Affective Disorders

1
Affective Disorders

• Disorders and Mechanisms
• Major Depression
• Bipolar Disorder
• Therapies
• MAOIs
• TCAs
• 2nd generation (SSRIs)
• Lithium

2
Affective Disorders

• Major Depression
• Symptoms
• Anhedonia
• Course
• Bipolar Disorder
• Symptoms
• Mania
• Course

3
Neurochemistry of Depression

• Monoamine hypothesis
• Dopamine, NE, 5-HT
• Reserpine

4
Neurochemistry of Depression

• Serotonin dysfunction
• Measurement of 5-HT
• Turnover (5-HIAA)
• Tryptophan concentration
• Receptor-binding
• Challenge
• Imaging

5
Therapies - MAOIs

• MAOIs
• Mechanism
• Side effects/cautions

6
Therapies - TCAs

• TCAs
• Mechanism
• Side Effects

7
Therapies - SSRIs

• SSRIs
• Mechanism
• Side effects
• Dependence?

8
Therapies - Others

• Third generation antidepressants
• ECT
• Mechanism
• Side effects
• TMS
• Mechanism
• Side effects
• TMS Movie

9
Therapies Bipolar Disorder

• Lithium
• Mechanism
• Side effects
• Others
• Carbamazepine (Tegretol)
• Valproate (Depakene)
• Topiramate (Topamax)
• Tiagabine (Gabitril)

10
Neurochemistry of Depression

• Antidepressant effects
• Serotonin
• Postsynaptic receptors
• Autoreceptors
• Norepinephrine
• MHPG levels
• Interaction

11
Animal Models of Depression

• Reserpine-induced sedation
• Behavioral despair
• Forced swim test
• Learned helplessness
• Maternal separation