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Surveillance in Kenya: SOAR in AME

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Surveillance in Kenya: SOAR in AME. J rg Sievers, D.Phil. Africa / Middle East ... pneumoniae and Haemophilus influenzae in Africa & Middle East Region ... – PowerPoint PPT presentation

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Title: Surveillance in Kenya: SOAR in AME


1
Surveillance in Kenya SOAR in AME
  • Jörg Sievers, D.Phil
  • Africa / Middle East
  • Clinical Development Medical Affairs
  • 17 November 2003, Nairobi

2
SOAR in AME
Survey Of Antibiotic Resistance in Streptococcus
pneumoniae and Haemophilus influenzae in Africa
Middle East Region
3
SOAR in AME
  • Objective to evaluate, record and analyse the
    comparative activity of a range of antibiotics
    against S. pneumoniae and H. influenzae
  • 1091 H. influenzae and 1154 S. pneumoniae
    isolates collected and tested
  • Susceptibility testing using Etest (penicillin,
    ampicillin, co-amoxiclav, cefaclor, cefuroxime,
    cefprozil, azithromycin, clarithromycin and
    others)

4
S. pneumoniae penicillin resistance
Turkey
24 1
Kuwait
66 0
Lebanon
59 9
Jordan
47 0
Pakistan
Tunisia
11 0
32 18
UAE
71 6
Saudi Arabia
Egypt
38 13
94 0
Kenya
45 3
South Africa
30 2
Penicillin-intermediate (MIC 0.12 1
µg/ml) Penicillin-resistant (MIC ? 2 µg/ml)
5
SOAR in AME - Kenya
6
SOAR in AME - Area
7
H. influenzae b-lactamase production
Turkey
5
Kuwait
26
Jordan
34
Pakistan
Tunisia
3
18
UAE
10
Saudi Arabia
25
Kenya
67
South Africa
7
8
SOAR in AME - Kenya
9
SOAR in AME - Area
10
Conclusions
  • gt 95 of Kenyan S. pneumoniae isolates were
    susceptible to co-amoxiclav and cefuroxime
    (NCCLS, PK/PD).
  • 45 of Kenyan S. pneumoniae isolates were
    penicillin-intermediate and 3 were
    penicillin-resistant.
  • S. pneumoniae resistance to azithromycin,
    clarithromycin and co-trimoxazole appears to be
    increasing in Kenya.
  • All (9/9) Kenyan H. influenzae isolates were
    susceptible to co-amoxiclav, cefuroxime and
    ciprofloxacin.
  • The prevalence of b-lactamase-positive H.
    influenzae was high in Kenya (6/9).
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