Milestones in our understanding of CF

1
Milestones in our understanding of CF
30 20 10 5
Denotes Contributions of JHU to CF
Age of survival
RDP established (Guggino)
1800s
1953
1960s
1938
1970s
1980s
1989
CF is a distinct clinical entity (Andersen)
Improvements in nutrition, lung, and GI
therapies.
Identification of CFTR using positional cloning
methods
Elevated sweat electrolytes in patients with
CF (Di SantAgnese)
children will soon die whose forehead tastes
salty when kissed
Beginning of the CF Foundations
G551D Mutation (Cutting)
Shwachman interns in the Harriet Lane Service
Sweat gland (Brusilow)
Genetic counseling (Childs)
First study of antibiotic therapy (Rosenstein)
Ella Oppenheimer defines the pathology
Development of sweat test (Gibson Cooke)
2
Milestones in our understanding of CF
30 20 10 5
Denotes Contributions of JHU to CF
Age of survival
Studies of modifier genes (Cutting)
1989
1996
2000
2004
The steady improvement in clinical care continued
through the Nineties. Establishment of adult
care centers.
CFTR functions as a regulator (Egan, Guggino)
First AAV gene therapy trials (Flotte, Guggino,
Carter)
First protein repair in patients (Zeitlin)
Among the first sites of the TDN (Zeitlin)
Sites for genomics and proteomics centers
(Zeitlin, Pollard, Boyle)
Source Littlewood 2002
3
Milestones in our understanding of CF
30 20 10 5
Denotes Contributions of JHU to CF
Age of survival
Success in studies of modifier genes (Cutting)
2005
2006
The steady improvement in clinical care continued
through the Nineties. Establishment of adult
care centers.
Phase I trial of Moli 901 (Zeitlin)
Inhibitiot of ERAD rescues ?F508 CFTR (Zeitlin)
Discovery of Genes other than CFTR cause CF
(Cutting)
First preimplantation CF diagnosis at JHU
(Cutting)
Source Littlewood 2002