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Neonatal Surgery PrinII Juan E Gonzalez, CRNA, MS, ARNP

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Intestinal atresia/stenosis. Malrotation. Delivery Room Management of Gastroschisis ... of fetus to swallow amniotic fluid d/t esophageal atresia polyhydramnios ... – PowerPoint PPT presentation

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Title: Neonatal Surgery PrinII Juan E Gonzalez, CRNA, MS, ARNP


1
Neonatal SurgeryPrin-IIJuan E Gonzalez, CRNA,
MS, ARNP
  • Based on prior lecture by
  • John P. McDonough, CRNA, Ed.D., ARNP
  • Professor Director
  • Anesthesiology Nursing

2
Anatomical Differences
3
Pedi vs. Adult Airway
4
Head Position
Visual Alignment of Oral/Pharyngeal/Laryngeal axes
Attempt to achieve sniffing position will
OBSTRUCT pt
5
Intubation
  • Anterior position of larynx large tongue
  • Mask ventilation more difficult than adults
  • Neck/Shoulder roll (compensate for large occiput)
  • Smaller potential submental space in which to
    displace tongue during laryngoscopy
  • Straight blade preferred

6
A little trick
7
To intubate or not to intubateIs that a
question??
  • Most clinical situations require ETT d/t anatomic
    physiologic considerations
  • If anesthesia provided is skillful surgery is
    short and no need for relaxation ? mask
    ventilation or LMA could be considered
  • Controlled vs. Spontaneous Ventilation??
  • If healthy pt short Sx ? spontaneous
    ventilations acceptable
  • If debilitated pt, long-standing dz, circulatory
    instability muscle relaxation needed for Sx ?
    controlled ventilation is only choice

8
Choice of Intubating Technique(patient factors)
  • Awake intubation (topicalization IV
    lido 1.5mg/kg)
  • Causes HTN ? can rupture fragile intracerebral
    vessels (mainly premies)
  • awake intubation OK if
  • Pt is Moribund in need of resuscitation
  • Persistent vomiting

9
Choice of Intubating Technique(patient factors)
  • Asleep intubation
  • IV induction
  • Mask induction

10
Blood Pressure Control
  • Normal newborn SBP 60-70 mm/Hg
  • Controlled hypotension 40-50 mm/Hg
  • SBP lt 40 mm/Hg requires vigorous Rx
  • Fluid (10ml/kg) bolus
  • Oxygenation controlled ventilation
  • Then analgesia
  • titrated doses of ketamine (0.5 mg/kg increments)
  • followed by opioids (fentanyl 2.5 µg/kg
    increments)
  • BEWARE of postop respiratory depression

11
Emergence
  • ? Extubation at conclusion (depends)
  • Reversal of Muscle Relaxant
  • Edrophonium (1mg/kg) will achieve 90 of reversal
    in 2min. Use Atropine 0.01-0.02 mg/kg (Enlon
    Plus) Faster reversal fewer muscarinic
    side-effect
  • Neostigmine (0.06mg/kg) will achieve 90 reversal
    in 10min. Use Glyco (0.01mg/kg) or Atropine
  • If extubating
  • Awake state is associated with control of airway
    reflexes
  • Awake open eyes, grasp ETT (purposeful
    movements), cry (cant be heard d/t ETT but can
    be observed)
  • If partially anesthetized ? laryngospasm, apnea

12
Surgeries in the First Week of Life
  • Congenital Diaphragmatic Hernia (CDH)
  • Omphalocele Gastroschisis
  • Tracheoesophageal Fistula (TEF) (hrs-days to
    diagnose)
  • Intestinal Obstruction (hr-days to diagnose)
  • Meningomyelocele

13
Confounding Factors
  • Prematurity
  • When associated with Resp Distress Syndrome may
    worsen surgical outcome
  • Use of surfactant has increase of survivors
  • Associated Congenital Anomalies
  • Presence of one congenital anomaly increases
    chances of ANOTHER congenital anomaly
  • TEF mortality associated with congenital heart
    defect is far greater than mortality d/t Sx
    correction of TEF
  • TEF (15-25 cardiac anomaly)
  • CDH (25-30 cardiac anomaly)

14
Maternal Cocaine Use in Pregnancy
  • Cocaine reduces catecholamine reuptake
  • Accumulation of catecholamines
  • Circulatory negative effects on uterus, umbilical
    blood vessels (AVA), fetal CV system
  • Premie birth, IU growth retardation, CV abn
  • One report showed low CO SV 1st day of life but
    return to normal 2nd day
  • CV abn
  • Periph pulm stenosis, RV conduction delay, RVH
  • EKG abn
  • ST T wave changes

