Research for

1
Research for Health Wellbeing
A Strategy for Research and Development to lead
Northern Ireland into the 21st Century
Northern Ireland Forum for Health Social
Care Research 5 November 2003 Rosspark Hotel
2
RD Office Update

• Dr Michael Neely

3
The strands of the HPSS RD Strategy
4
RD Office
Commissioned
admin. Support for
research
UK schemes
(Chapter 5)
(Chapter 5
)
Special initiatives
(Chapter 6)
Dissemination
uptake
(Chapter 4)
HPSS RD
HPSS RD
Education
FUND
FUND
training
(Chapter 8)
(Chapter 8)
(Chapter 4
)
Career
development
(Chapter 4)
Units
(Chapter5)
Responsive-
mode scheme

Research Groups
(Chapter 4)
(Chapter 4)

5
RD Office

• previously

6
CSA Chief Executive
Operational Director
Director of RD for the HPSS
Office Manager
Business Manager
Programme Managers
Strand Leads
Admin Assistants
Clerical Officer
OREC
OREC Manager
Clerical Officer
REC Administrators
7
Programme Managers

• assist their profession(s) benefit from all RD
  Office schemes by promoting opportunities
  acting as an effective link between the Office
  and their profession(s)
• contribute overall functioning RD Office
• provide strategic operational scientific input
• assume responsibility for management of research
  programmes projects

8
RD Strategy Group

• Professor Sean Fulton (Chair)
• Professor Dominic Burke
• Dr Henrietta Campbell
• Professor Roy Crawford
• Professor Bernadette Hannigan
• Miss Judith Hill CBE
• Mr Stephen Hodkinson
• Dr Paula J Kilbane

• Dr Gerry Linden
• Dr Jim Livingstone
• Dr Liz McWhirter
• Dr Michael Scott
• Mr Paul Simpson
• Professor Robert Stout
• Dr Michael Neely (Secretary)

9
RD Office
Commissioned
admin. Support for
research
UK schemes
(Chapter 5)
(Chapter 5
)
Special initiatives
(Chapter 6)
Dissemination
uptake
(Chapter 4)
HPSS RD
HPSS RD
Education
FUND
FUND
training
(Chapter 8)
(Chapter 8)
(Chapter 4
)
Career
development
(Chapter 4)
Units
(Chapter5)
Responsive-
mode scheme

Research Groups
(Chapter 4)
(Chapter 4)

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www.rdo.centralservicesagency.com
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Cochrane

• Cochrane Library access
• Cochrane Systematic Review Courses
• Cochrane Fellowships
• Rivastigmine in Vascular Dementia
• Galantamine in Vascular Dementia
• All Ireland Cochrane Health Libraries Group Prize
  

15
Workshops Seminars

• North South Pharmacy Healthcare Conference(Nov
  02)
• Health Care Medical Textiles (Jan 03)
• Nursing Practice Focused Research (Feb 03)
• Moving Midwifery Forwards (Mar 03)
• Health Services Pharmacy Practice (Apr 03)
• 26th European Cystic Fibrosis Conference (Jun 03)
• All-Ireland Cancer Conference (Oct 03)

16
RD Today

• 1st issue October 2002
• 2nd issue June 2003
• 3rd issue December 2003

17
RD Office
Commissioned
admin. Support for
research
UK schemes
(Chapter 5)
(Chapter 5
)
Special initiatives
(Chapter 6)
Dissemination
uptake
(Chapter 4)
HPSS RD
HPSS RD
Education
FUND
FUND
training
(Chapter 8)
(Chapter 8)
(Chapter 4
)
Career
development
(Chapter 4)
Units
(Chapter5)
Responsive-
mode scheme

Research Groups
(Chapter 4)
(Chapter 4)

18
Career Development

• Research Sabbatical Training scheme
• RD Office/MRC health services fellowship
• Cancer epidemiology fellowship
• International Cancer Nursing fellowship
• National Schemes

19
RD Office
Commissioned
admin. Support for
research
UK schemes
(Chapter 5)
(Chapter 5
)
Special initiatives
(Chapter 6)
Dissemination
uptake
(Chapter 4)
HPSS RD
HPSS RD
Education
FUND
FUND
training
(Chapter 8)
(Chapter 8)
(Chapter 4
)
Career
development
(Chapter 4)
Units
(Chapter5)
Responsive-
mode scheme

Research Groups
(Chapter 4)
(Chapter 4)

20
Small Grant Scheme

• Assessment of movement loci of Total Hip
  Replacements (THRs) and their influence on the
  wear and performance of artificial joint
  replacements in vivo
• A pilot study to devise an experimental
  intervention for patients awaiting coronary
  artery bypass surgery and explore associated
  outcomes
• Cardiorespiratory measurements recorded by the
  LifeShirt system Assessment of test-retest
  reliability, repeatability and responsiveness in
  cystic fibrosis (CF)
• Addressing the healthcare needs of cancer
  patients at the outpatient review clinic a
  qualitative study of the perception and
  experience of patients, nurses and oncologists
• Sequencing and characterisation of Rotavirus
  strains isolated from adults and children in
  Northern Ireland

