Neuro Drugs by class

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Neuro Drugs (by class)
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Short Acting Alprazolam, Oxazepam Med Acting
Clonazepam, Lorazepam
Benzodiazepines
Not addictive
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Anti-psychotics (1 of 3)
Neuroleptic Malignant Syndrome Life-threatening
condition, extreme muscle rigidity, hyperthermia,
CV instability, and altered level of
consciousness (likely due to enhanced sensitivity
of DA receptors due to DA blockers) ? Treat w/
bromocriptine (DA agonist) and dantrolene (the
same thing you use for malignant hyperthermia)
Kaplan pharm pg 165
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Anti-psychotics (2 of 3)
From Kaplan (all other Kaplan info is green text)
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Anti-psychotics (3 of 3) Side Effects
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If one dose doesnt fix, take 2nd 2 hrs later

• Migraine Prophylaxis
• Propranolol (hard for pts to exercise)
• Valproic Acid (hairy, bad teeth, etc.)
• Methysergide (see above)
• Topiramate (kidney stones, inhibit oral
  contraceptives)
• All work by increasing the threshold of central
  neurons ? decreasing the firing in the trigeminal
  complex (nucleus caudalis)
• Alternatives B2 (dark urine), Mg

• Triptan Contraindications
• Cardiovascular Disease
• Basilar Migraines
• Pregnancy
• Related to intense vasoconstrictor action

Note (per Dr. Pruitt) lots of people have
migraines that dont meet these criteria (up to
94 of HA that present are migraines)but beware
3 are brain tumors (etc.)
5HT-1B present on BVs CN V 5HT-1D present
on coronary gt cerebral BVs
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Anti-depressants (also Anxiolyticsnot all pts on
these are depressed)
Note 5HT-1A is the inhibitory autorecptor ?
works against the SSRIs b/c you increase 5HT
and then it hits 5HT1A decreasing the rate of
firing
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Anxiety treat w/ antidepressants (except SNRIs,
Trazodone)
Drugs by Rausch (not covered elsewhere) note
anything in blue is from Rausch

• Bipolar Disorder ? Mood Stabilizers
• Lithium
• Anti-convulsants
• Anti-Psychotics
• Do not use antidepressants b/c inc rate of
  cycling

Notes on Depression Treatment
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CNS Stimulants (note pink text wont be on our
test, I looked it up)
First Aid, 2004 ed (pg 326)

• Withdrawal from cocaine, amphetamine
• Anxiety
• Guilt
• Insomnia
• Depression
• Anhedonia

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