Part 2 Coronaviridae

1
Part 2Coronaviridae

• Coronaviruses are members of a family of large,
  enveloped, positive-sense single-stranded RNA
  viruses, replicate in cytoplasm of animal host
  cells.
• Genomes range in length 27 to 32 kb, the largest
  of any of the RNA viruses
• The virions measure between about 100 and 140 nm
  in diameter.

2
Coronaviridae family three groups

• Group 1 (canine, feline infectious peritonitis,
  porcine transmissible gastroenteritis, porcine
  respiratory viruses, human coronavirus 229E)
• Group 2 (bovine, murine hepatitis, rat
  sialodacryoadenitis viruses, human coronavirus
  OC43)
• Group 3 (avian infectious bronchitis, turkey
  coronavirus)

3
Coronaviruses in animals

• Several coronaviruses cause fatal systemic
  diseases in animals
• Feline infectious peritonitis virus
• Hemagglutinating encephalomyelitis virus
• Infectious bronchitis virus
• Mouse hepatitis virus
• It cause economically important diseases in
  domestic animals.

4
Human coronaviruses

• Human coronaviruses found in both group 1
  (HCoV-229E) and group 2 (HCoV-OC43)
• Major cause of normally mild respiratory
  illnesses
• Known human CoV survives on environmental
  surfaces for up to 3hrs.