21
North South Scheme

• Dr Eric McAdams - Prevention and removal of
  pathogenic bacterial biofilms on medical implant
  surfaces
• Professor Derek Middleton - Investigations on the
  extent of KIR gene diversity and its role in
  expression
• Professor Noel Sheehy - Risks and hazards of
  blood donation and transfusion - professional and
  lay knowledge and attitudes to risk in Ireland
• Professor Brendan McCormack - A study to
  determine the contextual indicators impacting on
  effective proactive continence management in
  rehabilitation setting for older people

22
Small Equipment Scheme

• 67 awards made
• education training
• RRGs

23
RD Office
Commissioned
admin. Support for
research
UK schemes
(Chapter 5)
(Chapter 5
)
Special initiatives
(Chapter 6)
Dissemination
uptake
(Chapter 4)
HPSS RD
HPSS RD
Education
FUND
FUND
training
(Chapter 8)
(Chapter 8)
(Chapter 4
)
Career
development
(Chapter 4)
Units
(Chapter5)
Responsive-
mode scheme

Research Groups
(Chapter 4)
(Chapter 4)

24
RRG Additional Call 2003

• Oesophageal adenocarcinoma in Barretts
  oesophagus contribution of the Northern Ireland
  Barretts Register and mathematical modelling
• Long term follow-up of middle-aged men with
  elavated prostatic specific antigen levels a
  population based study
• The psychosocial impact of facial discrepancy
  requiring surgical correction
• Attitudes to breastfeeding A health educational
  initiative with adolescents
• Advanced lipoxidation end-products and the
  pathogenesis of diabetic retinopathy
• Production and secretion of glycated forms of
  intestinal GLP-1 and GIP Involvement in
  hormonal control of glucose metabolism and
  diabetes
• Effects of Omega-3 Fatty Acids on Platelet and
  Vascular reactivity in patients with type 2
  diabetes mellitus and hypertension
• Genetic screening in breast and breast/ovarian
  cancer families

25
RRG Additional Call 2003

• The validation and integration of (18FDG) PET-CT
  functional data into the radiotherapy treatment
  planning process for non-small cell lung cancer
• A comparison of Bobath therapy and gait-specific
  training in acute stroke a randomised
  controlled trial
• Development and clinical validation of a
  respiratory microarray to study the clinical
  significance of concurrent infections of the
  respiratory tract
• A study to compare the efficacy of two potential
  diagnostic assays A Fluorescein conjugated
  monoclonal antibody in vivo assay and nested real
  time PCR assay to rapidly and accurately diagnose
  herpes simplex keratitis
• Determination of platelet BACE activity in
  Alzheimers disease patients and its relationship
  to genetic variation at the BACE locus
• A study of motor function and dopamine
  transporter and receptor status in Parkinson and
  Parkinson plus syndromes using infra-red
  oculography, radionucline and MRI imaging

26
RD Office
Commissioned
admin. Support for
research
UK schemes
(Chapter 5)
(Chapter 5
)
Special initiatives
(Chapter 6)
Dissemination
uptake
(Chapter 4)
HPSS RD
HPSS RD
Education
FUND
FUND
training
(Chapter 8)
(Chapter 8)
(Chapter 4
)
Career
development
(Chapter 4)
Units
(Chapter5)
Responsive-
mode scheme

Research Groups
(Chapter 4)
(Chapter 4)

27
Institute of Child Care Research

• Assistant Director
• Dr Rosemary Kilpatrick
• Youth Development Study (Family Survey)
• Multiple Placements Study 1st phase
• Adolescents in Substitute Care
• Cost of Children (NI) Order Cases
• MOMENTS

28
RD Office
Commissioned
admin. Support for
research
UK schemes
(Chapter 5)
(Chapter 5
)
Special initiatives
(Chapter 6)
Dissemination
uptake
(Chapter 4)
HPSS RD
HPSS RD
Education
FUND
FUND
training
(Chapter 8)
(Chapter 8)
(Chapter 4
)
Career
development
(Chapter 4)
Units
(Chapter5)
Responsive-
mode scheme

Research Groups
(Chapter 4)
(Chapter 4)

29
RD Office Bursary Scheme

• 33 awarded
• NCI Summer Prevention course
• MClinRes

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Fellowships - Clinical Science

• Comparison of the effects of Hypolipidaemic Drugs
  on insulin resistance in Type 2 Diabetes,
  essential Hypertension and mixed Hyperlipidaemia
• A comprehensive investigation of the mechanisms
  that underlie differences between venous and
  arterial grafts
• Development of administration protocols for a
  novel transdermal patch containing
  5-aminolaevulinic acid for use in topical
  photodynamic therapy

