Case Definition

1
Case Definition

• Prepared by
• ABM Alauddin Chowdhury

• CDC

• WHO

2
SARS Pictures

A civet cat Potential SARS host?
3
WHO Case Definition

• Suspected case classified as being disease in a
  person with
• Fever temperature gt380C
• Lower respiratory tract symptoms
• Contact a person who have had SARS?
• History of travel to geographic area

4
WHO Case Definition

• Advise for Clinicians
• Patients should not have their case definition
  category downgraded while still awaiting results
  of laboratory testing or on the basis of negative
  results.
• Use of laboratory methods for SARS diagnosis

5
WHO Case Definition

• Suspect Case
• 1 November 2002 with history of
• High Fever (gt380C)
• AND Cough/Breathing Difficulty
• AND One/more exposures in 10 days
• Close contact
• History of travel
• Residing area

6
WHO Case Definition

• Suspect case (Cont.)
• 2. Unexplained acute respiratory illness
  resulting in death after 1 November 2002
• AND one/more exposures in 10 days
• Close contact
• History of travel
• Residing area

7
WHO Case Definition

• Probable case
• Radiographic evidence of infiltrates consistent
  with pneumonia
• SARS is positive for SARS coronavirus by one or
  more assays.
• Autopsy findings consistent with pathology of RDS
  without identifiable cause

8
WHO Case Definition

• Exclusion Criteria
• A case should be excluded if an alternative
  diagnosis can fully explain their illness
• Reclassification Of Cases

9
Chest X-ray of a SARS Victim
10
Case Definition

• Laboratory Criteria
• Detection of the SARS- CoV antibody by
• indirect fluorescent antibody or enzyme
• linked immunosorbent assay
• Isolation of SARS- CoV in tissue culture
• Detection of SARS- CoV RNA by reverse
• transcriptase-polymerase chain
• reaction, confirmed by a 2nd PCR test