JOJOBA

1
JOJOBA

• Oral Gel

2
JOJOBA

• History
• 1977-1980 Jojoba plant extract was used
  effectively as cosmetic material.
• 1982-1985 Jojoba was considered to be non
  irritant promoter to skin when applied to intact
  and abraded skin.
• 1982-1985 Jojoba proved not to interfere
  biological processed its purity
  indigestibility.
• 1987-1997 Jojoba oil proved to have marked
  anti-inflammatory anti-bacterial action.
• 1997-1999 Studies were to seek the further
  information about the value of Jojoba oil in the
  management of Recurrent Aphthous Ulceration (RAU).

3
JOJOBA

• The Bacterial Action
• The immune system seems actively involved in
  reaction to bacterial and auto-immune antigens.
• It might be speculated that form Streptococci
  infect epithelium of the salivary gland ,
  stimulate formation of antibodies fix complement
  and cause cytolysis.
• The disease may be further complicated by an
  auto-immune reaction to released antigens (L)
  from epithelium tissues.
• Alternatively an auto-immune reaction to oral
  epithelium might serve as predisposing factor to
  fertilize the soil for an L-Streptococcal
  infection resultant necrosis and ulcer
  formation.

4
JOJOBA

• Antimicrobial Effect
• Zanial et Al 1994 reported an antimicrobial
  action of jojoba oil.
• This action play a role in controlling RAU which
  might have a relation to cell mediated immunity
  against Streptococcus 2A oral mucous which is
  significantly increased in relation to
  exacerbation of RAU.

5
JOJOBA

• Antimicrobial Effect
• The molecular structure of Jojoba oil showed that
  it is a fat acid ester of decylalcohol and
  discosanol alcohols. Due to the Jojoba structure
  properties it is used for skin care especially
  -Skin dehydration.-Skin inflammation.-Controll
  ing Psoriasis Acne.-Transdermal patches for
  drug.-Base for topical ointment.
• It decreases its hydrolysis in the GIT since
  large amount unhydrolyzed oil were excreted.
• Thus, Jojoba oil has been suggested to be used as
  a dietic oil since it will not be metabolized by
  the human body the fat-splitting enzymes
  lipase is found to be unable to hydrolyzes the
  oil.

6
JOJOBA

• Nutritional properties
• The nutritional properties of Jojoba were
  examined in 4 weeks feeding study rat fed a diet
  with Jojoba-Hematology showed a dose related
  increase in white blood cells.
• Arnouts Al s clinical chemistry revealed
  significant increased levels of various
  enzymes-Reported an increase in growth hormone
  Thyrotoxin Insulin like growth factor in
  Jojoba fed animal.

7
JOJOBA

• Toxicity
• Acute toxicity of massive of crude Jojoba oil in
  mice was minimal.
• Jojoba reduce insignificant irritations in the
  eyes of animals.
• Rude refined Jojoba oils can be considered safe
  for the human skin except for patients with skin
  disorders who are inherently hyper-allergic to
  cosmetic base oils.

8
JOJOBA

• Effect of Jojoba Lignocaine treatment in from
  patient opinion.

9
JOJOBA

• Effect of Jojoba Lignocaine treatment in from
  dentist opinion.

10
JOJOBA

• Although the specific nature of Aphthous
  stomatitis is unknown, most evidence suggests
  that it is a non infectious inflammatory mucosal
  disease.
• The response of the disease to topical Jojoba
  supports this assumption and suggests that the
  mechanism by which Jojoba improved recurrent
  Aphthous ulceration (RAU) is through the
  reduction in local inflammatory cell activity.