Laboratory of Mycobacterial Diseases and Cellular Immunology

1
Laboratory of Mycobacterial Diseases and Cellular
Immunology

• Lab structure and personnel
• Research interests
• Regulatory responsibilities
• Involvement with the public health community

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Research Sections of the Laboratory of
Mycobacterial Diseases and Cellular Immunology

• Molecular Vaccines
• Mycopathogenesis
• Immune Mechanisms

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LMDCI Molecular Vaccines Section

• Current staff
• Sheldon Morris, P.I.
• Steven Derrick, Ph.D.
• C. Goter Robinson, Ph.D.
• Amy Li Yang, M.S.

• Collaborators
• FDA/CDRH
• NIH/VRC
• NIH/NICHD
• Albert Einstein
• SRI

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LMDCI Research Molecular Vaccines Section

• Development of novel TB DNA vaccines
• Characterization of attenuated Mtb strains
• Identification of drug resistance mechanisms

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LMDCI Mycopathogenesis Section

• Current Staff
• Michael Brennan, P.I.
• Thames Pickett, Ph.D.
• D. Veerabadran, Ph.D.
• Marcela Parra, Ph.D.

• Collaborators
• Institut Pasteur
• Johns Hopkins
• CDC
• Corixa
• Albert Einstein
• University of Sassari

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LMDCI Research Mycopathogenesis Section

• Characterization of the HBHA adhesin
• Characterization of the novel PE gene family of
  Mycobacterium tuberculosis

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LMDCI Immune Mechanisms Section

• Current staff
• Karen Elkins, P.I.
• Siobhan Cowley, Ph.D.
• Ellen Fernandez, Ph.D.
• Carmen Collazo, Ph.D.
• Susan Colombini
• Elizabeth Hamilton
• Anda Meierovics

• Collaborators
• NIH/NIAID
• NIH/NCI
• UMD Baltimore
• Univ. of Victoria
• Oregon Health and Science
• UCLA
• Harvard
• CDC

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LMDCI Research Immune Mechanisms Section

• Determine the basis of innate immune responses to
  LVS
• Determine the role of B cells in immunity to LVS
  and Mtb
• Elucidate protective T cell-mediated immune
  responses to LVS and Mtb

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LMDCI Regulatory Duties

• Provide pre-clinical guidance
• Review IND submissions
• Review BLAs
• Inspect manufacturing facilities
• Review product labeling and advertising
• Review product lot release documents
• Assist in developing regulatory policy

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LMDCI Regulated Products

• VACCINES
• TB, malaria, tularemia, Lyme disease,
• Q fever, leishmania
• IMMUNOTHERAPEUTICS
• BCG, M. vaccae
• DIAGNOSTICS
• Skin test reagents, devices

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Involvement with the Public Health Community

• WHO GAVI committee
• WHO TB Vaccine Initiative Advisory Board
• WHO TB Clinical Trials Working Group
• Standard reagents for the WHO
• CDC skin test studies
• BTEP program

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Involvement with the Public Health Community

• NIH Study Sections
• NIH TB Vaccine Review Committee
• NIH Blue Ribbon Panels
• Advisory Committee for the Elimination of
  Tuberculosis
• Federal TB Task Force
• Editorial Boards for scientific journals