Slides for NIDDK lecture 1 NAASO 2000'

1
Prof. W. Philip T. James International Obesity
TaskForce
The greatest global health challenge of this
century a legacy of deprivation ?
2
Population (in millions) at risk of and affected
by micronutrient malnutrition by WHO Region, 1991.
3
Childhood malnutrition the dominant problem of
stunting
4
(No Transcript)
5
The link between low birth weight and stunting
6
Lifecycle the proposed causal links
7
Nutrition over the life cycle the changing
challenges of preventing physical and mental
disability with an increasing life expectancy
8
Proportion of the population aged 60 and over, by
country category, 1950-2050
9
(No Transcript)
10
(No Transcript)
11
(No Transcript)
12
OBESITY AS A DISEASE International
Classification of Disease (ICD) system
13
(No Transcript)
14
(No Transcript)
15
(No Transcript)
16
(No Transcript)
17
The Interactions of smoking and excess weight on
mortality.
18
(No Transcript)
19
(No Transcript)
20
(No Transcript)
21
(No Transcript)
22
Percentage distribution of overweight and obesity
in women 15-49 yrs. in different regions of
developing countries and in the USA
Martorell et al. 2000. E J Clin Nutr, 54,247-252.
23
(No Transcript)
24
Prevalence of obese and extremely obese children
(6-14 years) Izumiohtsu City, Japan, 1974-93
25
(No Transcript)
26
Childhood overweight in developing countries
Within country analyses-
No relationship to family size, car or TV
ownership. 1984-1996 studies in 25 country
surveys of women and child health by USAID.
Horgan, Bellizzi and Dietz, 2000. IOTF.
27
(No Transcript)
28
The Asia-Pacific
perspective
Redefining
obesity
and its
treatment
February 2000
World Health Organization Western Pacific Region
IASO INTERNATIONAL ASSOCIATION FOR THE STUD OF
OBESITY
International Obesity TaskForce
29
(No Transcript)
30
(No Transcript)
31
Asian obesity

• Amplified hazards ?
• Selective abdominal obesity
• Environmental or genetic ?
• Fetal postnatal malnutrition with later rapid
  weight gain.
• Experimental selective programming of
  glucocorticoid organ and site specific
  metabolism.
• Role of infection adipocyte cytokine
  production their impact on insulin resistance.

32
(No Transcript)
33
Adult diabetes and glucose intolerance after
fetal nutritional deprivation.
34
Fetal and childhood nutrition in relation to
women's adult abdominal adiposity
Regressions
137 women multiregression model. Controlling
for fat. Birthweight significantly inversely
related to W/H and the most powerful predictor.
INCAP data.
plt0.05 plt0.01
Shroeder, Martorell Flores. Am J Epid,
199949177-185
35
(No Transcript)
36
(No Transcript)
37
(No Transcript)
38
(No Transcript)
39
(No Transcript)
40
Risk in Indian Women 5 City Study
Singh et al. J. Cardiovasc risk, 5 73-77
41
(No Transcript)
42
(No Transcript)
43
(No Transcript)
44
(No Transcript)
45
(No Transcript)
46
(No Transcript)
47
(No Transcript)
48
Physical activity and obesity in the EU
obese
Martinez-Gonzalez et al. IJO, 1999231192
49
Relationship between dietary composition and
Gross National Product per capita (1990)
Predominantly urban areas