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Mouse Breeding Systems

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General Mouse Information. Average lifespan is 2 years. Breeding life ... Don't have to separate mice. Little male burnout. Exact date of birth for each litter ... – PowerPoint PPT presentation

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Title: Mouse Breeding Systems


1
Mouse Breeding Systems
  • General Mouse Information
  • Factors That Influence Breeding
  • Breeding Systems
  • Record Keeping

2
General Mouse Information
  • Average lifespan is 2 years
  • Breeding life is 8 months
  • Reach sexual maturity at 28-42 days of age
  • Breeding onset
  • Females 6-8 weeks Males 8-10 weeks
  • Gestation is 19-21 days
  • Litter size 2-16 pups per litter
  • Breeding retirement
  • After having 5-6 litters or 6-8 months of age

3
Factors That Influence Breeding Production
  • Strain
  • Age
  • Health
  • Technician
  • Temperature
  • Humidity
  • Lighting
  • Diet
  • Water
  • Nesting Material
  • Number of mice
  • Age Bred
  • Disturbances

4
Inbreeding
  • Homozygous animals
  • Inbred strains are desirable due to their high
    degree of homogeneity
  • A strain is considered to be inbred after 20
    consecutive generations of brother/sister matings

5
Line Breeding
  • Homozygous animals
  • More intensive form of inbreeding
  • Animals must have common ancestor in order to be
    bred to each other

6
Outbreeding
  • Heterozygous animals
  • Desirable due to their high degree of individual
    diversity
  • Maintained by random matings. Usually a planned
    breeding scheme that ensures that only unrelated
    animals are bred
  • Usually have bigger litters with stronger, larger
    pups than litters of inbred strains

7
Breeding Systems
  • Monogamous
  • Polygamous
  • Timed
  • Observed

8
MonogamousOne male continuously bred to one
female.
  • Pros
  • Ease of accurate record keeping
  • Uses postpartum estrus
  • Parents are known
  • Dont have to separate mice
  • Little male burnout
  • Exact date of birth for each litter
  • Maximum number of litters per female during her
    life span

9
MonogamousOne male continuously bred to one
female
  • Cons
  • Higher number of males required
  • Higher number of cages
  • If one of the breeders in an inbred strain dies
    it can be difficult, if not impossible to replace
  • If the male is aggressive he may cannibalize pups
    and possibly injure the female

10
Polygamous, AKA Harem BreedingOne male bred to
multiple females
  • Pros
  • Requires fewer males
  • Fewer number of cages needed
  • Can reduce exposure of pups and females to male
    aggression
  • Good way to get large number of litters quickly

11
Polygamous, AKA Harem BreedingOne male bred to
multiple females.
  • Cons
  • Higher level of technician responsibility
  • Fewer litters per female
  • Higher male burnout than monogamous breeding
  • Can be labor intensive
  • Accurate record keeping more difficult
  • May not be sure who the mother is
  • More than one litter can be born in a pan
  • May loose postpartum estrus breeding

12
Trios
  • Often left together
  • Co-parenting
  • Can mix females
  • Can help conception rates
  • Watch for overcrowding
  • Can be hard to determine maternal lineage of pups

13
Timed Matings
  • Mice are bred for a specified period
  • Predictable litter due date
  • Stage of pregnancy
  • Gestational age of pups
  • Does not require checking for plugs
  • Less labor intensive than observed mating

14
Observed Matings
  • Female is bred to male. The next day begin
    checking for vaginal plugs
  • Females are separated from the male once a plug
    is found
  • Predictable litter due date
  • Plug is not a guarantee of pregnancy
  • Requires handling of mice

15
DOCUMENTATION
  • DOB
  • Lineage
  • Identification
  • Strain
  • Sex
  • Dates bred
  • Weaning information
  • Initials
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