Alabama Neuroscience Blueprint Core Center

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Alabama Neuroscience Blueprint Core Center

• Core E
• In Vivo Physiology Phenotyping

Core Directors J. Michael Wyss and Tim R. Nagy
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In Vivo Physiology Phenotyping

• Blood Pressure
• Heart Rate
• EEG/new Non-invasive
• Seizure Detection
• Learning and Memory
• Body Composition
• Metabolism

Tinsley Harrison Tower 9th Floor
Volker Hall G008
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Blood Pressure, Heart Rate, and EEG
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Direct measurements

• Telemetry (Implantable devices)
• Blood pressure
• Heart rate
• EEG
• Surgery
• Animal in home cage
• Signals relayed via a base under cage

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Indirect measurements

• Tail cuff measurements
• Blood pressure
• Heart rate
• No surgery
• Placed in restraint
• TO BE ADDED IN LATE 2008
• Non-invasive seizure detection module

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Learning and Memory
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Intellicage system

• Screening for behavioral and cognitive
  malfunctions in mice living in groups.
• Allows normal social behavior
• Transponders can track individual behavior.
• Short and long-term studies possible

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• Other learning and memory tests
• Grip strength
• Mazes
• Rotorod
• Contact Thomas van Groen 4-5940

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Body composition
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Dual-energy X-ray absorptiometry

• Lunar Piximus
• Measures fat mass, lean mass, bone mineral
  content and density
• Need anesthesia

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Rat DXA
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Quantitative Magnetic Resonance

• Echo Medical
• Fat and lean mass
• Rats, mice, tissues, biopsies
• No anesthesia

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Energy ExpenditureFeeding and Activity
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• Energy expenditure
• Detailed food intake
• Meal size
• Meal frequency
• Timing of meals
• Activity
• Locomotor
• Fine movements
• Different areas

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Core EIn Vivo Physiology Phenotyping

• Directors J. Michael Wyss
• Tim R. Nagy
• Contact personnel
• Blood pressure Ning Peng 4-5940
• Behavioral Thomas van Groen 4-5940
• Body composition/Metabolism Maria Johnson 4-4008