Echocardiography for Moleculer Cardiology Reseach

1
Echocardiography for Moleculer Cardiology
Reseach

• Yibin Xie

2
Echocardiography

• ?????

Emitter receiver
Emitted and reflected Ultrasound beams
Heart
3

• The image of heart can be reconstructed by the
  reflected beams which carry the info of the heart
  tissue.

Received beams
4
Reconstructed image of heart
Look at the heart from front side
5
Current Limitations

• The system calculates heart function based on
  chamber morphology at the start and the end of a
  contractile cycle.
• Better way measure every step within a
  contractile cycle
• The system measures global heart function.
• Better way measure local cardiomyocyte(????)prope
  rties from small segments of a heart.

6
Benefits to Biology

• Calculating the small segments will
• Discover subtle pathological(??)changes in the
  local tissue of heart (map infarction(??)
  happened in small area)
• Provide us a precise view of the way how the
  heart contracts (defects in different phases of
  the cycle)
• Lead to early-stage diagnosis of heart failure
  (local and subtle changes in heart function
  preceding global failure)

7
Local myocyte properties

• Two crucial parameters Strain and strain rate

Strain rate(???) how fast the length changes.
Strain (??) stretching deformation
Contracted myocyte
faster
Relaxed myocyte
8
How to figure out heart strain

• Step1 Track the movement of the interested
  segments

Pattern ,face of the segment
greenframe2
redframe1
9
How to figure out local strain

• Step2 Record coordinates of these segments in
  whole contraction process
• Step3Use the coordinates to figure out
  displacement within the segments and calculate
  the strain.

10
Example of my speckle-tracking tech

11
Example of segment (white curve along wall)
12
Main Window
13
Detailed result (strain)
14
Detailed result (strain rate)
15
Healthy area
Sick area
An example of a sick heart
16
The meaning of the graphs to biology

sick
Quantitatively distinguishable!
Sick area
Healthy area
Healthy
17
Summary Conclusion

• The previous system have obvious incapacity to
  analyze local heart tissue and the entire
  contraction process.
• The new system quantitatively presents the local
  heart contraction in both amplitude and rate at
  any time point during the cycle and any segment
  of the heart.
• This additional functionality will facilitate
  physiological studies of heart failure in animal
  models.

18
Future work

• Image enhancement from poor quality raw data
• Improve the processing speed by transplanting the
  program to C
• Improve user interface for better and easier
  application

19
Acknowledgement
Thank you for your help and kindness to me!

• My mentors
• Dr. Yibin Wang
• Dr. Aman Mahajan
• Warmhearted organizer
• Dr. Ren Sun
• All my nice lab members
• All my dear friends

yibinxie_at_yahoo.com