15
Congenital Diaphragmatic Hernia(CHD)
  • 14000 live births
  • 40-50 mortality (severe lung underdev)
  • 90 detected in 1st week are left sided
  • Defect is more than a hernia in diaphragm
  • Anesthetic techniques dictated by patient
    condition
  • PAP should not exceed 30 cm/H2O

16
Embriologic features of CDH
  • 5th-10th wk the gut is herniated or extruded to
    the extraembryonic coelom
  • 7th wk diaphragm develops ? separate thoracic
    abd cavitity
  • 9th 10th wk developing gut returns to
    peritoneal cavity
  • If diaphragm closure is delayed or incomplete or
    if the gut returns earlier prevent normal diaph
    closure ? CDH ? degrees of herniation of
    intestinal contents into the chest
  • L side closes later than R side ? higher
    incidence on L side (foramen of Bochdalek)

17
CDH scenarios
  • If CDH developed early ? lots of gut pressing on
    chest ? compression of developing lung bud ? very
    small, hypoplastic lung
  • Bil hypoplastic lungs ? no survival
  • If CDH developed later ? normal lung compressed
    by gut
  • Large range of in between
  • Relatively normal pulm vascular bed with various
    degrees of pulm HTN that may revert to normal
  • Severe pulm hypoplasia abn pulm vasculature
    (usually die)

18
CDH Clinical Presentations
  • 1st min APGAR may be WNL (determined by
    oxygenation of placenta)
  • S/S r/t degree of herniation interference with
    pulm Fx (may be evident at first or take hrs to
    dx)
  • Severe case ? fast dx ? scaphoid abdomen d/t
    absence of intraabd contents
  • Breath sounds on affected side are reduced or
    absent
  • CXR confirms Dx quick
  • Supportive Measures
  • ETT controlled ventilation (High PIP ? pneumo)
  • Decompression of stomach

19
Surgery CDH
  • Delay Sx until pt is stable (24-48hr to 1wk)
  • ECMO preop ? weaned from ECMO scheduled for Sx
  • Other pts have Sx while on ECMO remained on
    ECMO up to 30 days
  • CDH pts are surfactant-deficient (ECMO allows
    surfactant system to mature)
  • When is best time for Sx?
  • Wait until pulm vascular resistance is decreased

20
Anesthesia CDH
  • 2 factors to consider
  • Pulm Fx
  • Ability to close abdominal incision
  • If normal lungs small hernia may consider
    extubation _at_ end of Sx or shortly after
  • Most often, stay intubated for airway control
  • After repair, return of gut to abd cavity may be
    difficult (avoid N2O)
  • Lung should be re-expanded gently under DV
    (PIPlt30mmHg).
  • Contralateral pneumo is possible if ( high PIP
    needed (suspected if desaturation and/or
    hemodynamic instability after pressure starts

21
Omphalocele
  • Gut extrudes normally at 5th-10th week
  • Gut normally returns to abdominal cavity at 10
    weeks of intrauterine life
  • Failure of all or part of intestinal contents to
    return ? omphalocele
  • Covered by membrane (amnion). Protects abd
    contents from infection loss of extracellular
    fluid. Sx can wait for several days
  • Umbilical cord at apex of sac
  • Other congenital abnormalities frequently seen
  • 20 have Congenital Heart Lesions
  • Beckwith-Wiedemann Syndrome
  • Omphalocele, Mental retardation, hypoglycemia,
    congenital heart dz, large tongue

22
Gastroschisis
  • Develops later in fetal life, after gut has
    returned to abdomen
  • Interruption of omphalomesenteric artery
  • Dissolution of abdominal wall tissue at base of
    umbilical cord
  • Umbilical cord found to one side of intestinal
    contents
  • Gut herniates through defect
  • Slight or complete
  • No sac (infection loss of extracellular fluid)
    need Sx within 12-24hrs
  • Other defects not frequent
  • GI defects common with both Gastroschisis
    Omphalocele
  • Intestinal atresia/stenosis
  • Malrotation

23
Delivery Room Management of Gastroschisis
  • Controversy
  • C-section advocates
  • Prevent trauma to exposed gut
  • Allows better coordination of team of specialists
  • Vaginal delivery advocates
  • Most pts with abd wall defects are born w/o
    injury to bowel
  • Goal ? Protection of exposed bowel minimization
    of fluid/temp loss
  • bagging pt (placing lower body in sterile,
    clear plastic bag filled with warm saline
    tightened to pts body

