UCL Business PLC

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UCL Business Investor BreakfastUCL Consultants
Ltd Susanne Westfold-Scott
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Background

• UCL Consultants is a wholly owned company of
  University College London
• UCLC is the contracting party for staff
  undertaking private consultancy work

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Services

• For staff
• Professional Indemnity Insurance
• Contracting and financial resources
• For Clients
• A one-stop office for all contractual and
  financial transactions
• Fast, efficient and responsive service

Confidentiality

• We understand the importance of confidentiality
  and this is key to UCLCs role!

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Projects

• From one-day..
• Feasibility Studies
• Proof of concept
• Expert witness work
• to multi-party and larger sub-contracted
  projects

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Benefits of using UCL Consultants

• Consultancy remains focused and strategic
• Client has much closer control of the project
• Cost effective and efficient way of funding short
  term solutions
• Provides next step direction

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Contact

• UCL Consultants Ltd
• The Network Building
• 97 Tottenham Court Road
• London
• W1T 4TP
• T 44 (0)20 7679 9794
• F 44 (0)20 7679 9838
• E enquiries_at_uclconsultants.com
• www.uclconsultants.com

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UCL Business Investor BreakfastUCL
ConsultantsJane Fenoulhet
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UCL Humanities for Business

• Provides thinking technologies for senior
  managers
• Delivered by top scholars from across the
  humanities drawing on their wealth of knowledge
  of European philosophy and culture to give
  businesses novel ways of thinking about current
  challenges
• Great minds through the centuries have wrestled
  with ideas on leadership, trust, creativity,
  power, survival, doubt, ethics, authenticity
• We team the great minds of the past with the best
  minds of today in their fields and bring them to
  bear on business problems.

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What works best

• Initial consultation between H4B representatives
  and a companys HR Director or senior manager to
  identify business needs.
• - H4B represented by a senior academic and a
  facilitator with a combined business and
  humanities background.
• Seminar focusing on a selected theme conducted
  in an atmosphere of openness coupled with
  confidentiality
• Follow-up possibilities including
• seminars on topics arising from the first seminar
• consultancy with a particular academic
• consultancy using a particular approach drama,
  poetry, philosophy, novels, fine art

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An example Leadership from the perspective of
literature

• Shakespeares Henry V. What does it feel like to
  be a leader? How authentic is Henry being with
  those around him? When is he play-acting? Is
  inauthenticity more effective?
• Group translates to their situation gives
  insights gained
• Macchiavellis Prince. Presenter introduces key
  concepts through short readings should a leader
  strive to be loved? Is it better to be feared? To
  inspire trust?
• Agree the thinking technology to be used.

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Leadership from the perspectives of philosophy
and classics

• Philosophy provides thinking technologies for
  solving many human dilemmas. The concept of the
  wisdom of crowds', for example, provides a
  recipe consisting of steps for working out when
  to consult staff or customers
• Classical Greece and Rome offer examples of
  leadership that have reverberated throughout
  western European culture. A current favourite is
  Pericles and how to survive turbulence.

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How it works

• No preparation
• Intellectual stimulation
• Open discussion
• Managed discussion
• High-level discussion
• Ideas to take away, develop, apply
• Pleasures and uses of cultural capital

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UCL Business Investor BreakfastUCL
ConsultantsProfessor John Wood and Dr Rick Fagan
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Consulting in the pain field the challenge

• Almost 1 in 5 people have pain that is poorly
  treated by current drugs
• How are the strategic objectives of drug
  companies defined?
• Can scientists relate their skills to the
  requirements of investors?
• Do managers need to understand the science?
• Why have drug companies failed to make new
  analgesics?

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Consulting in the pain field the problems

• Short-term-ism, me-too-ism and a dialogue of the
  deaf between scientists and salesman
• Scientific issues definition of pain subtypes,
  genetic variation in mechanisms of disease and
  drug metabolism, stupid screens, unexpected side
  effects, high risk of first-in-class drugs, the
  wonders of the placebo effect
• Regulatory issues the problem of Phase III
  trials. Fear and the FDA. Marketing and medical
  versus scientific costs.
• The conundrum science is slow, investors have
  time constraints

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Ionix a missed opportunity?

