arNOX, AGINGRELATED CELL SURFACE ECTONOX PROTEIN - PowerPoint PPT Presentation

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arNOX, AGINGRELATED CELL SURFACE ECTONOX PROTEIN

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Title: arNOX, AGINGRELATED CELL SURFACE ECTONOX PROTEIN


1
arNOX, AGING-RELATED CELL SURFACE ECTO-NOX PROTEIN
  • D. James Morré and Dorothy Morré
  • Department of Medicinal Chemistry Molecular
    Pharmacology and Department of Foods and
    Nutrition Purdue University, W. Lafayette,
    Indiana 47907

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Preventative target to reduceatherogenic risk in
the elderly
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SOD inhibited reduction of ferricytochrome c
  • Human (Age gt 50y)
  • Buffy coats
  • Sera
  • Saliva
  • Perspiration
  • Late-passage cell culture
  • MCF-10A
  • WI-38
  • Plants
  • Senescent spinach leaves
  • Senescent Aracean spathes

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Morré, D.M, F. Guo and Morré, D.J. 2003 Mol.
Cell. Biochem. 254101-109.
7
  • Coenzyme Q (Q8, Q9 and Q10 but not by Q0, Q2, Q4,
    or Q7)
  • Several Chinese botanicals with antiaging
    activities

Ar NOX inhibited by
Buffy Coats
Morré, D.M and Morré, D.J. 2003 BioFactors
1833-43
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Summary
  • Aging-related NOX
  • Generates superoxide
  • Cells and sera of aged individual (gt50y)
  • Postulated to propagate aging cascade to adjacent
    cells and circulating lipoproteins
  • Ablated by coenzyme Q10 /Antiaging botanicals
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