24
Gastroschisis Periop Concerns
  • Fluid loss (may need to administer large amounts
    of full-strength balanced salt solutions)
  • Adequacy of peripheral circulation UO reflexes
    appropriate fluid resuscitation
  • Infection
  • Associated Congenital Anomalies
  • Postop HTN Ventilation

25
Gastroschisis Periop Concerns
  • If defect is small ? primary closure
  • Excellent skeletal muscle relaxation needed
  • If defect is large ? difficult to return viscera
    to peritoneal cavity d/t underdevelopment of abd
    muscle peritoneum (no N2O!!)
  • A silo is used to contain/cover viscera q2-3
    days the size of the silo is reduced (staged
    repair) similar to squeezing a tube of toothpaste
  • Pt may feel some discomfort (ketamine 0.5-1mg/kg)
  • Pt is usually not intubated at this time (allows
    assessment of appropriate silo reduction w/o
    impairing ventilation/circulation
  • Final stage is Sx to complete closure of
    abdominal wall

26
Postop Care of Gastroschisis
Omphalocele
  • May need ETT for 3-7 days
  • Postop HTN edema of extremities
  • Increased abd pressure reduces circulation to
    kidneys ? release of renin ? activation of
    renin-angiotensin-aldosterone system ? HTN
  • Obstruction of venous circulation of lower body ?
    edema of legs (large amounts of extracellular
    fluid resuscitation needed)

27
Tracheoesophageal Fistula(TEF)
  • 1-3000 live births
  • 50 have associated congenital
  • anomalies
  • Death d/t
  • prematurity
  • associated congenital heart defect (15-20)
  • 85 fistula from distal trachea to esophagus
    blind proximal esophageal pouch (85-90 are type
    III-B)
  • 10 blind proximal esophageal pouch with no TEF
  • Embryologic defect from imperfect division of
    foregut into the anteriorly positioned larynx
    trachea the posteriorly positioned esophagus

28
Tracheoesophogeal Fistula
29
TEF Clinical Presentation
  • Inability of fetus to swallow amniotic fluid d/t
    esophageal atresia ? polyhydramnios
  • If polyhydramnios seen in U/S ? attempt NG tube
    after delivery (not routine in delivery room so
    TEF may not be seen until pt is fed ? choking
    cyanosis
  • Concerns Aspiration pneumonia Dehydration
  • At times a G-tube is needed prior to repair of
    TEF d/t high degree of reflux pneumonia
  • Actual Surgical repair consists of ligation of
    fistula primary repair with approximation of 2
    ends of esophagus (NG Tube helps surgeon as
    landmark)

30
TEF Anesthetic Considerations
  • If G-tube is present ? open to air kept at head
    of table to prevent kinking/obstruction
  • Intubation Technique (avoid excessive press
    ventilation)
  • Awake
  • Topicalization (2 lido spray 5mg/kg) of airway
    Lido IV (1.5mg/kg)
  • Asleep (two techniques)
  • Inhalation Induction followed by topical lido in
    intubation keeping spontaneous ventilation
  • Inhalation or IV induction w/ intubation after
    paralysis

31
Tracheoesophogeal Fistula
  • Essential airway techniques
  • Avoid excessive positive pressure before
    intubation
  • ETT tip between fistula and carina (perform
    endobronchial intubation start to slowly pull
    ETT back until BBSE again)
  • The ETT may go into the fistula by accident
    during
  • Initial intubation
  • Turning pt
  • Surgical manipulation (surgeon can palpate tip of
    ETT in fistula)
  • Be suspicious if increased difficulty in
    ventilating pt, low O2 sats, low ETCO2
  • A-line indicated
  • Avoid post repair neck extension

32
VATER syndrome
  • Vertebral defects
  • Anal atresia
  • TEF
  • Esophageal atresia
  • Renal dysplasia

33
Intestinal Obstruction(Upper GI obstruction)
  • Seen within 24hrs ? feedings ? vomiting
  • Fluid/electrolyte deficits (mostly Na)
  • Aspiration (awake intubation may be needed)
  • Anesthetic management tailored to
  • Adequate relaxation
  • Repair of defect
  • Closure of abd
  • GETA combined with Caudal
  • May need postop ETT with PEEP

34
Intestinal Obstruction(Lower GI obstruction)
  • Seen b/w 2 to 7 days of age ? progressing
    distension ? little or no stool is passed ?
    vomiting ? fluid/electrolyte imbalance
  • Lots of fluid may be sequestered within the
    intestinal tract (high Na)
  • Preop labs ? Na needs to be gt130mEq/L
  • Preop UO ?1-2ml/kg/hr
  • Imperforate anus should be Dx after birth

