Chair : Dr' Michael M'C' Lai

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The National Research Program for Genomic
Medicine (NRPGM)
Chair Dr. Michael M.C. Lai Distinguished
Research Fellow IMB Academician, Academia
Sinica Co-Chair Dr. Ding-Shinn Chen Dean of
College of Medicine, National Taiwan University
Academician Coordinate Director Dr. Che-Kun
James Shen Distinguished Research Fellow IMB
Academician, Academia Sinica Executive
Secretary Dr. Pei-Jer Chen Director of Graduate
Institute of Clinical Medicine, National Taiwan
University Academician
2007/01/09
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A Glance at NRPGM

• Precursor period (1997-2001)Genomic Frontier
  Program
• Three stages of implementation from bench to
  bedside

(2006-10)
(2002-05)
ELSI Ethical, Legal, and Social Implications
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A Glance at NRPGM
Core Facilities Service RD
Research Projects
International Collaborations
Industrial Collaborations
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A1 Mouse Mutagenesis Program Core Facility
A2 Functional and Micro-Magnetic Resonance
Imaging Center
AAnimal Models for Human Diseases and
Phenotyping Facilities
A3 Molecular and Genetic Imaging Core
NRPGM National Core Facilities
A4 Transgenic Mouse Model Core Facility
A5 Optical and Scanning Probe Microscopy Core
Facility
B1 National Clinical Core for Genomic Medicine
BClinical Sample Banks for Genomics
B3 Tumor Tissue Bank in Southern Taiwan
C1 National High-Throughput Facility for Physical
Mapping and DNA Sequencing
C2 National Genotyping Center
CFacilities for Basic Genomics
C3 Microarray and Gene Expression Analysis Core
Facility
C5 Microarray and SNP Core Facility for Genomic
Medicine
C6 RNAi Core Facility
D1 Core Facility of Recombinant Protein Production
D2 Core Facilities for Proteomics and Technology
Development
DFacilities for Proteomics and Structural
Genomics
D3 High-Throughput Protein X-ray Crystallography
Core
D4 Synchrotron Radiation Protein Crystallography
Facility
D5 High-Field Nuclear Magnetic Resonance Center
E2 Bioinformatics Core for Genomic Medicine and
Biotechnology Development
EFacilities for Bioinformatics
E3 Advanced Bioinformatics Core
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Five Major Activities for Core Facilities

Core Facilities
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Mouse Models of Human Diseases
Identified Through ENU Mutagenesis Program

• Neurological necrotizing encephalopathy,
  hydrocephalus, brain atrophy, pain insensitivity
• Cardiovascular arrhythmia, aortic stenosis
• Renal hydronephrosis
• Hematology lymphopenia
• Pharmacogenetics phenobarbital resistance
• Metabolic branched chain amino acids elevation
• Metabolomics approach identified a mouse model
  of a genetic metabolic disease
• fatty acid oxidation defects

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International Collaborations
A-IMBN
Research network
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Industrial Collaborations

• IBM Taiwan Corporation
• Life Sciences Center of Excellence.
  Bioiofrmatics
• HP
• A genomic database and a common platform (IP
  and Technology Transfer)

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Second Stage
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NRPGM- Major Accomplishments

• Set up core facility infrastructure
• 19 national core facilities
• Research project
• Identified a genetic marker for the Stevens
  Johnson Syndrome against carbamazepine and
  allopurinol
• Identified a gene for inherited form of
  osteonecrosis
• Discovered a virulence gene in Taiwan specific
  Klebsiella pneumoniae
• Framework for international collaboration and
  technology transfer
• Joined RNAi Consortium (MIT, USA)

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Future Planning (2010- )
Third Stage
INNOVATIVE RESEARCH
CANCER LIVER LUNG
INFECTIOUS DISEASES
HIGHLY HERITABLE DISEASES
ELSI
Bio-medical Industry
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Academia sinica

• Genomic medicine, Pharmacogenomics
• High-throughout drug screening
• Infectious diseases
• Structural biology

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THANK YOU http//nrpgm.sinica.edu.tw/