StructuralFunctional Study of AD

1
Structural/Functional Study of AD

• PI Reisa Sperling
• Multi-Site (Mass General and Brigham/Womens)
• Associative Memory Paradigm
• Hippocampus, Inferior Frontal, Fusiform

2
fMRI Block Design Paradigm

• Face-Name Pairs
• Novel
• Repeated

Contrast-of-Interest Novel-vs-Repeated
3
Preliminary Data

• Thirteen AD subjects completed study with all
  three adequate fMRI scan sessions
• Eight subjects on MGH Siemens 3T (Trio)
• Five subjects on BWH GE 3T (long bore)
• No cross-site data

4
Test-Retest Assessment
MGH
BWH
Percent N-v-R Contrast
Test
Retest
5
T2 Mapping

• Same Agar Phantom
• EPI Sequences TE 30, 35, 40, 45 ms
• Average T2
• 42.03 ms (GE)
• 42.22 ms (Siemens)

6
Reisa Sperling R01 Proposal Feb 05

• ADNI Ancillary Studies PA
• Reproducibility of fMRI
• Face-name associative memory
• Relationship of fMRI to clinical variablilites
• Two sites, BWH, MGH
• Study structure parallels main ADNI study
• Preparatory
• Longitudinal

7

• Aim 1 quantify cross-scanner reproducibility and
  test-retest stability..
• Compare extent and magnitude of activation within
  each ROI across scanners
• ICC reproducibility analyses (Zou in press)
• Compare within subject and between subject
  variance

8
(No Transcript)
9
(No Transcript)
10
fMRI AMPA Potentiator Study Design
LY451395 (0.2 mg BID) or Placebo
LY451395 (1.0 mg BID) or Placebo
Baseline
ScreeningVisit
Scan 3
Scan 1
Scan 2
-7 to -9days
Week 9
Week 0
Week 5
11
(No Transcript)
12
fMRI Block Design Test-Retest Reliability in AD
patient
13
Differences in prefrontal activation in LY451395
vs. placebo
Session 3 gt Session 1 for Drug (n4) gt
Placebo (n9)