Skin: Age related changes in the integument

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SkinAge related changes in the integument
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Age related changes of the skin

• Dec. epidermal proliferation and dermal
  clearance
• Dec. vascularization
• Dec. adherence of epidermal and dermal layers
• Delayed inflammatory response
• Dec. pain perception/ sensory changes
• Dec. Barrier properties
• Inc. vulnerability to aging

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Age related changes in skin affecting wound
healing

• Dec. wound contraction
• Dec. wound breaking strength
• Dec epithelialization
• Attenuated metabolic responses
• Dec. bisynthetic activity of components
• Delayed cellular migration and proliferation
• Dec. rate of wound capillary growth
• Delayed collagen remodeling
• Inc. rate of wound dehiscence

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Local factors affecting wound healing

• Microorganisms
• Foreign bodies/Necrotic tissue/Eschar
• Desiccation
• Pressure, Friction, Shear
• O2- dec. with COPD, CV disease
• Bl supply Surgical technique
• Topical agents

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Systemic factors affecting wound healing

• Age
• Nutrition
• Metabolic disease
• Systemic Meds
• Vascular Insuff
• Immune suppression
• Neurological

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Psychological factors affecting wound healing

• Dementia