35
Lower GI obstruction
  • If minimal or no vomit ? RSI
  • If mod-high vomit ? Awake intubation after
    gastric decompression (even if an NG tube is in,
    there is no guarantee that stomach is empty)
  • No N2O
  • Think twice before electing to extubate

36
Meningomyelocele
  • 5 concerns
  • Infection
  • Fluids
  • Position for tracheal intubation
  • Presence of Arnold-Chiari malformation
  • Hydrocephalus

37
Meningomyelocele
  • Infection Fluid
  • Sac can break/leak d/t trauma, positioning,
    delivery
  • Leakage of CSF (serum levels of Na K) can lead
    to electrolyte problem. Replace with
    full-strength balanced salt
  • If large meningomyelocele long Sx, additional
    third space blood loss may result
  • Position for Intubation
  • Place padding while pt is supine to avoid contact
    of meningomyelocele with hard OR table surface

38
Meningomyelocele
  • Arnold-Chiari Malformation
  • Caudal displacement of brain stem cerebellar
    tonsils into cervical spinal canal
  • Associated with an obliteration of the normal
    exit foramina of 4th ventricle
  • gt90 cases ? hydrocephalus ? shunt Sx
  • Hydrocephalus is usually not present during
    Meningomyelocele repair but later on in postop
  • Unusual breathing or BP patterns ? inc ICP?? ?May
    develop hoarseness feeding difficulties
  • Pts with Arnold-Chiari Malformation,
    hydrocephalus increased ICP ? bilateral vocal
    cord paralysis (cause?)

39
Hydrocephalus
  • May occur after closure of meningomyelocele d/t
    Arnold-Chiari Malf
  • Cranial sutures of neonates are open
  • Increases in ICP are minimized/blunted
  • Pt with hydrocephalus eventually has increase in
    head size, inc ICP ? lethargy, vomiting,
    cardioresp problems

40
HydrocephalusAnesthetic Approach
  • Intubation technique depends on condition
  • Major issue airway protection control of ICP
  • Awake intubation
  • Laryngoscopy, crying, struggling, straining ?
    increase ICP
  • Asleep intubation may be preferred
  • RSI (4-5mg/kg Pentothal or 2-3mg/kg Propofol
    Sux)
  • Hyperventilation Barbiturate will control ICP
  • VAA, N2O, opioids for maintenance
  • Keep intubated with PEEP postop if preop apnea
    bradycardia was seen as result of inc ICP

41
Surgical Procedures in the First Month of Life
  • E-lap for Necrotizing Enterocolitis (see Pedi
    Lecture by G. Hogan)
  • Pyloric Stenosis (See Pedi Lecture by G.
    Hogan)
  • Inguinal Hernia repair
  • PDA ligation
  • Placement of CVP

42
Inguinal Hernia Repair(IHR)
  • Statistics
  • Of 100 infants lt2 month old who needed IHR
  • 30 were premies, 42 h/o RDS, 16 were on
    Ventilators, 19 h/o Cong Heart dz
  • 31 had incarcerated hernias, 9 had intestinal
    obstruction, 2 had gonadal infarction
  • Data precludes waiting until premie reaches 6mo
    or 1yr before electivesx

43
Inguinal Hernia RepairAnesthetic Techniques
  • GA (with or w/o local as adjunct)
  • Regional (combined with GA)
  • Ilioinguinal-iliohypogastric nerve block
  • 0.25 Bupivacaine 3mg/kg with epi affords
    excellent postop analgesia w/o need for opioids

44
Inguinal Hernia RepairPost Op Apnea in Premies
  • Premies can develop apnea postop ? prolonged
    associated with bradycardia
  • Respond well to O2 Tx stimulation
  • Rarely reintubation is needed postop but
    respiratory status must be closely monitored
  • Consensus today
  • Premies younger than 50wks postconceptual age
    should stay overnight

45
Ligation of PDA
  • Number of small premies is increasing ? number of
    pts with PDAs with heart failure resp failure
    is ALSO increasing
  • Prostaglandin relaxes smooth muscle of PDA
  • Indomethacin (Prostaglandin Synthetase inhibitor)
    is used to close the PDA
  • Indomethacin is usually unsuccessful in Tx of
    small premies because of lack of muscle within
    PDA
  • Maximal medical management with fluid restriction
    diuretics
  • Usually stay intubated postop

46
Placement of Central Venous
Catheter
  • Monitoring lytes for Hyperal
  • IV meds
  • 3 major concerns
  • Airway management (ETT)
  • Pneumothorax
  • Bleeding (hemothorax, hypovolemia)

47
References
  • Barash 1080-1084, 1098-1112
  • NZ 1148-1164
  • Cote 5-24, 353-395
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