Schizophrenia and Antipsychotics

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Schizophrenia and Antipsychotics

• Schizophrenia
• Symptoms
• Diagnosis
• Pre-clinical models
• Etiology
• Antipsychotics
• Classical
• Mechanism
• Side effects
• Atypical

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Schizophrenia

• Psychosis
• Statistics
• Prevalence
• Onset
• Cost

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Schizophrenia

• Symptoms
• Classification
• Type
• Catatonic
• Paranoid
• Hebephrenic
• Undifferentiated
• Positive/Negative Symptoms

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Antipsychotics (Neuroleptics)

• Classical
• Phenothiazines
• Chlorpromazine
• Phenothiazine core, different R groups
• Butyrophenones

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Antipsychotics

• Pharmacokinetics
• GI tract aborption
• IM administration
• Distribution/concentration
• Lungs, liver
• Depot binding
• Metabolism
• Half-life

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Antipsychotics

• Effectiveness
• Early (week)
• Later (few weeks)
• Law of thirds
• Maintenance

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Antipsychotics

• Mechanism
• Dopamine
• Receptor antagonism
• Receptor binding
• DA turnover
• Prolactin Release

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Antipsychotics

• Side effects
• Parkinsonism
• Tremors, akinesia, rigidity, akathesia
• Tardive dyskinesia
• Stereotyped movements of face, others
• Neuroendocrine effects
• Prolactin release
• Neuroleptic malignant syndrome
• lethal
• Others

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Antipsychotics

• Tolerance
• Antipsychotic effects
• Side effects
• Dependence
• No withdrawal, but unmasking TD
• Abuse
• No euphria
• Unpleasant side effects

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Antipsychotics

• Atypical
• Selective D2 antagonists
• Broad-spectrum
• Clozapine
• Risperidone
• DA system stabilizers