• Diverging management and scientific agendas (VCs
  changed strategy)
• Excellent validated targets and new compound
  classes established big Pharma now following up
  here
• New Building, high burn rate, inflated initial
  valuation
• Trade sale strategy focus on acquisitions
  incompatible with a long view of drug development
• Enforced sale with 6 months cash left

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Terry Snutch and Neuromed a paradigm for
start-up drug development

• Smart screens (real neurons)
• Good science (world-leading technical insights)
• Low cost academics (!)
• No initial VC pressure
• No time pressure
• Small VC investment (2million), strategic
  alliances with e.g. Merck
• Now 126 million dollars and 70 employees
• 3 compounds, 3 distinct targets all in phase III !

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What UCL can offer in the Pain field

• Preclinical excellence in the London Pain
  consortium
• Human genetics of pain leading to new targets (a
  new human pain syndrome mapped at UCL in August
  2 more to come)
• Specialised electrophysiology and behavioural
  insights into new compounds
• Clinical excellence in the London Pain Centre
  being developed with Imperial College and Kings
  College

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What UCL can offer

• Critical assessment of new drug targets and
  validation in animal models and in man through
  genome wide profiling
• The biggest Neuroscience community in Europe (ION
  a particular jewel) combined with excellence in
  genetics and pharmacology
• Innovation and new targets developed within UCL
• International gossip hub for unpublished hot
  data!
• Clinical trial design and implementation
• Expertise at a very low cost

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UCL Business Investor BreakfastUCL
ConsultantsProfessor Anthony Segal
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Tony (Anthony W) Segal - Qualifications

• EDUCATION Milton
  School, Zimbabwe (S. Rhodesia)
  
  University of Cape Town, South Africa
• QUALIFICATIONS
• M.B., Ch.B. University of Cape Town 1967
• M.R.C.P. (U.K.) Royal College of
  Physicians 1971
• M.Sc. (Biochemistry) University of London 1973
• M.D. University of Cape Town 1974
• Ph.D. University of London 1979
• D.Sc. (Science) University of London 1984
• F.R.C.P. Royal College of Physicians 1987
• FMedSci Academy of Medical Sciences 1998
• FRS The Royal Society 1998
• SPECIALIST ACCREDITATION
• a) Specialist Physician in General (Internal)
  Medicine
• b) Specialist Gastroenterologist
• PRESENT APPOINTMENT

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AW Segal - Research

• International authority on
• Immunology, with special interest in neutrophil
  function. Covers free radicals, antioxidants etc.
• Crohns disease and other bowel diseases.

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A W Segal - Commercial Experience

• Co-founder of
• University Diagnostics First commercial company
  to perform DNA based diagnostics in the UK.
• Sold to The Laboratory of the Government Chemist
• Inpharmatica First commercial bioinformatics
  company.
• Sold to Galapagos Genomics
• Arrow Therapeutics Antibiotic and antiviral
  therapeutic company.
• Sold to Astra Zeneca

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A W Segal contact information

• Department of Medicine,
• UCL,
• Rayne Institute,
• 5 University Street,
• London WC1E 6JJ
• Telephone [phone] (PA)
• Emailt.segal_at_ucl.ac.uk

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UCL Business Investor BreakfastUCL
ConsultantsProfessor Phil Treleaven
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Introducing UCL Computer Science

• UCL Computer Science is one of the top CS
  Departments in Europe.
• Key Facts
• 42 Academic FTE
• 45 Research FTE
• 54 CAT A staff
• 100 Research Students
• 4 RS / RAE / EPSRC Advanced Research Fellows
• Active Research Grants in 2007 21m
• 27.8m expenditure Jan 01 Jan 07
• Focuses on three principal industry sectors
• Financial Services Industry
• Creative Industries
• Bioscience
• Encouraging entrepreneurship

