DIFFUSE LYMPHATIC TISSUE

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DIFFUSE LYMPHATIC TISSUE
Lymph Nodule
reticular
reticular
fibers
fibers
lymphocytes

Intestinal Mucosa
lamina
propria
(diffuse
cortex
lymphatic
(small lymphocytes)
tissue)
germinal center
(lymphoblasts)
lymphatic nodule
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GUT-ASSOCIATED LYMPHATIC TISSUE (GALT)
lamina
villus
propria
villi
lamina
propria
nodule
Peyers
patch
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TONSILS
diffuse lymphatic
stratified
tissue
squamous
lymphatic
epithelium
nodules
crypts
GC
connective
tissue
capsule
lymphatic nodules
pseudostratified
columnar
with germinal
epithelium
centers
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LYMPHATIC
SYSTEM
LYMPHATIC
VESSELS
LYMPH NODES
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LYMPH NODE
connective tissue
afferent
capsule
lymphatics
subcapsular
sinus
valves
cortical
nodules
trabeculae
medullary
sinus
medullary
cortical
cord
follicle
efferent
germinal
lymphatic
center
blood
hilus
vessels
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LYMPH NODE
HILUS
BV
CORTEX
MEDULLA
NODULES
TRABECULUM
CAPSULE
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LYMPH NODE-CORTEX AND MEDULLA
CAPSULE
CORTEX
MEDULLARY
CORD
MEDULLARY
SINUS
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LYMPH NODE-CORTEX
nodule
capsule
subcapsular
sinus
GC
trabeculum
nodule
trabecular
medullary
sinus
cord
medullary
sinus
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LYMPH NODE CORTEX
TRABECULUM
TRABECULAR
SINUS
RETICULAR
SUBCAPSULAR
FIBERS
SINUS
GC
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THYMUS GLAND
CONNECTIVE
TISSUE
CAPSULE
incomplete
thymic or
lobule
Hassels
medulla
corpuscle
cortex
cortex
cortex
medulla
(no germinal
centers)
medulla
trabeculum
or
septum
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HASSELS CORPUSCLES
Hassels Corpuscle
Hassels Corpuscle
epitheloid cells
(acidophilic)
blood vessel
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CYTORETICULUM
T
CORTEX
LYMPHOCYTES
CORTEX
EPITHELIO-
RETICULAR
MEDULLA
CELLS
HASSELS
CORPUSCLES
MEDULLA
DESMOSOMES
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SPLEEN
trabecular artery
mesothelium
splenic capsule
red pulp
central artery
white pulp
venous sinusoids
closed circulation
penicillar arteries
sheathed arteries
splenic
nodule
(Malphigian
corpuscle)
trabecular vein
open
circulation
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SPLEEN PANORAMIC RED AND WHITE PULP
capsule
capsule
white pulp
red pulp
splenic nodule
nodule
trabeculae
GC
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SPLENIC NODULE, RED AND WHITE PULP
trabeculum
central
artery
nodule
trabecular artery
white pulp
red pulp
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SPLENIC NODULE AND CENTRAL ARTERY
WHITE PULP
NODULE
RED PULP
CENTRAL ARTERY
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TRABECULAR PULP VEINS
TRABECULAE RETICULAR FIBERS
CAPSULE
PULP VEIN
TRABECULUM
RETICULAR
FIBERS
TRABECULAR VEIN
TRABECULUM
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PENICILLUS, SHEATHED ARTERY AND CIRCULATION
sheathed
open circulation
artery
penicillar artery
closed circulation
macrophages
venous sinus
PENICILLUS AND SHEATHED ARTERY
SHEATHED
ARTERY
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Immune Reactions
lymphopoeisis
Bone Marrow
Hemocytoblast
undifferentiated
lymphocyte
Circulation
circulation
Marrow and
Thymus
(immunocompetence)
Nodules
Gland
Circulation
Lymph Nodes
presentation of
presentation of
and Spleen
antibodies
antibodies
memory cell
memory cell
lymphoblast
plasmablast
clonal expansion
clonal expansion
plasma cells
Killers
cell-mediated immunity
antibody
Tissues
antigen
foreign or
phagocytosis
tumor cell
antigen-
antibody
complexes
Destruction of
Antibody
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LYMPHOCYTE ACTIVATION
ANTIGEN BINDING
PATCHING
CAPPING
SECRETION OF IMMUNE
ENDOCYTOSIS
ANTIBODY SYNTHESIS
GLOBULIN (ANTIBODIES)
PLASMA
CELL
CLONAL EXPANSION
(MEMORY CELLS)
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MONOCLONAL ANTIBODY PRODUCTION
myeloma
cells
mouse spleen
mouse immunized to
cells
antigen
fusion induced
with PEG
hybridomas
making several
specific
antibodies
only hybridomas
survive in HAT medium
hybridoma clones
(some making
Immunofluorescence Assay
cell-specific
(test supernatents for cell
specific antibodies)
antibodies)
cultured clone
of hybridomas
making cell-
specific
antibodies