Experiment 6:

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Experiment 6

• EXTRACTION of ANALGESICS

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Objectives

• To learn the technique of acid-base extraction.
• To separate aspirin from acetaminophen using the
  extraction technique.
• To learn the techniques of drying organic
  solvents and vacuum filtration.
• To analyze the purity of the aspirin and
  acetaminophen samples using HPLC analysis.

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ANALGESICS IN GOODYS POWDERS
500 mg/powder 325
mg/powder
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SEPARATORY FUNNEL TECHNIQUE
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ACIDBASE EXTRACTION OF ASPIRIN AND ACETAMINOPHEN
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ACIDBASE EXTRACTION OF ASPIRIN AND ACETAMINOPHEN
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THEORETICAL RECOVERY

• For this experiment, we dissolved 2 Goodys
  powders in 25mL of ethyl acetate.
• In each Goodys powder, there is 0.500g of
  aspirin and 0.325g of acetaminophen.
• Theo. Recovery
• 0.500g per powder X 2 powders ?g of Aspirin
• 0.325g per powder X 2 powders ?g of
  Acetaminophen

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SAFETY CONCERNS

• Acetone and ethyl acetate are extremely
  flammable! Wear safety goggles at all times and
  use extreme caution when heating!

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WASTE MANAGEMENT

• The drying agent (MgSO4) and filter paper should
  be placed in the container labeled MgSO4 Waste
  provided in the hood.
• The aqueous acidic phase left after filtering off
  aspirin should be placed in a bottle in the hood
  labeled "Acidic Waste (Aspirin).