31
Fellowships - Health Social Care

• A qualitative study of the experience of cachexia
  in cancer patients
• An investigation of the impact of assertive
  outreach on people with severe and enduring
  mental health problems in Northern Ireland
• Self-management in non cystic fibrosis (CF)
  Bronchiectasis --a randomised controlled trial

32
National Awards

• Primary Care
• Nursing Allied Health Professional
• Evidence Synthesis
• Clinical Scientist
• Public Health Career Scientist

33
RD Office
Commissioned
admin. Support for
research
UK schemes
(Chapter 5)
(Chapter 5
)
Special initiatives
(Chapter 6)
Dissemination
uptake
(Chapter 4)
HPSS RD
HPSS RD
Education
FUND
FUND
training
(Chapter 8)
(Chapter 8)
(Chapter 4
)
Career
development
(Chapter 4)
Units
(Chapter5)
Responsive-
mode scheme

Research Groups
(Chapter 4)
(Chapter 4)

34
Primary Care

• RD Strategy for Primary Care
• Projects/awards
• IfH
• GPARTS
• NPC Researcher Development Award

35
Research Support Centres

• Nucleic Acid Extraction Centre
• Northern Ireland Cancer Trials Unit
• Clinical Research Support Centre

36
Clinical Research Support Centre

• epidemiology
• medical statistics
• health economics
• qualitative research methods
• clinical trials organisation co-ordination
• data management
• intellectual property rights

37
Clinical Research Support Centre

• All Ireland Cooperative Group for Cancer Clinical
  Trials
• Data management Services
• Commercial Clinical Trial Service

38
ALL IRELAND COOPERATIVE GROUP for CANCER CLINICAL
TRIALS
Statistics Data Management Clinical Research
Support Centre
This is the first cooperative group on the island
of Ireland, bringing together those involved in
cancer research and care in both Ireland and
Northern Ireland in a new organisational
arrangement. It is a major demonstration of the
impact of the Cancer Consortium to develop new
and dynamic ways of improving care for cancer
patients. The all-island cooperative group
offers an opportunity to develop clinical trial
activity to a much more sophisticated level, in
cooperation with colleagues in the US, the UK and
the rest of Europe.
Clinicians Investigators Prevention Diagnosis Tr
eatment Surgery
Radiotherapy Chemotherapy Immunotherapy
Hormonal therapy etc.
Administrative Centre ICORG Office
39
ALL IRELAND COOPERATIVE GROUP for CANCER CLINICAL
TRIALS

• The Genesis of a Trial
• Idea - Investigators
• AICG - Preliminary approval
• Protocol development
• PI, Statistician, Data manager, CRA
• Template Guidelines
• AICG - Full Approval
• Initiation of Trial

40
Other

• Imaging Forum
• think create innovate
• Clinical Raman Microscopy Centre
• NI Longitudinal Study
• All Ireland Biobank

41
Research Governance

• Research Governance Framework for Health Social
  Care
• EU Directive
• Research Ethics Committees
• Pathfinder Project

42
RD Office
Commissioned
admin. Support for
research
UK schemes
(Chapter 5)
(Chapter 5
)
Special initiatives
(Chapter 6)
Dissemination
uptake
(Chapter 4)
HPSS RD
HPSS RD
Education
FUND
FUND
training
(Chapter 8)
(Chapter 8)
(Chapter 4
)
Career
development
(Chapter 4)
Units
(Chapter5)
Responsive-
mode scheme

Research Groups
(Chapter 4)
(Chapter 4)

43
New TSN

• Monitoring inequalities in pregnancy outcome in
  NI with UK comparisons
• New TSN in health and social care what are the
  problems?
• Measuring the impact of multisectoral
  partnerships on inequalities in health
• Community Learning Disability Teams in Northern
  Ireland An investigation into their structures,
  functions and effectiveness in preventing people
  with learning disabilities being admitted to
  hospital
• Socio-economic factors and outcomes in Type 2
  diabetes
• Identifying the reasons for and appropriate
  service responses to under-served populations
  with renal failure
• Improving the outcome of pregnancy and early
  infancy with an intervention study in women from
  socially deprived areas of Belfast
• Social inequalities in access and uptake of
  prenatal screening in Northern Ireland

44
Investing for Health

• Prevalence, determinants and strategies for
  countering overweight and obesity in school aged
  children and adolescents a comparison of
  learning disabled and non-learning disabled
  pupils
• A study of the effectiveness and cost
  effectiveness of Public Access Defibrillation in
  urban and rural populations in Northern Ireland
• Investing for Health - Goal 2 Target (I) Is
  this a reasonable way to assess the effectiveness
  of policies to reduce inequalities in health?
• Does a reduction of poverty in the elderly
  improve health and reduce use of primary care
  services?
• Health and social inequalities in the uptake of
  cardiac rehabilitation in Northern Ireland an
  alternative programme for non-attenders