PRIME 2006 Angelina Altshuler

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PRIME 2006Angelina Altshuler

• Monash University
• Melbourne, Australia
• July 14, 2006

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Project Plan

• The UCSD MATLAB version of the LabHEART model
  (Puglisi and Bers, Am J Physiol, 2001), which
  calculates ionic currents, Ca-transients, and
  action potentials in epicardial, mid-myocardial,
  and endocardial rabbit ventricular myocytes has
  been found unstable at high frequencies over long
  periods of time
• Use Nimrod/G to sweep over a range of frequencies
  to identify instabilities in calcium transients
  and action potential calculations
• Apply Nimrod/O to optimize the stability in the
  maximum values of the calcium transient and
  action potential data calculated from the
  LabHEART model by sweeping through a range for
  each parameter

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Cardiac Modeling Using LabHEART

• Progress To Date
• Linked the LabHEART model to Nimrod/G system and
  adjusted the LabHEART MATLAB code
• Ran 1 minute Nimrod/G experiments at 1-10 hertz
  frequency in epicardial, mid-myocardial, and
  endocardial rabbit ventricular myocytes
• Graphed calcium transient and action potential
  and verified model stability for frequencies
  between 1-4 hertz
• Identified instabilities in the model at
  frequencies greater than 5 hertz in calcium
  transients and action potential calculations,
  mainly in the mid myocardial cells

• Future Goals
• Continue running Nimrod/G experiments with the
  LabHEART model
• Develop an efficient method connecting Nimrod/0
  to the LabHEART MATLAB model to optimize the
  stability in the maximum values of the calcium
  transients and action potential graphs
• Program in MATLAB the necessary adjustments to
  use Nimrod/O
• Starting at 5 hertz, determine the constants that
  best stabilize the calcium transient and action
  potential calculations in the model

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Action Potential and Calcium Transient Graphs
Produced from the LABHEART Model
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Adventures in Australia