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UCL CS Research Groups

• Networks and Communications
• Human Computer Interaction
• Software Systems Engineering
• Computational Statistics and Machine Learning
• Financial Computing
• Graphics and Virtual Environments
• Vision and Image Processing
• Bioinformatics
• Adjunct Groups
• UCL_at_Adastral.Park
• UCLIC
• JDI
• Centre for Security and Crime Science

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Financial Computing and Technology
Virtual Trading Floor

• Technology
• Reuters APIs
• Algorithmic Trading Systems
• Risk Systems
• Hedge Fund Systems and back testing models

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Creative Industries

• Fashion and Retail Technology
• Working with the 14 largest Retailers e.g. MS,
  Tesco
• Pioneered 3D Body Scanning, measured 11,000
  people
• Produce size charts, custom fit mannequins
• Looking as Virtual Shopping, etc.
• Broadcast Media
• Work on Video Games (EA) etc.
• Cross-Media Platforms social networks
• Very high-speed video

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3D Body Scanning fashion and healthcare
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Cross-media (vertical integration) Platforms
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UCL CS Collaboration

• Low-cost prototyping for the Financial and
  Creative Industries
• 400 students looking for industry-oriented
  projects
• Undergrads - October to March
• Masters - June to September
• PhDs - three years
• Major companies - consultancy and student
  internships
• Start-ups - prototyping or road testing

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Bio Nano Consulting Ltd

• Dr David Sarphie

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Bio Nano Consulting
...using Nanotech tools to address Biotech
problems...
Commercially-focused problem-solving
consultancy with nanotechnology-biomedical
expertise capabilities
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BNC partner institutions
....we put together multi-disciplinary teams of
experts to address problems from industry...
Virtual prototyping
Rapid prototyping
Nano-metrology characterisation
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Investment from DTI and LDA

• 4.95m invested in infrastructure,
  instrumentation and working capital at 3 sites
  LCN, IBE NPL
• Virtual prototyping,
  nano-tools 3 D viz
• Rapid prototyping
  characterisation
• Characterisation
  nano-analysis

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BNC A novel model for accessing world-class
research
Instrumentation Facilities

• Industry Standard
• Project Management
• Client Management

Industry Research Contract
Expertise

• Clients
• Pharmaceutical
• Biotech
• Med-tech

Decreasing risk in R D project delivery
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Technology Capabilities
Drug Screening Technologies
Bio-compatible Nanomaterials
Technologies for Diagnosis
Lab-on-a-chip Screening
Molecular Simulation
Bio-nano Particles
Degenerative Disease Studies
Bio-nano Sensors
Advanced Medical Imaging
Self-assembled Bio-structures
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Prototyping/characterisation tools
Reactive Ion Etch
Laser Micromachining
Combined Atomic Force Raman Microscopy
Dip Pen Nanolithography
Scanning Ellipsometry
Scanning Ion Conductance Microscopy
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Current clients
...we work with clients from biotech,
pharmaceutical, med-tech sectors, as well as
government .....
Analyze binding affinity for novel antibiotic
Global diagnostics company
Characterise novel design of glucose test strip

University diagnostics spinout
Development project
Contract to manage bio-nano theme
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Commercial Project Targanta Characterisation
of drug-target interaction

• Client Targanta (US biotech)
• Project Assess drug-target affinity
• Technique micro-cantilevers
• Functionalised with specific peptides

Schematic showing the nanomechanics of
glycopeptide binding to a cantilever coated with
peptide self-assembled monolayer. Bending is
detected optically.
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Areas of potential interest for VCs

• Characterisation of medical products
• Nano-scale characterisation of pharmaceutical
  activity
• Rapid prototyping on micron-scale
• Micro-array/micro-fluidics
• Design, prototyping, and testing
• Bio-sensors
• Design, development characterisation

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Bio Nano Consulting
...using nanotechnology tools to address
biotechnology problems...
Dr David Sarphie, CEO david.sarphie_at_bio-nano-cons
ulting.com Sept 2008
May 2008