Medical Library Association

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Medical Library Association

• Dallas, Texas
• May 21, 2002
• NLM Update
• Donald Lindberg, MD

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NLM Update

• 1. Consumer health information
• 2. Genetic medicine
• 3. NLM grants awards
• 4. New building at NLM
• 5. Terrorism disasters

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Consumer Health Information

• MedlinePlus new features
• Better drug info
• Attention to Low Vision soon
• En Espanol pronto
• ClinicalTrials.Gov
• Adding industry sponsored trials
• Public library efforts

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Genetic Medicine

• NCBI data linkages
• Gene indexing annotation

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NCBI Data Links

• Entrez is NCBIs search retrieval system
• Provides access to sequence, mapping, taxonomy,
  and structure data
• Graphic views of sequences chromosome maps
  references
• BLAST - sequence similarity searching
• 15 seconds for search vs 15 M sequences and gt14B
  base pairs from gt100K species
• Accessed via Web gt200K/day by gt50K researchers

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Old stuff.Wheres the new stuff?
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NCBI protein db survey
1,913 Respondants

• Protein function based on experimental evidence
  from published literature
• Classification into protein families based on
  sequence similarity and function
• Identification of protein domain architecture,
  with links to alignments and structure
• Annotation of functional sites, processing
  pathways, and degradation sites based on evidence
  from published literature
• Features derived from computational predictions

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Gene Indexing an article from Nature
Neuroscience

• Indexers create link between article PMID and
  mouse Myo7a gene record in LocusLink
• Indexers add descriptive statement to mouse Myo7a
  gene record in LocusLink participates in
  anchoring and holding membrane-bound elements to
  the actin core of the stereocilium

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NLM Indexing Project

• PubMed articles attached to gene products as part
  of the MeSH indexing flow
• 300 articles -gt 37 links 1 link per 8 articles
• 5,524 articles -gt 417 links 1 link per 13
  articles
• 535,000 articles a year gt 27,000 to 53,000 links
  between protein and literature per year

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NLM Grants Awards

• Protein data base - Request for Proposal
• BISTI Program
• NLM Training Grants
• IAIMS
• NN/LM new contracts
• Scalable Information Systems

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RFP for new central Data Base of Protein Sequence
Function

• NLM, NHGRI, NIGMS, NIMH, NCRR, NIDCR
• Repository of curated protein sequences
• Annotated re both sequence and function
• Coordinate entries reference terminology with
  data bases containing complementary data,
  including those of NCBI
• Applications due April 2002 award August 2002
• USA and foreign
• Cooperative agreement
• Scientific Advisory Panel of national experts

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BISTI Biomedical Information Technology
Initiative

• Columbia Univ - NLM - 700M
• Yale Univ - NLM - 400M
• Univ Utah - NHLBI - 700M
• Institute for Systems Biology - NIGMS - 700
• Rutgers Univ - NIGMS - 400M
• Stanford Univ - NIGMS - 400M

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Columbia University BISTI

• Center for Computational Biology Bioinformatics
• Program of education research
• Single Nucleotide Polymorphism analysis
  relationship to human disease
• Protein structure analysis
• Tile analysis of microarrays
• Functional annotation of proteins
• Study of networks of interacting proteins
• 3D structure-based design of new pharmaceuticals

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Yale University BISTI

• Biomedical Computing Center of Excellence
• Program
• Heterogeneous biomedical data base design
• e.g. for microarray experimental results
• Data mining to relate protein characteristics to
  gene expression

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List of Training Grant Sites
UNIVERSITY OF CALIFORNIA LOS ANGELES CA UNIVERSIT
Y OF WISCONSIN MADISON WI MEDICAL UNIVERSITY OF
SOUTH CAROLINA SC UNIVERSITY OF
WASHINGTON WA UNIVERSITY OF CALIFORNIA
IRVINE CA VANDERBILT UNIVERSITY TN JOHNS
HOPKINS UNIVERSITY MD STANFORD
UNIVERSITY CA UNIVERSITY OF MINNESOTA TWIN
CITIES MN YALE UNIVERSITY CT UNIVERSITY OF
PITTSBURGH AT PITTSBURGH PA COLUMBIA UNIVERSITY
HEALTH SCIENCES NY OREGON HEALTH SCIENCE
UNIVERSITY OR UNIVERSITY OF MISSOURI
COLUMBIA MO HARVARD UNIVERSITY (SCH OF PUBLIC
HLTH) MA RICE UNIVERSITY TX INDIANA
UNIV-PURDUE UNIV AT INDIANAPOLIS IN UNIVERSITY
OF UTAH UT
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NLM IAIMS Grants

• PLANNING 2 years - 150,000 per year
• OPERATIONS 4 years - 400,000 per year, directs
  only prerequisite written plan or testing
  evaluation report
• PILOT STUDY - 2 years 75,000 per year
• TESTING EVALUATION 2 years - 100,000 per
  year
• IAIMS FELLOWSHIP 1 or 2 years - 50,000 per year
  plus 6,000 administrative supplement

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NLM IAIMS Grants

• Program priorities
• Reach beyond a single organization
• Deliver direct information services to users,
  especially consumers
• Benefits underserved rural or inner-city
  populations
• Involve the library, informatics and other
  information groups

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Application of Advanced Network Infrastructure
Technology in Health and Disaster Management

• focus on situations that will require or greatly
  benefit from these technologies in health care,
  medical decision-making, public health,
  large-scale health emergencies, health education,
  and biomedical, clinical and health services
  research
• must involve the use of testbed networks linking
  hospitals, clinics, health-related schools,
  libraries, research centers and laboratories,
  and/or public health authorities

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Application of Advanced Network Infrastructure
Technology in Health and Disaster Management

• demonstrate one or more of the following
  capabilities
• 1) Self-scaling applications
• 2) Self-optimizing, end-to-end network aware,
  real-time applications and/or middleware
• 3) Wireless applications
• 4) Nomadic application and/or applications using
  geographic information systems (GIS) techniques
• 5) Applications which involve advanced
  identification methodologies, e.g., biometrics or
  smartcards.
• NLM URL http//www.nlm.nih.gov/oam/oam.html

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Third NLM Building

• Need
• Design
• Future of medical libraries

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Alison Bunting
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Need for an additional NLM Building

• 1100 people in a space designed for 600
• Four temporary remote locations
• No more space to store additions to the library
  collections after 2004
• Architectural updating needed
• Americans with Disability Act
• Normal deterioration in some sections
• New security demands

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Crowded Library Conditions 1
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Crowded Library Conditions 2
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Design So Far
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Medicines Library of the 21st Century
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Research Building (38B) 200,000 gsf
Visitor Conference Center 40,000 gsf
Lister Hill Center (38A)
110,000 gsf growth Existing library (38)
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Collaboratory
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Terrorism Disasters

• NLM is not an intelligence agency
• NLM supported research includes
• Info systems to detect epidemics
• Info systems for use in emergencies
• Info systems to support early warning emerging
  bio-threats
• NIH/NLM are getting more security conscious
• Disaster management
• NLMs security efforts
• NLM / PAHO partnership in central America

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Bio-metrics - iris scan
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Bio-metrics - hand geometry
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NLM / PAHO in Honduras
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Cecilia Garcia
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Hurricane Mitch
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End
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Cecilia Garcia
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