P2X receptors are ATPgated ion channels

1
P2X receptors are ATP-gated ion channels P2X3
subunits are a critical component of the
receptor expressed by pain-sensing primary
afferent neurons P2X2 and P2X3 subunits form a
heteromeric channel with properties closely
resembling those in afferent neurons In
heterologous expression, channels can be
reversibly inactivated by disulfide bond
formation between cysteines in different
subunits Patterns of this intersubunit disulfide
formation show the arrangement of the P2X3
subunits and P2X2 subunits in the channel Jiang
LH, Kim M, Spelta V, Bo X, Surprenant A, North RA
(2003) Subunit arrangement in P2X receptors. J
Neurosci 238903-8910 North RA (2004) P2X3
receptors and peripheral pain mechanisms. J
Physiol 554301-308