal,
• Pulau Pinang, Malaysia

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Alumina (Al2O3)

• Alumina is an important engineering
  material for high temperature industries.
• Properties
• High strength and modulus.
• Resistance to attack by molten metals and
  non-oxide materials.
• Chemical inertness in both oxidizing and reducing
  atmosphere.
• Low thermal conductivity and good electrical
  insulation

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Biomedical application of Al2O3

• Dental Implant
• Bone implant
• Joint replacement Knee prostheses, ankle
• joint, shoulders and fingers.
• Implant adhesion Osteoblast adhesion

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Objectives

• To increase the activities of bone cells on the
  surface of material used in the design of
  orthopedic implants.
• Enhanced functions of osteoblasts

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Previous study

• Frequently, problems with orthopaedic implants
  occur owing to either loosening of the implant,
  osseo-degradation of bone surrounding the implant
  or hypersensitivity of the patient to the
  particular metal
• Hydroxyapatite-coated implants have been
  successful for the most part. It has been found
  that bone apposition on the surface of porous
  hydroxyapatite-coated implants is better than
  that on metallic porous coatings

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Previous study (cont..)

• However, numerous problems are still encountered
  with these approaches. For example, the average
  lifetime of hydroxyapatite-coated implants needs
  improvement, owing to high solubility rates that
  can lead to degradation of the coating and
  loosening at the bone-hydroxyapatite interface

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Present study

• Alumina fibers will use to increase the coating
  toughness
• Electrospinning provides opportunities to
  manipulate and control surface area, fiber
  diameter, porosity and pore size of nanofiber
  matrices
• Study the effect of various properties of alumina
  fibers on adhesion

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Synthesis of the alumina fiber

• sol gel ? Electrospinning ? press ? sinter
• The combination of sol-gel processing with
  electrospinning techniques will provides a
  versatile technique for producing ceramics
  nanofibers

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EXPERIMENTAL PROCEDURE Fibre
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SEM image of nanofibers
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The aim of nanoscale alumina in osteoblast
adhesion

• Nanofiber alumina (less than 100 nm in diameter)
  more closely simulates the physical geometry of
  hydroxyapatite crystals and collagen fibers in
  bone that osteoblasts are accustomed to interact
  to.

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Advantages of alumina fibers in osteoblast
adhesion

• Increase the toughness of HAp coating
• Give good adhesion to implant
• Increase the degradation rate of HAp coating