Essential Glyconutrient: GLUCOSE

1
Essential Glyconutrient GLUCOSE
2
HAVE YOU HEARD OF GLYCONUTRIENT THERAPY ?
Dr. Hudson, I pray you will have the time to
answer a few questions for me. My daughter has
cervical cancer that has metastasized into her
colon and lungs. My sister-in-law, who has no
medical training, insists that she will die
unless we give her high doses of a nutritional
supplement marketed by Mannatech called
Ambrotose. According to her, this is the ONLY
way she will get the necessary glyconutrients
necessary to help her body rid her self of the
cancer. She is laying the guilt on heavily as her
oncologist has recommended against taking any
nutritional supplements. I am contacting you
as she has referenced you as a source of
information on glyconutrients. Do you have any
opinion on nutritional supplements such as
Ambrotose and their effectiveness or lack of?
http//online.barrons.com/article_print/SB11154229
0501327322.html
3
(No Transcript)
4
SOME PATIENTS HAVE HEPATIC FIBROSIS AND
PROTEIN- LOSING ENTEROPATHY
5
BEFORE MANNOSE
DURING MANNOSE
AT III
albumin (g/dl)
anticoagulation (Marcumar R )
i. v. albumin substitution
fecal alpha1 AT (mg/g)
time in months
6
The Simple Life--Glucose, Mannose, Glycoproteins
Man
Glc
PMI
Fru-6-P
Man-6-P
PMM
Man-1-P
Glycolysis
Glycoprotein
7
FUCOSE THERAPY NORMALIZES NEUTROPHIL COUNTS OF
ONE CDG-IIc PATIENT
Serum Fucose (µM)
Normal Range
8
(No Transcript)
9
(No Transcript)
10
(No Transcript)
11
(No Transcript)
12
(No Transcript)
13
(No Transcript)
14
THINK ABOUT

• A. POINTS OF CONTROL AND POTENTIAL REGULATION
• B. WHY THERE ARE MULTIPLE WAYS OF GENERATING THE
  SAME PRECURSOR

QUESTIONS 1.     What is meant by essential
monosaccharides? 2.     Mammalian plasma
contains glucose (5 mM) and mannose, which is
present at 50-100uM, but no other
monosaccharides. Where does mannose come from?
How is it metabolized? 3.     Some cells have
extremely low activity of enzymes needed to
generate activated monosaccharides. The
inactivation of genes encoding these enzymes in a
mouse is lethal, so how do deficient cells
survive without the biosynthetic enzymes? 4.    
How are nucleotide sugar transporters 
distributed in the Golgi? Does this distribution
influence glycosylation? What are the advantages
of transporters that transfer multiple substrates?